Abstract:Recombinant adeno-associated virus (rAAV) has established itself as a
highly efficacious gene delivery vector with a well characterised safety
profile allowing broad clinical application. Recent successes in
rAAV-mediated gene therapy clinical trials will continue to drive demand
for improved rAAV production processes to reduce costs. Here we
demonstrate that small molecule bioactive chemical additives can
significantly increase recombinant AAV vector production by HEK cells up
to 3-fold. Nocodazole (an anti-m… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.