Increased regional gray matter atrophy and enhanced functional connectivity in male multiple sclerosis patients

Sanchis‐Segura, Carles; Cruz-Gómez, Álvaro Javier; Belenguer, Antonio; Márquez, M.S. Fittipaldi; Ávila, César; Forn, Cristina

doi:10.1016/j.neulet.2016.07.028

Cited by 16 publications

(11 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lesion volumes did not differ significantly between male and female patients, but in male patients only, larger lesion volume was associated with lower cognitive performance on test scores averaged across seven domains (executive functioning, verbal memory, processing speed, visuospatial memory, working memory, attention, psychomotor speed). More recent cross-sectional work using VBM, however, showed a somewhat different pattern of sex effects between patients and controls in subcortical volumes (Sanchis-Segura et al, 2016;Voskuhl et al, 2020). Similar to Schoonheim et al (2012) and Voskuhl et al (2020) (79 RRMS, 10 SPMS, 45 controls, ages 18-69), Sanchis-Segura et al (2016) (56 RRMS, 63 controls, ages 18-61) reported smaller thalamus volumes in both male and female MS patients compared to controls, as well as smaller putamen volumes specifically in male patients than male controls.…”

Section: Multiple Sclerosismentioning

confidence: 86%

See 1 more Smart Citation

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Salminen

Tubi

Bright

et al. 2021

Human Brain Mapping

View full text Add to dashboard Cite

Sex is a biological variable that contributes to individual variability in brain structure and behavior. Neuroimaging studies of population-based samples have identified normative differences in brain structure between males and females, many of which are exacerbated in psychiatric and neurological conditions. Still, sex differences in MRI outcomes are understudied, particularly in clinical samples with known sex differences in disease risk, prevalence, and expression of clinical symptoms. Here we review the existing literature on sex differences in adult brain structure in normative samples and in 14 distinct psychiatric and neurological disorders. We discuss commonalities and sources of variance in study designs, analysis procedures, disease subtype effects, and the impact of these factors on MRI interpretation. Lastly, we identify key problems in the neuroimaging literature on sex differences and offer potential recommendations to address current barriers and optimize rigor and reproducibility. In particular, we emphasize the importance of large-scale neuroimaging initiatives such as the Enhancing NeuroImaging Genetics through Meta-Analyses consortium, the UK Biobank, Human Connectome Project, and others to provide unprecedented power to evaluate sex-specific phenotypes in major brain diseases.

show abstract

Section: Multiple Sclerosismentioning

confidence: 86%

“…In contrast to Schoonheim et al ( 2012), case-control differences in other subcortical structures were not detected. Surprisingly, neither Voskuhl et al (2020) nor Sanchis-Segura et al (2016) offered any potential explanation for these discrepant studies despite the very limited number of MS studies that have examined sex effects.…”

Section: Multiple Sclerosismentioning

confidence: 94%

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Salminen

Tubi

Bright

et al. 2021

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…The co-localization of structural and functional abnormalities is well documented across neuropsychiatric diseases. Numerous disorders, including Parkinson's disease (24), Alzheimer's disease (25), primary progressive apraxia (26), multiple sclerosis (27,28), schizophrenia (29), and mood disorders, including major depressive disorder and bipolar disorder (30,31), have demonstrated conjoint abnormalities of brain function and structure, and recent research has investigated this relationship in major depression specifically (32,33). The concordance of structural and functional abnormalities in neurodegenerative diseases underlies the network degeneration hypothesis (34)(35)(36), for which major depression is also being investigated as a potentially network-based disorder (37)(38)(39)(40).…”

mentioning

confidence: 99%

Multimodal Abnormalities of Brain Structure and Function in Major Depressive Disorder: A Meta-Analysis of Neuroimaging Studies

Gray

Müller

Eickhoff

et al. 2020

AJP

332

158

View full text Add to dashboard Cite

Objective-Imaging studies of major depressive disorder have reported structural and functional abnormalities in a variety of spatially diverse brain regions. Quantitative meta-analyses of this literature, however, have failed to find statistically significant between-study spatial convergence, other than transdiagnostic-only effects. In the present study, the authors applied a novel multimodal meta-analytic approach to test the hypothesis that major depression exhibits spatially convergent structural and functional brain abnormalities. Methods-This coordinate-based meta-analysis included voxel-based morphometry (VBM) studies and resting-state voxel-based pathophysiology (VBP) studies of blood flow, glucose metabolism, regional homogeneity, and amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF). Input data were grouped into three primary meta-analytic classes: gray matter atrophy, increased function, and decreased function in patients with major depression relative to healthy control subjects. In secondary meta-analyses, the data were grouped across primary categories, and in tertiary analyses, by medication status and absence of psychiatric comorbidity. Activation likelihood estimation was used for all analyses.

show abstract

“…Indeed, MMS had more widespread regional GM damage ( 24 ). Accordingly, WMS showed a more localized patter of regional GM when compared to MMS in the study of Sanchis-Segura ( 26 ). In this study, however, MMS exhibited additional decreased GM volume only in bilateral frontal areas.…”

Section: Sex-related Brain Gm Damagementioning

confidence: 91%

“…In this study, however, MMS exhibited additional decreased GM volume only in bilateral frontal areas. Sex-related MRI studies discrepancies regarding topographical distribution of regional GM atrophy may be related to sample size and MS clinical and demographics characteristics ( 24 , 26 ). Using regional volumetry analysis, distinct topographical distribution of regional GM atrophy has been shown to differentiate MS patients also according to cognitive dysfunction ( 11 ).…”

Section: Sex-related Brain Gm Damagementioning

confidence: 99%

Structural and functional brain damage in women with multiple sclerosis: A mini-review of neuroimaging sex-based studies

Ceccarelli

2022

Front. Neurol.

View full text Add to dashboard Cite

Neuroimaging literature in healthy humans has shown that there are sex-related differences in healthy brain's anatomical structure, associated function and susceptibility to neurological diseases. This mini-review summarizes findings derived from the current neuroimaging studies focused on sex-related brain structural and functional damage in women with multiple sclerosis (MS). MS is a chronic, multifactorial, immune-mediated disorder of the central nervous system that affects mostly women. Even if recent neuroimaging studies have shed light on distinctive features of sex-related MS differences in brain structural and functional damage, more research is needed to better elucidate sex-related MS pathological changes and susceptibility and to implement sex-tailored treatment strategies in MS.

show abstract

Increased regional gray matter atrophy and enhanced functional connectivity in male multiple sclerosis patients

Cited by 16 publications

References 15 publications

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Multimodal Abnormalities of Brain Structure and Function in Major Depressive Disorder: A Meta-Analysis of Neuroimaging Studies

Structural and functional brain damage in women with multiple sclerosis: A mini-review of neuroimaging sex-based studies

Contact Info

Product

Resources

About