Increased N200 and P300 latencies in cognitively impaired elderly carrying <i>ApoE</i> ε‐4 allele

Cintra, Marco Túlio Gualberto; Ávila, Rafaela; Soares, Thayana Oliveira; Cunha, Lorena Araújo da; Silveira, Kátia D.; Moraes, Edgar Nunes de; Simas, Kaique; Fernandes, Renato Bragança; Gonçalves, Denise Utsch; Rezende, Nilton Alves de; Bicalho, Maria Aparecida Camargos

doi:10.1002/gps.4773

Cited by 18 publications

(24 citation statements)

References 46 publications

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“…The majority of the 25 studies that analyzed P300 amplitude reported smaller amplitude in AD compared to HC groups [i.e., 60%; 3,4,13,42- 43,60,63,71,84,89,114,118,142,145,152], including one reporting a trend that did not reach statistical significance[42]. The remaining ten studies reported no significant difference between groups [i.e., 40%;31,47,69,[72][73]92,105,110,126,139]. These latter AD studies were notable for small sample sizes (e.g., eight per cell), age differences between groups, high AD group MMSE scores (e.g., 27/30), and/or simple tasks (i.e., 67% oddball paradigms), which may have limited power to detect group differences.…”

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confidence: 99%

“…The majority reported delayed latency in AD compared to HC groups [i.e., 66%; 3,43,52,60,63,71,76,88,92,96- 97,105,110-111,118,135,139,142,145,152], two of which reported non-significant trends[52,145]. No significant differences between groups were detected in eight studies [i.e., 27%; 4,31,47,69,75,84,114,126]. Two studies in fact reported shorter P300 latency in AD compared to HC groups [i.e., 7%; 13,72], although interpreting this in context of other studies is difficult because one also reported high P300 variability in the AD group[13], and the other used an Three of five APOE studies reported delayed P300 latencies in the ɛ4+ group when using an olfactory identification task [i.e., 60% of total studies;93,95,147].…”

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confidence: 99%

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A systematic review of cognitive event-related potentials in mild cognitive impairment and Alzheimer’s disease

Paitel

Samii

Nielson

2021

Behavioural Brain Research

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This systematic review examined whether event-related potentials (ERPs) during higher cognitive processing can detect subtle, early signs of neurodegenerative disease. Original, empirical studies retrieved from PsycINFO and PubMed were reviewed if they analyzed patterns in cognitive ERPs (³150ms post-stimulus) differentiating mild cognitive impairment (MCI), Alzheimer's disease (AD), or cognitively intact elders who carry AD risk through the Apolipoprotein-E ε4 allele (ε4+) from healthy older adult controls (HC). The 100 studies meeting inclusion criteria (MCI=47; AD=47; ε4+=6) analyzed N200, P300, N400, and occasionally, later components. While there was variability across studies, patterns of reduced amplitude and delayed latency were apparent in pathological aging, consistent with AD-related brain atrophy and cognitive impairment. These effects were particularly evident in advanced disease progression (i.e., AD > MCI) and in later ERP components measured during complex tasks. Although ERP studies in intact ε4+ elders are thus far scarce, a similar pattern of delayed latency was notable, along with a contrasting pattern of increased amplitude, consistent with compensatory neural activation. This limited work suggests ERPs might be able to index early neural changes indicative of future cognitive decline in otherwise healthy elders. As ERPs are also accessible and affordable relative to other neuroimaging methods, their addition to cognitive assessment might substantively enhance early identification and characterization of neural dysfunction, allowing opportunity for earlier differential diagnosis and targeting of intervention. To evaluate this possibility there is urgent need for well-powered studies assessing late cognitive ERPs during complex tasks, particularly in healthy elders at risk for cognitive decline.

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confidence: 99%

A systematic review of cognitive event-related potentials in mild cognitive impairment and Alzheimer’s disease

Paitel

Samii

Nielson

2021

Behavioural Brain Research

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“…All 14 articles included were cross-sectional investigations. 14-27 Studies were conducted in 5 different countries: the United States (n = 7 studies), 16-18,20,21,23,27 Norway (n = 3 studies), 19,24,25 China (n = 2 studies), 15,26 Brazil (n = 1 study), 14 and Taiwan (n = 1 study). 22…”

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confidence: 99%

A Systematic Review of Altered P300 Event-Related Potential in Apolipoprotein E4 (APOE4) Carriers

et al. 2020

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Background Apolipoprotein ε4 allele ( APOE4) is the strongest genetic risk factor for Alzheimer’s disease and seems to be related to cognitive decline and damaged event-related potential P300, which is a sensitive measure to assess cognitive processing. Objective This research aims to critically review the existing scientific evidence regarding the association between APOE4 and P300. Methods A systematic review was carried out up to January 2020 on the following databases: Web of Science, Scopus and Medline/PubMed. Articles were considered for inclusion if they are original research that provided information regarding the association between APOE4 and P300, available in English, Spanish, or Portuguese, and available in full text. The methodological quality of the studies selected was evaluated using the quality assessment tool for observational cohort and cross-sectional studies recommended by Cochrane. Results Out of 993 studies, 14 met the inclusion criteria. The results obtained showed that APOE4 is related to a longer P300 latency. However, the data supplied do not allow us to confirm if this relationship also occurs in amplitude measures. Moreover, it was observed that APOE genotype may influence P300 in different ages, from younger individuals to demented older people. Conclusion Evidence shows that APOE4 negatively influences cortical activities related to cognitive functions, as indicated by P300.

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“…The P300 is very clearly correlated with cerebral aging and provides a distinction between neurodegenerative diseases such as Alzheimer's disease and thymic disorders [20][21][22].…”

Section: Cardiovascular Evaluation and Other Measuresmentioning

confidence: 99%

Results of a preliminary study on the effects of a compound on telomeres length, biological and physiological parameters

Jaeger¹,

Lamberti²,

Leeuwen³

et al. 2021

J Biol Med

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Increased N200 and P300 latencies in cognitively impaired elderly carrying ApoE ε‐4 allele

Abstract: Latencies of N200 and P300 increased in cognitively impaired patients with the presence of ApoE ε-4 allele.

Cited by 18 publications

References 46 publications

A systematic review of cognitive event-related potentials in mild cognitive impairment and Alzheimer’s disease

A systematic review of cognitive event-related potentials in mild cognitive impairment and Alzheimer’s disease

A Systematic Review of Altered P300 Event-Related Potential in Apolipoprotein E4 (APOE4) Carriers

Results of a preliminary study on the effects of a compound on telomeres length, biological and physiological parameters

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