Increased Nitric Oxide Production in the Spermatic Vein of Patients with Varicocele

Özbek, Emin; Türköz, Yusuf; Gökdeniz, Remzi; Davarci, Mürsel; Özuğurlu, Fikret

doi:10.1159/000020135

Cited by 98 publications

(71 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…54 Increased NO has also been demonstrated in the spermatic veins of patients with varicocele, 55,56 which could lead to spermatozoal dysfunction. 57 Varicocelectomy has been shown to increase the concentrations of antioxidants such as superoxide dismutase, catalase, glutathione peroxidase, and vitamin C in seminal plasma and improve the sperm quality. 58 ROS levels were significantly higher in men with grade 2 and 3 varicocele compared to grade 1 but showed no correlation with testicular volumes.…”

Section: Varicocele and Osmentioning

confidence: 99%

REVIEW ARTICLE: Clinical Relevance of Oxidative Stress in Male Factor Infertility: An Update

Agarwal

Makker

Sharma

2007

American J Rep Immunol

688

507

View full text Add to dashboard Cite

Male factor has been considered a major contributory factor to infertility. Along with the conventional causes for male infertility such as varicocele, cryptorchidism, infections, obstructive lesions, cystic fibrosis, trauma, and tumors, a new, yet important cause has been identified: oxidative stress. Oxidative stress (OS) is a result of the imbalance between reactive oxygen species (ROS) and antioxidants in the body, which can lead to sperm damage, deformity and eventually male infertility. This involves peroxidative damage to sperm membrane and DNA fragmentation at both nuclear and mitochondrial levels. OS has been implicated as the major etiological factor leading to sperm DNA damage. OS‐induced DNA damage can lead to abnormalities in the offspring including childhood cancer and achondroplasia. In this article, we discuss the need of ROS in normal sperm physiology, the mechanism of production of ROS and its pathophysiology in relation to male reproductive system. The benefits of incorporating antioxidants in clinical and experimental settings have been enumerated. We also highlight the emerging concept of utilizing OS as a method of contraception and the potential problems associated with it.

show abstract

Section: Varicocele and Osmentioning

confidence: 99%

REVIEW ARTICLE: Clinical Relevance of Oxidative Stress in Male Factor Infertility: An Update

Agarwal

Makker

Sharma

2007

American J Rep Immunol

688

507

View full text Add to dashboard Cite

show abstract

“…The procedure was partly adapted from the method discribed by Ozbek et al [34] . Results were reported as per gram wet tissue.…”

Section: Behavioral Assessmentmentioning

confidence: 99%

Effects of resveratrol and methylprednisolone on biochemical, neurobehavioral and histopathological recovery after experimental spinal cord injury

Ateş

Çaylı

Altınöz

et al. 2006

Acta Pharmacologica Sinica

Self Cite

View full text Add to dashboard Cite

Aim: To investigate the neuroprotective effect of resveratrol in an experimental spinal cord injury (SCI) model in rats. Methods: Male Wistar albino rats weighing 200-250 g were randomized into six groups. Weight-drop trauma was performed for SCI. Group 1 underwent laminectomy alone. Group 2 underwent laminectomy followed by SCI. Groups 3, 4, 5, and 6 underwent laminectomy followed by SCI and received resveratrol (100 mg/kg), methylprednisolone (MP) (30 mg/kg), resveratrol (100 mg/kg) plus MP (30 mg/kg), and ethanol (2%), respectively. The rats were divided into two subgroups for biochemical analysis (killed at 24 h after surgery) and for neurobehavioral and histopathological evaluation (killed at 6 weeks after surgery). Posttraumatic neurological recovery after surgery was recorded weekly. Results: Groups 3 and 5 revealed significantly lower malondialdehyde, nitric oxide, xanthine oxidase, and higher glutathione levels than group 4 (P<0.05). Neurological recovery rates were significantly better in groups 3 and 5 than group 4 (P<0.05). When spinal trauma size ratios were compared, there was no significant difference between treatment groups. Conclusion: Resveratrol treatment revealed better biochemical recovery in the acute stage of trauma than MP treatment. Although resveratrol and combined treatment revealed better neurobehavioral recovery than MP treatment; resveratrol, MP, and combined treatment modalities improved histopathological recovery at the same level in the final stage of the experiment. Future studies involving different doses of resveratrol and different doses combinations with MP could promise better results as each drug has a different anti-oxidative mechanism of action.

show abstract

“…The homogenate was centrifuged at 10000 X g for 20 min at 4°C. All nitrate molecules in the supernatant were reduced to nitrites using nitrate reductase, and total nitrite levels were measured by the Griess reaction [20] with minor modifications. Total nitrite levels in the kidney were expressed as nmol/g wet tissue.…”

Section: Biochemical Analysismentioning

confidence: 99%

Protective effects of molsidomine against doxorubicin-induced renal damage in rats

Oğuz¹,

Beytur²,

Sarihan³

et al. 2016

CIM

View full text Add to dashboard Cite

Purpose: The purpose of this study was to investigate the therapeutic and protective effects of molsidomine (MLS) against doxorubicin (DOX)-induced renal damage in rats.Methods: Forty rats were randomly divided into five groups (control, MLS, DOX, DOX+MLS and MLS+DOX groups). Thiobarbituric acid reactive substance (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), nitric oxide (NO) and glutathione peroxidase (GPx) levels were determined from kidney tissues and blood urea nitrogen (BUN), creatinine (Cr) and albumin (Alb) levels also determined.Results: DOX treatment caused a significant increase in TBARS levels and a significant decrease in the GSH and CAT levels compared with the control group. In comparison, MLS administration before DOX injection caused a significant decrease in TBARS levels and also increases in GSH and CAT levels, whereas treatment of MLS after DOX injection did not show any beneficial effect on these parameters. All groups showed a significant increase in NO levels compared to the control group. There were no significant differences among the all groups for BUN and Cr levels. Serum level of Alb decreased in the DOX-treated groups when compared with control and MLS groups. The histopathological findings were in accordance with the biochemical results. MLS treatment reversed the DOX-induced kidney damage in group 4. MLS treatment before DOX injection exerted a protective effect against DOX-induced kidney damage.Conclusions: MLS shows promise as a possible therapeutic intervention for the prevention of kidney injury associated with DOX treatment. Additional studies are warranted.

show abstract

Increased Nitric Oxide Production in the Spermatic Vein of Patients with Varicocele

Cited by 98 publications

References 30 publications

REVIEW ARTICLE: Clinical Relevance of Oxidative Stress in Male Factor Infertility: An Update

REVIEW ARTICLE: Clinical Relevance of Oxidative Stress in Male Factor Infertility: An Update

Effects of resveratrol and methylprednisolone on biochemical, neurobehavioral and histopathological recovery after experimental spinal cord injury

Protective effects of molsidomine against doxorubicin-induced renal damage in rats

Contact Info

Product

Resources

About