Increased muscular triglyceride content and hyperglycemia in Goto-Kakizaki rat are decreased by egg white hydrolysate

Abstract

We investigated the fat metabolic characteristics in non-obese and diabetic Goto-Kakizaki (GK) rat and the effects of dietary egg white hydrolysate (EWH) on glucose and fat metabolism. Wistar (W) and GK (G) rats were placed into dietary casein (WC and GC) or EWH (WE and GE) group, and fed their respective diet for six weeks. Triglyceride (TG) content and stearoyl-CoA desaturase (SCD) indices in the soleus muscle were higher in the GC group than WC group in parallel with worsening serum glucose metabolic parameters. The glucose metabolic parameters were significantly improved in the GE group. The TG accumulation and SCD indices in the soleus muscle were also significantly lower in the GE group than in the GC group. In conclusion, dietary EWH not only improved glucose metabolism but also reduced both TG accumulation and SCD indices in the soleus muscle of GK rat.

Egg White Hydrolysate Can Be a Low-Allergenic Food Material to Suppress Ectopic Fat Accumulation in Rats Fed an Equicaloric Diet

“…However, few reports have investigated the nutritional effects of EWH. In our previous study, dietary EWH decreased triacylglycerol (TAG) accumulation in muscles and liver in spontaneous diabetic Goto-Kakizaki rats (4). We also showed suppressive effects of EW and EWH on fat accumulation not only in the liver and muscles but also in intra-abdominal adipose tissues and carcasses of normal rats fed a high-fat and high-sucrose diet (HFSD) ad libitum (5).…”

Egg White Hydrolysate Improves Glucose Tolerance in Type-2 Diabetic NSY Mice

“…We have also reported that EWH improves fasting serum glucose and insulin levels in diabetic Goto-Kakizaki (GK) rats (1) and Wistar rats (2). These findings suggest that in addition to improving fat metabolism, EWH can prevent the onset of glucose intolerance and T2DM.…”

“…Fecal excretion of TG and CHO was numerically higher in the NE and NEH groups than that in the NH groups although the fecal weights and fecal total lipids content were equal (Table 2). From the results of lipids analyses, EW clearly suppressed CHO accumulation, which is supposed to be caused by lower lipid absorption and fat synthesis (1)(2)(3)26). EWH slightly suppressed the CHO accumulation, but the effect was weakened compared to EW.…”

“…However, the plasma total GLP-1 level in both fasting and non-fasting states and the fasting plasma adiponectin level were not unexpectedly changed by the EW and EWH diets ( Table 2). In our previous study (1), the plasma activity of dipeptidylpeptidase-4, an enzyme to inactivate GLP-1, was not changed by EWH in GK rats. These results indicate that the suppression of glucose levels in the NEH group during OGTT and ipGTT was not caused by glucose-mediated secretion of incretin and insulin and adiponectin pathways, but caused by both small intestine-dependent and -independent mechanisms.…”

“…EW has been reported to suppress food intake, dietary fat absorption, and fat accumulation in rats in our previous studies (1)(2)(3); therefore, EW can be considered for the prevention and treatment of obesity and type 2 diabetes mellitus (T2DM) in humans. However, egg-specific proteins in EW are well known to be major allergens in humans.…”