Increased prevalence of psoriasis in patients with coronary artery disease: results from a case–control study

Abstract

The prevalence of psoriasis is twofold higher in patients with CAD than in control patients without CAD. It is associated with a more severe coronary artery involvement.

Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from γδ-T cells

“…Systemic inflammation induced by obesity and metabolic syndrome, in turn, could exacerbate local skin inflammation via blood flow, which may consequently expand psoriasis inflammation 12 . The link between local and systemic inflammation is further supported by recent vast reports focusing on the high percentages of psoriasis patients who have cardiovascular and metabolic comorbidities [12][13][14][15][16][17] .…”

Is psoriasis a risk factor of angiography-proven coronary artery disease?

“…Angiography, including invasive coronary angiography and noninvasive computed tomography angiography, provides a high‐quality imaging modality to measure CAD directly, and is regarded as the gold standard for diagnosis of CAD. Several studies have been done to assess CAD using angiography in patients with psoriasis, but the results are inconsistent or even contradictory . Therefore, we conducted this meta‐analysis to evaluate the prevalence of CAD in patients with psoriasis and the association between psoriasis and CAD.…”

“…Subsequently, 16 articles were excluded because they did not use angiography to assess CAD or did not describe the outcomes of interest. Finally, six observational studies met all of the inclusion criteria.…”

“…In these studies, over 60% of patients with psoriasis were male, with a mean age of 41–61 years. Overall, patients had a mean disease duration of > 15 years . Three studies reported the mean Psoriasis Area and Severity Index, which ranged from 5.7 to 13.9 .…”

“…Six studies with 510 patients with psoriasis were included in the analysis to assess the prevalence of CAD. The pooled estimated prevalence of CAD among patients with psoriasis was 51.1% (95% confidence interval 27.2–75.1) (Fig.…”