Increased plasma leptin/fat ratio in patients with chronic renal failure: a cause of malnutrition?

Young, Gerald A.; Woodrow, Graham; Kendall, Stephan DiSean; Oldroyd, B.; Turney, J. H.; Brownjohn, A. M.; Smith, Margaret A.

doi:10.1093/ndt/12.11.2318

Cited by 99 publications

(74 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It should be stressed that many protein-bound uremic solutes have important pathophysiologic actions and might be subject to a similar enhancement of toxicity in the case of hypoalbuminemia. Candidate molecules are indoxyl sulfate (6,33,34 ), indole 3-acetic acid (35,36 ), 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (37,38 ), phenol (39 ), advanced glycation end products (40 -42 ), leptin (43,44 ), homocysteine (45,46 ), hippuric acid (47,48 ), and p-hydroxyhippuric acid (49,50 ).…”

Section: Discussionmentioning

confidence: 99%

Toxicity of Free p-Cresol: A Prospective and Cross-Sectional Analysis

et al. 2003

View full text Add to dashboard Cite

Background: Uremic syndrome is the consequence of the retention of solutes usually cleared by the healthy kidneys. p-Cresol can be considered a prototypic protein-bound uremic toxin. It is conceivable, analogous with drugs, that the non-protein-bound fraction of pcresol exerts toxicity. This aspect had never been evaluated, nor have the factors influencing the free fraction of p-cresol. Methods: In a transsectional study we evaluated the relationship between prehemodialysis free p-cresol and the ratio of free to total p-cresol (F:T) to clinical and biological factors in 44 chronic renal failure patients. The evolution of free p-cresol was assessed prospectively in 12 patients showing a change in serum albumin of at least 5 g/L over time. Hospitalization days attributable to infection and the free p-cresol concentrations were noted over a 1-year period. The impact of free p-cresol in vitro on leukocyte functional capacity was evaluated by chemiluminescence. Results: We observed a correlation between total and free p-cresol (r ‫؍‬ 0.84; P <0.001). In the multivariate analyses, free p-cresol and F:T showed a negative correlation with albumin. A shift from normal serum albumin to hypoalbumininemia in 12 patients led to an increase in free p-cresol from 5.9 ؎ 3.2 to 8.2 ؎ 4.5 mol/L (P <0.05; 0.64 ؎ 0.35 to 0.89 ؎ 0.49 mg/L). Free p-cresol (P <0.05) was higher in the patients hospitalized for infectious disease. In vitro, free p-cresol was higher in a 25 g/L than in a 50 g/L albumin solution (P <0.05). Leukocyte chemiluminescence production was more inhibited in the low albumin (high free p-cresol) solution (28% ؎ 6% vs 21% ؎ 8%; P <0.05).

show abstract

Section: Discussionmentioning

confidence: 99%

Toxicity of Free p-Cresol: A Prospective and Cross-Sectional Analysis

et al. 2003

View full text Add to dashboard Cite

show abstract

“…This suggests that weight loss and anorexia in chronic wasting diseases might be linked with leptin. The ESRD patients are associated with hyperleptinemia, suggesting hyperleptinemia stimulated feedback inhibition (Nordfors et al 1998) as a cause of anorexia and decreased food intake (Young et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Association of genetic variants of ghrelin, leptin and UCP2 with malnutrition inflammation syndrome and survival in end-stage renal disease patients

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Thus we used the leptin/ fat ratio in most of our analyses. Similarly, in the study by Young et al, the leptin / fat mass ratio was used and found as an important indicator of malnutrition (9).…”

Section: Discussionmentioning

confidence: 99%

Leptin Parameters are Associated with Inflammation and Both Anthropometric and Serum Markers of Protein-Energy Wasting in Hemodialysis Patients

Öztürk¹,

Erdemoğlu²,

Özberk³

et al. 2014

Turk Neph Dial Transpl

View full text Add to dashboard Cite

ObJeCtIVe: Protein-energy wasting (PEW) and inflammation are common and related to increased cardiovascular mortality in hemodialysis (HD) patients. Herein, we aimed to investigate the relationships between adipocytokines, inflammation and serum and anthropometric markers of PEW syndrome in HD patients. mAterIAl and metHOds: Seventy-four HD patients (mean age=62±13 years, male/female=44/30) were enrolled. Serum leptin, adiponectin and IL-6 levels were measured by ELISA. Anthropometric measurements such as triceps skin fold thickness (TSFT), mid-arm circumference (MAC) were performed. Bioelectrical impedance analysis was also done. The degree of malnutrition was evaluated with subjective global assessment (SGA). results:The leptin/fat ratio was associated with serum IL-6 (r=0.32, p=0.008), serum albumin (r= -0.37, p=0.002) and TSFT (r= -0.41, p=0.001). Serum adiponectin levels were positively correlated with serum albumin (r=0.29,p=0.01) and negatively associated with the leptin/fat ratio (r= -0.30, p=0.01). Serum CRP levels were significantly lower in the high adiponectin group (1.20 ±0.92 vs 2.02 ±2.18 µg/mL, p=0.042). On linear regression analysis for predicting the leptin/fat ratio, gender and serum albumin were retained as significant in the model. bulGulAr: Leptin / yağ oranının serum 32, p=0,008) ve serum albumin (r= -0,37, p=0,002) seviyeleri ve TSFT (r= -0,41, p=0,001) ile ilişkili olduğu görüldü. Serum adiponektin düzeyleri serum albumini (r=0,29, p=0,01) ile pozitif korele ve leptin/yağ oranı (r= -0,30, p=0,01) ile negatif korele bulundu. Yüksek adiponektin düzeyi olan grupta serum CRP düzeyleri anlamlı olarak düşük bulundu (1,20 ± 0,92 vs 2,02 ± 2,18 µg/mL, p=0,042). Modelde leptin /yağ oranının prediktif değeri için yapılan lineer regresyon analizinde cinsiyet ve serum albümin değeri anlamlı kalmaya devam etti. türk nefroloji diyaliz ve transplantasyon dergisi Turkish Nephrology, Dialysis and Transplantation Journal

show abstract

Increased plasma leptin/fat ratio in patients with chronic renal failure: a cause of malnutrition?

Cited by 99 publications

References 9 publications

Toxicity of Free p-Cresol: A Prospective and Cross-Sectional Analysis

Toxicity of Free p-Cresol: A Prospective and Cross-Sectional Analysis

Association of genetic variants of ghrelin, leptin and UCP2 with malnutrition inflammation syndrome and survival in end-stage renal disease patients

Leptin Parameters are Associated with Inflammation and Both Anthropometric and Serum Markers of Protein-Energy Wasting in Hemodialysis Patients

Contact Info

Product

Resources

About