Increased osteoprotegerin level is associated with impaired cardiovagal modulation in type-2 diabetic patients treated with oral antidiabetic drugs

Malhotra, Jasmine; Nanda, Nivedita; Sahoo, Jayaprakash; Velkumary, S; Pal, G K

doi:10.1186/s12872-020-01729-1

Cited by 6 publications

(9 citation statements)

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“…In our previous reports, we had described higher osteoprotegerin level in diabetes compared to healthy control despite standard treatment. [14] In this study, we report a similar pattern of higher OPG, T2D women with hypertension though it did not reach statistical significance between two disease groups, which might be due to a sample size. Our finding suggests that there might be a higher degree of vascular calcification in T2D patients when associated with hypertension.…”

Section: Resultscontrasting

confidence: 55%

The Hypertension among Women with Diabetes Mellitus Patients of Single Ethnicity within 10 Years of Treatment

Sailaja

Nanda

Suryanarayana

et al. 2021

IJCEP

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Background and Aim: Hypertension is often prevalent among diabetes patients. However, the risk factors of hypertension are mostly affected by age, gender, and ethnicity, which are non-modifiable. Therefore, in the present study, we have analyzed the prevalence of hypertension and various risk factors associated with it among women with diabetes mellitus from Tamilian community. Methods: We conducted a cross-sectional survey of type 2 diabetes mellitus patients in our Institute hospital. We recruited female patients with Tamil origin of three generations. The case history and personal history and basal demographic parameters were noted down. Five ml of fasting blood was collected for routine analysis. Plasma was stored for estimation of osteoprotegerin (OPG) and insulin. Results: Hypertension was associated with family history of cardiovascular disease (CVD), abdominal obesity, dyslipidemia and higher rate pressure product. Conclusion: Diabetes women of Tamil community and with family history of CVD may benefit from weight loss, lifestyle modification and monitoring of blood pressure in early part of life.

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Section: Resultscontrasting

confidence: 55%

The Hypertension among Women with Diabetes Mellitus Patients of Single Ethnicity within 10 Years of Treatment

Sailaja

Nanda

Suryanarayana

et al. 2021

IJCEP

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“…Yet, hypertension in diabetes attenuates the link of OPG to reduction in BRS (Table 4 ). Recently we have reported the link of increased level of OPG with decreased cardio-vagal modulation in T2D patients treated with oral antidiabetic drugs [ 25 ]. The findings of the present study corroborate with our earlier report of OPG as a marker of CV risks in diabetes, and in addition these findings indicate that TNF-α is a potential surrogate biomarker of CV risk in hypertensive patients with T2D on oral antidiabetic drugs.…”

Section: Discussionmentioning

confidence: 99%

“…The raised level of osteoprotegerin (OPG), a glycoprotein chiefly secreted from vascular smooth muscle cells and adipocytes, has been linked to atherosclerosis and CVD [ 24 ]. Our previous report depicts a positive association of OPG with decreased HRV in the Indian population with T2D [ 25 ]. However, it is unclear whether OPG is altered in T2D patients treated with oral antidiabetic and antihypertensive drugs.…”

Section: Introductionmentioning

confidence: 99%

Hypertension attenuates the link of osteoprotegerin to reduced baroreflex sensitivity in type 2 diabetes mellitus patients on oral antidiabetic and antihypertensive therapy – a cross sectional study

et al. 2022

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Purpose Decreased baroreflex sensitivity (BRS) has been shown to be a marker of cardiovascular (CV) risk. In the present study, the difference in CV risk biomarkers in type 2 diabetes (T2D) patients receiving oral antidiabetic drugs (OAD) with and without hypertension has been assessed. Materials and methods Ninety-two T2D patients on OAD without hypertension (control group) and eighty-eight diabetic patients with hypertension on OAD and antihypertensive drugs (test group) matched for age, gender, body mass index, serum glucose, glycated haemoglobin, and duration of the disease were recruited for the study. Their blood pressure (BP) variability including BRS, heart rate variability (HRV), insulin, lipid profile, osteoprotegerin (OPG), and tumor necrosis factor-α (TNF-α) were estimated. The association of various factors with BRS was assessed by Spearman correlation and multiple regression analysis. Results BRS was decreased (13.90 ± 5.27 vs 6.76 ± 4.58), HRV sympathetic indices [LFnu, LF-HF ratio (1.30 ± 0.49 vs 1.93 ± 0.62)], HOMA-IR, atherogenic index of plasma (AIP), OPG (223.08 ± 103.86 vs 287.60 ± 121.36) and TNF-α were increased, and parasympathetic indices [TP (1012.90 ± 316.18 vs 625.88 ± 229.84), RMSSD, SDNN, NN50, pNN50] were decreased in the test group compared to control group. In control group, parasympathetic indices, AIP, OPG, and TNF-α had a significant correlation and OPG had an independent association (β − 0.344; p 0.004) with BRS. In test group, BP, LF-HF ratio, parasympathetic indices, AIP, OPG, and TNF-α had significant correlation, and TNF-α alone (β − 0.297; p 0.022) had an independent contribution to decreased BRS. Conclusion Despite antidiabetic and antihypertensive treatments, T2D patients with hypertension had more cardiometabolic risks in comparison to normotensive T2D patients. Inflammation could be the inciting factor for rise in BP and decrease in BRS (CV risk) in hypertensive T2D patients. Hypertension in diabetes could attenuate the link of OPG to the reduction in BRS. Reduction in BRS could be a physiological marker of CV risk in T2D patients treated with OAD.

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“…OPG has also been linked to myocardial stiffness 11 , hypertension and diabetes 12 . Recently we have reported the link of OPG to CVD risk in diabetes 13 .…”

Section: Introductionmentioning

confidence: 99%

“…As BRS is influenced by mechanical properties of vascular wall, high vascular transmural pressure could alter the BRS and influences the autonomic regulation of blood pressure in diabetes with hypertension. Recently we have reported the plausible role of OPG in decreased cardiovagal modulation in diabetes 13 . Also, we have reported the link OPG with decreased BRS in patients with diabetes receiving oral anti-diabetic drugs 27 .…”

Section: Introductionmentioning

confidence: 99%

Association of rs2073618 polymorphism and osteoprotegerin levels with hypertension and cardiovascular risks in patients with type 2 diabetes mellitus

Sailaja,

Nanda,

Suryanarayana

et al. 2023

Sci Rep

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There are reports of link of osteoprotegerin (OPG) gene polymorphism to type-2 diabetes (T2D) and hypertension (HTN). The objective of the study was to assess the allele frequency of OPG (rs2073618) gene polymorphism and its association with heart rate variability (HRV) and blood pressure variability profile as CVD risks in diabetes mellitus patients with hypertension undergoing treatment. T2D patients on treatment without hypertension (n = 172), with hypertension (n = 177) and 191 healthy volunteers were recruited for the study. Their blood pressure variability including baroreflex sensitivity (BRS), heart rate variability (HRV), OPG, insulin, lipid profile, receptor-activator for NFkB (RANK), receptor-activator for NFkB-Ligand (RANKL), and tumor necrosis factor-α (TNF-α) were estimated. Allele frequency of OPG (rs2073618) gene polymorphism was assessed from the DNA samples. BRS and HRV indices were decreased, and RANKL/OPG and TNF-α were increased in T2D and T2D + HTN groups, respectively compared to healthy control group. The reduction in BRS was contributed by increased inflammation and reduced SDNN of HRV in GG genotype in T2D + HTN. In GG + GC subgroup, it was additionally contributed by rise in RANKL/OPG level (β − 0.219; p 0.008). Presence of mutant GG genotype contributed to the risk of hypertension among T2D patients (OR 3.004) as well as in general population (OR 2.79). It was concluded that CV risks are more in T2D patients with HTN expressing OPG rs2073618 gene polymorphism.

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Increased osteoprotegerin level is associated with impaired cardiovagal modulation in type-2 diabetic patients treated with oral antidiabetic drugs

Cited by 6 publications

References 50 publications

The Hypertension among Women with Diabetes Mellitus Patients of Single Ethnicity within 10 Years of Treatment

The Hypertension among Women with Diabetes Mellitus Patients of Single Ethnicity within 10 Years of Treatment

Hypertension attenuates the link of osteoprotegerin to reduced baroreflex sensitivity in type 2 diabetes mellitus patients on oral antidiabetic and antihypertensive therapy – a cross sectional study

Association of rs2073618 polymorphism and osteoprotegerin levels with hypertension and cardiovascular risks in patients with type 2 diabetes mellitus

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