Increased Overall Heart Rate Irregularity Risk by Hyperuricemia in the General Population: Results from the Korean National Health and Nutrition Examination Survey

Eun, Young‐Gyu; Han, Kyungdo; Kim, Da Hye; Kim, In Young; Park, Eun-Jung; Lee, Seulkee; Cha, Hoon‐Suk; Koh, Eun‐Mi; Lee, Jaejoon; Kim, Hyungjin

doi:10.3390/medicina56100501

Cited by 5 publications

(5 citation statements)

References 45 publications

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“…HU was also associated with a worse prognosis in patients after acute coronary disease [23,45]. Finally, the relationship between kidney disease and HU has been confirmed, which has already been described by other authors [46,47]. This relationship has a two-way effect between the two of them [48], where both the activation of inflammation [49] and the activation of the renin-angiotensin system [50] may be involved.…”

Section: Discussionsupporting

confidence: 66%

Prevalence of Hyperuricemia and Its Association with Cardiovascular Risk Factors and Subclinical Target Organ Damage

Antelo-Pais¹,

Prieto-Díaz²,

Micó-Pérez³

et al. 2022

JCM

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The role of uric acid levels in the cardiovascular continuum is not clear. Our objective is to analyze the prevalence of hyperuricemia (HU) and its association with cardiovascular risk factors (CVRF), subclinical target organ damage (sTOD), and cardiovascular diseases (CVD). We evaluated the prevalence of HU in 6.927 patients included in the baseline visit of the IBERICAN study. HU was defined as uric acid levels above 6 mg/dL in women, and 7 mg/dL in men. Using adjusted logistic regression models, the odds ratios were estimated according to CVRF, sTOD, and CVD. The prevalence of HU was 16.3%. The risk of HU was higher in patients with pathological glomerular filtration rate (aOR: 2.92), heart failure (HF) (aOR: 1.91), abdominal obesity (aOR: 1.80), hypertension (HTN) (aOR: 1.65), use of thiazides (aOR: 1.54), left ventricular hypertrophy (LVH) (aOR: 1.36), atrial fibrillation (AFIB) (aOR: 1.29), and albuminuria (aOR: 1.27). On the other hand, being female (aOR: 0.82) showed a reduced risk. The prevalence of HU was higher in men, in patients presenting CVRF such as HTN and abdominal obesity, and with co-existence of LVH, atrial fibrillation (AFIB), HF, and any form of kidney injury. These associations raise the possibility that HU forms part of the early stages of the cardiovascular continuum. This may influence its management in Primary Healthcare because the presence of HU could mean an increased CV risk in the patients.

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Section: Discussionsupporting

confidence: 66%

Prevalence of Hyperuricemia and Its Association with Cardiovascular Risk Factors and Subclinical Target Organ Damage

Antelo-Pais¹,

Prieto-Díaz²,

Micó-Pérez³

et al. 2022

JCM

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“…Moreover, the sUA level was significantly associated with AF in the general Japanese population [19]. Hyperuricemia was found to increase the risk of heart rate irregularity in the Korean National Health and Nutrition Examination Survey [20]. Our study shows that an elevated concentration of sUA intensifies this effect.…”

Section: Discussionmentioning

confidence: 50%

Hyperuricemia as a Risk Factor in Hypertension among Patients with Very High Cardiovascular Risk

Muszyński,

Dąbrowski,

Pasławska

et al. 2023

Healthcare

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Hypertension remains a global threat to public health, affecting the worldwide population. It is one of the most common risk factors for cardiovascular disease. Today’s treatments focus on creating a hypotensive effect. However, there is a constant search for additional factors to reduce the potential of developing hypertension complications. These factors may act as a parallel treatment target with a beneficial effect in specific populations. Some studies suggest that uric acid may be considered such a factor. This study investigated the potential effect of uric acid concentrations over 5 mg/dL on the incidence of hypertension complications among patients with very high cardiovascular risk. A total of 705 patients with hypertension and very high cardiovascular risk were selected and included in the analysis. The patients were divided and compared according to serum uric acid levels. The study showed a higher occurrence of heart failure (OR = 1.7898; CI: 1.2738–2.5147; p = 0.0008), atrial fibrillation (OR = 3.4452; CI: 1.5414–7.7002; p = 0.0026) and chronic kidney disease (OR = 2.4470; CI: 1.3746–4.3558; p = 0.0024) among individuals with serum uric acid levels over 5 mg/dL, males and those with a BMI > 25 kg/m2. These findings suggest that even serum uric acid concentrations over 5 mg/dL may affect the prevalence of hypertension-related complications among patients with very high cardiovascular risk.

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“…Be to, 2020 m. paskelbtame Korėjos nacionaliniame sveikatos ir mitybos tyrime, ištyrus beveik 11 000 suaugusiųjų, apskaičiuota, kad nereguliari širdies veikla triskart dažniau nustatoma pacientams su hiperurikemija nei tiems, kurių serumo šlapimo rūgšties koncentracija yra normali. Tame pačiame tyrime pažymima, jog hipertenzija kartu su hiperurikemija turi sinergistinį poveikį širdies aritmijų pasireiškimui [31]. Manoma, kad tam turi įtakos oksidacinis stresas ir endotelio disfunkcija, tačiau reikalingi išsamesni tyrimai, paaiškinantys ryšio tarp hiperurikemijos, AKS ir aritmijų biologinius mechanizmus [4].…”

Section: Diskusijaunclassified

Besimptomė Hiperurikemija Ir Nutukimas. Klinikinis Atvejis

Marčiulynaitė¹,

Šnipaitienė²,

Jankauskaitė³

2022

Health Sciences

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Hiperurikemija, arba šlapimo rūgšties perteklius kraujyje, yra sąlyginai dažnas laboratorinių tyrimų radinys ne tik suaugusiųjų, bet ir vaikų amžiuje, ypač nutukusiems asmenims, esant padidėjusiam arteriniam kraujospūdžiui, metaboliniam sindromui ar lėtinei inkstų ligai. 90 proc. hiperurikemijos atvejų lemia sutrikęs šlapimo rūgšties šalinimas per inkstus, kitą dalį sudaro padidėjusi šlapimo rūgšties gamyba, skylant purinams. Perteklinė serumo uratų koncentracija ilgainiui gali sukelti inkstų akmenligę ar podagrą, todėl svarbu atrinkti pacientus, kuriems reikalingas šlapimo rūgšties kiekį mažinantis gydymas. Besimptomės hiperurikemijos korekcija pradedama nuo dietos su sumažintu purinų kiekiu maiste ir rizikos veiksnių šalinimo (pvz., antsvorio mažinimo). Nors apibrėžto sutarimo dėl gydymo reikalaujančios ribinės šlapimo rūgšties koncentracijos nėra, medikamentai, tokie kaip alopurinolis, besimptomės hiperurikemijos atveju skiriami tik esant itin ženkliam serumo uratų kiekio padidėjimui. Šiame straipsnyje aptarsime besimptomės hiperurikemijos, nustatytos nutukusiai paauglei, klinikinį atvejį, pasireiškusį kartu su keletą metų stebimu uždegiminių rodiklių padidėjimu nesant lėtinės infekcijos požymių, skilveline ekstrasistolija ir vitamino D stoka, bei pateiksime besimptomės hiperurikemijos vaikų amžiuje literatūros analizę.

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Increased Overall Heart Rate Irregularity Risk by Hyperuricemia in the General Population: Results from the Korean National Health and Nutrition Examination Survey

Cited by 5 publications

References 45 publications

Prevalence of Hyperuricemia and Its Association with Cardiovascular Risk Factors and Subclinical Target Organ Damage

Prevalence of Hyperuricemia and Its Association with Cardiovascular Risk Factors and Subclinical Target Organ Damage

Hyperuricemia as a Risk Factor in Hypertension among Patients with Very High Cardiovascular Risk

Besimptomė Hiperurikemija Ir Nutukimas. Klinikinis Atvejis

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