Increased mortality in patients with standard EEG findings of ‘diffuse slowing’

Wanzek, Robert; Bormann, Nicholas L.; Shabbir, Yaseen; Saito, Taku; Yamada, Thoru; Shinozaki, Gen

doi:10.12788/acp.0018

Cited by 3 publications

(3 citation statements)

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“… 32 , 33 The present finding suggests that BSEEG may be useful for predicting both a short-term and a long-term mortality in elderly inpatients. This result is consistent with the recent prospective cohort study 10 and retrospective cohort study 11 showing that clinical electroencephalography slowing is associated with an increased mortality. Furthermore, short-term mortalities and relative risks in BSEEG-positive patients were higher in patients with dementia compared to those without dementia.…”

Section: Discussionsupporting

confidence: 93%

“… 9 In fact, we showed that BSEEG score can predict mortality of elderly inpatients better than clinical categorization of delirium. 9 Consistent with our previous findings of higher BSEEG score indicative of slow brain wave and its association with increased mortality, a recent prospective cohort study 10 and a retrospective cohort study 11 showed that clinical electroencephalography slowing is associated with higher mortality. However, there is neither a replication study for the utility of BSEEG nor an investigation of the utility of BSEEG for subjects with dementia.…”

Section: Introductionsupporting

confidence: 84%

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Mortality prediction by bispectral electroencephalography among 502 patients: its role in dementia

Saito

Malicoat

Leyden

et al. 2021

Brain Communications

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Complications of delirium and dementia increase mortality; however, it is difficult to diagnose delirium accurately, especially among dementia patients. The bispectral electroencephalography (BSEEG) score can detect delirium and predict mortality in elderly patients. We aimed to develop an efficient and reliable BSEEG device for high-throughput screening. We also hypothesized that BSEEG score can predict mortality among dementia patients. A prospective cohort study was conducted between January 2016 to December 2018 to measure BSEEG from elderly patients and correlate with outcomes. A total of 502 elderly (55 years old or older) patients with and without dementia were enrolled. For a replication of the utility of BSEEG, mortalities between BSEEG-positive and BSEEG-negative group were compared. In addition, patients with and without dementia status was added to examine the utility of BSEEG among dementia patients. The mortality within 180 days in the BSEEG-positive group was higher than that of the BSEEG-negative group in both the replication and the total cohorts. Mortality of those in the BSEEG-positive group showed a dose-dependent increase in both cohorts. When the dementia patients showed BSEEG positive, their mortality was significantly higher than those with dementia but who were BSEEG-negative. Mortality within 30 days in the BSEEG-positive group was significantly higher than that of the BSEEG-negative group. The utility of the BSEEG to predict mortality among large sample of 502 elderly patients was shown. The BSEEG score can predict mortality among elderly patients in general, and even among dementia patients, as soon as 30 days.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionsupporting

confidence: 84%

Mortality prediction by bispectral electroencephalography among 502 patients: its role in dementia

Saito

Malicoat

Leyden

et al. 2021

Brain Communications

Self Cite

View full text Add to dashboard Cite

show abstract

“…Тип V означает, что у пациентов на первый план выступают уже не регуляторные, а структурные поражения в коре головного мозга. При наличии ЭЭГ данного типа есть все основания говорить о грубых (тяжелых) органических поражениях мозга [12,18]. В группе пациентов без ЭОПГМ такие изменения на ЭЭГ отсутствовали.…”

Section: таблица 2 частотный анализ встречаемости типов ээг (по еа жи...unclassified

Features of the Background EEG of Alcohol Dependent Patients with Comorbid Exogenous Organic Brain Damage

Galkin,

Kisel,

Bokhan

2024

Psychiatry

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Background: the range and prevalence of complicating pathologies in alcoholism indicate the need for a thorough examination of patients using modern diagnostic approaches. The aim was to study the indicators of spontaneous electrical activity of the brain in patients with alcohol dependence with comorbid exogenous organic brain damage non-alcoholic nature. Patients and methods: a study of electroencephalograms of 148 men with alcohol dependence using the classification of E.A. Zhirmunskaya (1984) was conducted. Results: based on the hystory data, 85 (57.4%) patients were found to have exogenous organic vascular brain damage (including hypertension in 57 (38.5%) cases, chronic cerebral circulation disorder — in 8 (5.4%), somatoform autonomic dysfunction — in 7 (4.7%)) and traumatic character (mild traumatic brain injury) in 13 (8.8%)) patients. The analysis using Fisher’s exact criterion revealed statistically significant differences between patients with alcohol dependence and alcoholism patients with comorbid exogenous organic brain damage in the frequency of occurrence of various types of electroencephalograms (p < 0.001). The study clearly showed that the presence of exogenous organic brain damage in patients with alcoholism leads to more pronounced functional changes in the brain. Conclusion: early detection of pathological activity on the EEG in patients with alcohol dependence will allow clinicians to carry out appropriate therapeutic and diagnostic measures in a timely manner and will provide additional information necessary for the development of personalized medical rehabilitation programs for patients taking into account their neurophysiological profile.

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Electroencephalography as a tool for assessing delirium in hospitalized patients: A single-center tertiary hospital experience

Mohamad Faizal,

Tan,

Tan

et al. 2024

J Cent Nerv Syst Dis

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Background Delirium is a prevalent yet underdiagnosed disorder characterized by acute cognitive impairment. Various screening tools are available, including the Confusion Assessment Method (CAM) and 4 A’s test (4AT). However, the results of these assessments may vary among raters. Therefore, we investigated the objective use of electroencephalography (EEG) in delirium and its clinical associations and predictive value. Method This cross-sectional observational study was conducted at Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan, Malaysia, from April 2021 to April 2023. This study included patients aged ≥18 years with a preliminary diagnosis of delirium. Demographic and clinical data were collected along with EEG recordings evaluated by certified neurologists to classify abnormalities and compare the associated factors between patients with delirium with or without EEG abnormalities. Results One hundred and twenty patients were recruited, with 80.0% displaying EEG abnormalities, mostly generalized slowing (moderate to severe) and primarily generalized slowing (mild to severe), and were characterized by theta activity. Age was significantly associated with EEG abnormalities, with patients aged 75 and older demonstrating the highest incidence (88.2%). The CAM scores were strongly correlated with EEG abnormalities (r = 0.639, P < 0.001) and was a predictor of EEG abnormalities ( P < 0.012), indicating that EEG can complement clinical assessments for delirium. The Richmond Agitation and Sedation Scale (RASS) scores (r = −0.452, P < 0.001) and Barthel index (BI) (r = −0.582, P < 0.001) were negatively correlated with EEG abnormalities. Additionally, a longer hospitalization duration was associated with EEG abnormalities (r = 0.250, P = 0.006) and emerged as a predictor of such changes ( P = 0.030). Conclusion EEG abnormalities are prevalent in patients with delirium, particularly in elderly patients. CAM scores and the duration of hospitalization are valuable predictors of EEG abnormalities. EEG can be an objective tool for enhancing delirium diagnosis and prognosis, thereby facilitating timely interventions.

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Increased mortality in patients with standard EEG findings of ‘diffuse slowing’

Abstract: doi: medRxiv preprint NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.

Cited by 3 publications

References 28 publications

Mortality prediction by bispectral electroencephalography among 502 patients: its role in dementia

Mortality prediction by bispectral electroencephalography among 502 patients: its role in dementia

Features of the Background EEG of Alcohol Dependent Patients with Comorbid Exogenous Organic Brain Damage

Electroencephalography as a tool for assessing delirium in hospitalized patients: A single-center tertiary hospital experience

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