Increased prevalence of elevated serum IgE and IgG 4 antibodies in students over a decade

Nakagawa, Takemasa; Nakagomi, Toyoko; Hisamatsu, Shun’ichi; Itaya, Hideki; Nakagomi, Osamu; Mizushima, Yutaka

doi:10.1016/s0091-6749(96)70272-5

Cited by 18 publications

(15 citation statements)

References 5 publications

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“…It has been suggested that variations in IgE levels and atopy between populations are due to differences in climate or levels of urbanization [13]. Increasing urbanization has also been postulated as a cause of rising IgE levels over time [12]. Our study does not support these hypotheses as neither geographical region nor urban versus rural location had a significant independent relationship with either total or HDM‐specific IgE levels.…”

Section: Discussioncontrasting

confidence: 82%

“…A longitudinal study from Tucson, Arizona observed an age‐related decline in total IgE which was greatest in the under 35s and in atopic subjects [11]. A study in Japan showed that raised HDM IgE became more prevalent amongst 13–14‐year‐old girls over a 10‐year period, suggesting that successive cohorts may be at increasing risk of allergic sensitization in childhood [12].…”

Section: Discussionmentioning

confidence: 99%

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The descriptive epidemiology of house dust mite‐specific and total immunoglobin E in England using a nationally representative sample

Court

Cook

Strachan

2002

Clin Experimental Allergy

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Section: Discussioncontrasting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

The descriptive epidemiology of house dust mite‐specific and total immunoglobin E in England using a nationally representative sample

Court

Cook

Strachan

2002

Clin Experimental Allergy

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“…Standardized diesel exhaust particles (DEP) (National Institute of Standards, Gaithersburg, MD) and carbon black (the kind gift of Dr Joe Mauderly of the Inhalation Toxicology Research Institute) were suspended at 1 mg/ml and further diluted in sterile RPMI (Gibco/BRL). The dose of DEP (1–100 ng/ml) was based on previous reports [2–9]. LPS (Sigma) was serially diluted in RPMI from 1 mg/ml.…”

Section: Methodsmentioning

confidence: 99%

“…The health effects of particulate air pollution include the increased prevalence of lower respiratory tract symptoms, decrements in PEF, and increased bronchodilator use and ER visits for respiratory disease [1,2]. The increased prevalence of allergic respiratory disease has been partly attributed to respirable particulates [3–5]. DEP‐induced respiratory effects have been associated with changes in inflammatory cytokines, which suggest possible mechanisms of action.…”

Section: Introductionmentioning

confidence: 99%

The influence of diesel exhaust particles on mononuclear phagocytic cell-derived cytokines: IL-10, TGF-βand IL-1β

Pacheco

Tarkowski

Sterritt

et al. 2001

Clinical and Experimental Immunology

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SUMMARYDiesel exhaust particles (DEP) are known to modulate the production of cytokines associated with acute and chronic respiratory symptoms and allergic respiratory disease. Tolerance is an important mechanism through which the immune system can maintain nonresponsiveness to common environmental antigens. We examined the effect of DEP on IL-10 and TGF-b , cytokines produced by macrophages and repressor (Tr-like) lymphocytes which influence tolerance. Human PBMCs (n 22) were incubated with 1± 100 ng/ml of DEP, and suboptimally primed with LPS. IL-10 gene expression was assessed by the S1 nuclease protection assay, and production of IL-10, TGF-b , TNF-a , IL-1b and IL-4 stimulated CD23 was evaluated by ELISA after 24 and 48 h. The effect of the order of exposure to DEP and LPS was evaluated on IL-10 protein and mRNA in cells (1) preincubated with LPS followed by DEP, or (2) exposed first to DEP followed by LPS. IL-10 was further evaluated using benzo[a]pyrene and [a ]naphthoflavone as a surrogate for the polyaromatic hydrocarbons (PAHs) adsorbed to DEP. Control cells were incubated with carbon black, without PAHs. In PBMCs exposed to DEP with LPS, or preincubated with LPS before DEP, IL-10 production and mRNA fall significantly. TGF-b is similarly suppressed, IL-1b secretion is significantly stimulated, and IL-4 stimulated CD23 release rises in the atopic subjects. In contrast, when DEP is added prior to LPS, IL-10 production rises, and IL-1b falls to zero. These effects on IL-10 are reproduced with benzo[a]pyrene and reversed by the coaddition of [a ]naphthoflavone, its known antagonist. The carbon black fraction has no effect on IL-10 production. The effect of DEP on IL-10 can be inhibitory or stimulatory, depending on the order of exposure to DEP and LPS. Pro-inflammatory cytokines and factors rise when IL-10 is inhibited, and are suppressed when IL-10 is stimulated. These results are duplicated with benzo[a]pyrene, suggesting that the PAH portion of the DEP is the active agent.

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“…Indeed, selfreports on symptoms of atopic disease, combined with relevant objective measurements, reactivity in skin prick tests [2], or concentrations of specific IgE and IgG4 antibodies in serum [3], have consistently suggested a true increase in their prevalence. A recent cross-sectional study evaluated randomly selected people born before, during, and after World War II, and, therefore, were exposed to markedly different diets and living conditions in their infancy [4], which is considered a critical period for the consolidation of the immune responder type.…”

Section: Introductionmentioning

confidence: 99%

Dietary modification of atopic disease: Use of probiotics in the prevention of atopic dermatitis

Isolauri

2004

Curr Allergy Asthma Rep

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The increased prevalence of atopic diseases, atopic dermatitis, allergic rhinitis, and asthma has been described as an epidemic. New approaches in the fight against allergic diseases are called for, the target being the persistence of the atopic T helper 2-skewed immune responder pattern beyond infancy. Atopic dermatitis, the earliest of these conditions, might act as a portal for the development of IgE-mediated atopic manifestations. Abundant evidence implies that specific strains selected from the healthy gut microbiota exhibit powerful antipathogenic and anti-inflammatory capabilities, and several targets for the probiotic approach have emerged in atopic dermatitis: degradation/structural modification of enteral antigens, normalization of the properties of aberrant indigenous microbiota and of gut barrier functions, regulation of the secretion of inflammatory mediators, and promotion of the development of the immune system. Better understanding of the effects of different probiotic strains and deeper insight into the mechanisms of the heterogeneous manifestations of atopic disease are needed for the validation of specific strains carrying anti-allergic potential.

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Increased prevalence of elevated serum IgE and IgG 4 antibodies in students over a decade

Cited by 18 publications

References 5 publications

The descriptive epidemiology of house dust mite‐specific and total immunoglobin E in England using a nationally representative sample

The descriptive epidemiology of house dust mite‐specific and total immunoglobin E in England using a nationally representative sample

The influence of diesel exhaust particles on mononuclear phagocytic cell-derived cytokines: IL-10, TGF-βand IL-1β

Dietary modification of atopic disease: Use of probiotics in the prevention of atopic dermatitis

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