Increased oxidative activity from hydrogen peroxide may be the cause of the predisposition to cataracts among patients with atopic dermatitis

Namazi, Mohammad Reza; Handjani, Farhad; Amirahmadi, Mousa

doi:10.1016/j.mehy.2005.11.001

Cited by 4 publications

(6 citation statements)

References 8 publications

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“…5,10,14,15 These pathogenic factors have been more strongly related to age-related and cortical cataract formation, 14 but some authors have proposed their role in AD patients with cataracts. There have been theories relating ASC formation with increased inflammatory markers, such as interleukin 6 (IL-6), tumor necrosis factor, 16 and transforming growth factor ␤.…”

Section: Clinical Severitymentioning

confidence: 99%

“…12,13 Oxidative Stress Consumption of antioxidants, retinal peroxidation, and increasing production of free radicals have been proposed as pathogenic mechanisms in human cataractogenesis. 5,10,14,15 These pathogenic factors have been more strongly related to age-related and cortical cataract formation, 14 but some authors have proposed their role in AD patients with cataracts. There have been theories relating ASC formation with increased inflammatory markers, such as interleukin 6 (IL-6), tumor necrosis factor, 16 and transforming growth factor ␤.…”

Section: Clinical Severitymentioning

confidence: 99%

“…Importantly, these findings were not observed in patients with other forms of dermatitis (eg, psoriasis) who had been receiving prolonged topical corticosteroid therapy. 10,15 Corticosteroid Therapy Systemic corticosteroids are known to cause a wide range of ocular complications. The relationship between systemic corticosteroid use and the development cataracts was first reported in 1960.…”

Section: Clinical Severitymentioning

confidence: 99%

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Cataracts in Atopic Dermatitis

Bair

Dodd²,

Heidelberg³

et al. 2011

Arch Dermatol

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Background: Atopic dermatitis (AD) is a common skin disorder of increasing prevalence. Many ophthalmologic conditions are associated with AD, including cataract formation. Posterior and anterior subcapsular cataracts have been described in AD. Topical and systemic corticosteroids have been implicated in the development of cataracts. The precise pathogenic mechanisms and risk factors for development of atopic cataract are not clear.Observation: We report a case of cataract development in a child with severe AD and performed an extensive review of the dermatologic and ophthalmologic literature pertaining to AD and cataract formation. The incidence, demographics, pathogenesis, and characteristics of atopic cataracts are evaluated.Conclusions: Atopic dermatitis alone is a risk factor to develop both posterior and anterior subcapsular cataracts. There is a slightly increased probability of posterior subcapsular cataracts. However, anterior subcapsular cataracts are more specific to AD. A positive correlation was found between atopic cataract development and a decreased inducibility of superoxide dismutase. This suggests that atopic cataract development is correlated with oxidative damage of the lens and related to chronic inflammation.

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Section: Clinical Severitymentioning

confidence: 99%

Section: Clinical Severitymentioning

confidence: 99%

Section: Clinical Severitymentioning

confidence: 99%

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Cataracts in Atopic Dermatitis

Bair

Dodd²,

Heidelberg³

et al. 2011

Arch Dermatol

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“…The patho-physiology of cataract development in AD is multi-factorial. Evidence based scientific reports have shown that patients with AD have breached blood retinal barrier and high levels of free radicals in 30,31 the lens suggestive of oxidative damage. Steroids in any form can cause cataract formation but mostly the oral form are strongly associated with cataractous changes in the lens, however steroids in the form of inhalers and topical creams/ointments 26,32 are also responsible for cataract development.…”

Section: Glaucomamentioning

confidence: 99%

Ophthalmic Complications Associated with Atopic Dermatitis: A Review

Ahmad¹

2022

JIIMC

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Atopic dermatitis (AD) is a long-lasting dermatological disease that is associated with ophthalmic complications in the long run. Those having AD are more likely at risk of developing comorbidities in eye as compared to normal persons. This review encompasses the clinical manifestations, pathophysiology and treatment of common ophthalmic complications presented with AD i.e., blepharitis, kerato-conjunctivitis, corneal ectasias, glaucomatous eyes, lens opacification, detachment of retina, herpetic eye disease (HED) and dupilumab associated eye toxicities. It is necessary for dermatology colleagues to be vigilant enough not to miss ophthalmic problems associated with AD, as an early detection and management can save the vision.

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“…3 It has been hypothesized that increased oxidative activity in the anterior chamber of the eye in patients with AD is involved in the formation of their cataracts. 4 In addition, many of these children likely develop cataracts as an adverse effect of treatment with systemic steroids.…”

Section: Invited Commentarymentioning

confidence: 99%