Increased Risk for Obesity and Diabetes with Neurodegeneration in Developing Countries

Martins, Ian James

doi:10.4172/1747-0862.s1-001

Cited by 25 publications

(14 citation statements)

References 148 publications

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“…Besides, recent nutrigenomics data show that the interaction between genes and food bioactive compounds can positively or negatively influence an individual’s health and possibly will aid with the prescription of customized diets according to an individual’s genotype. Thus, the next approaches to clinical research with polyphenols should consider that dietary bioactive compounds such as polyphenols can be attributed to epigenetic mechanisms such as the regulation of histone deacetylases (HDAC) and histone acetyltransferase (HAT) activities and acetylation of histones and non-histone chromatin proteins [255,256].…”

Section: Discussionmentioning

confidence: 99%

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

Renaud

Martinoli

2019

IJMS

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Over the last two decades, the increase in the incidence of neurodegenerative diseases due to the increasingly ageing population has resulted in a major social and economic burden. At present, a large body of literature supports the potential use of functional nutrients, which exhibit potential neuroprotective properties to mitigate these diseases. Among the most studied dietary molecules, polyphenols stand out because of their multiple and often overlapping reported modes of action. However, ambiguity still exists as to the significance of their influence on human health. This review discusses the characteristics and functions of polyphenols that shape their potential therapeutic actions in neurodegenerative diseases while the less-explored gaps in knowledge of these nutrients will also be highlighted.

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Section: Discussionmentioning

confidence: 99%

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

Renaud

Martinoli

2019

IJMS

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“…Although direct fruit peel monitoring of xenobiotics is currently available by exposing it (without any pretreatment) to direct analysis in real time coupled to a high-resolution orbitrap mass spectrometer [106]. On the other hand, nutritional diets (plant versus meat) are designed to maintain the toxicological processing of xenobiotics with the critical role of liver xenobiotic enzymes (cytochrome P450 or CYP450) in their metabolism [87]. Xenobiotics are metabolized first by a phase I system (CYP450) which modifies the compounds so that they have hydrophilic functional groups for increased solubility [107].…”

Section: Potential Use Of Amazonian Fruits In Metabolic Disordersmentioning

confidence: 99%

“…Diets that contain appropriate protein quality, carbohydrate and lipid (polyunsaturated) content as well as minerals and vitamins (e.g. nicotinamide, riboflavin, niacin, folic acid, vitamin E) are essential for xenobiotic metabolism [87]. All these attributes of nutritional dense foods are present in Amazonian fruits and could potentially diminish the rapid xenobiotic metabolism triggered by low-calorie diets and poor nutrition [87].…”

Section: Potential Use Of Amazonian Fruits In Metabolic Disordersmentioning

confidence: 99%

“…nicotinamide, riboflavin, niacin, folic acid, vitamin E) are essential for xenobiotic metabolism [87]. All these attributes of nutritional dense foods are present in Amazonian fruits and could potentially diminish the rapid xenobiotic metabolism triggered by low-calorie diets and poor nutrition [87]. Finally, genotoxic stress is defined as the induction (e.g.…”

Section: Potential Use Of Amazonian Fruits In Metabolic Disordersmentioning

confidence: 99%

“…Finally, genotoxic stress is defined as the induction (e.g. by xenobiotics) of DNA damage and the response of the cell to that damage [87] [111]. The in vivo antimuta-genic effects found in açaí pulp, buriti oil and cubiu pulp encourage further studies [112] [113].…”

Section: Potential Use Of Amazonian Fruits In Metabolic Disordersmentioning

confidence: 99%

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Amazonian Fruits: An Overview of Nutrients, Calories and Use in Metabolic Disorders

Júnior¹,

Andrade²

2014

FNS

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Amazonian fruits are outstanding in quality. They are consumed as true delicacies of nature by the Brazilian population. Besides their attractive attributes, i.e. appearance, different textures and distinctive flavors, their nutritional value is diversified in the type of calories and the functional food ingredients. In addition to being very palatable, Amazonian fruits provide energy-rich macronutrients (lipids, proteins and carbohydrates), micronutrients (minerals, water-soluble vitamins and fat-soluble vitamins), prebiotics (dietary fibers, especially pectin), bioactive substances (carotenoids and polyphenols), variety in the diet and improvement in the organoleptic properties and digestibility of (mixed) foods. This study first aimed to review concepts applicable to nutritional constituents and caloric contents of Amazonian fruits. It also attempted to clarify the potential use of these fruits in metabolic disorders (i.e. diabetes mellitus and/or obesity). To fulfill these purposes, 12 fruits were chosen for their dietetic significance in the Brazilian Amazonia.

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The interrelationship of metabolic syndrome and neurodegenerative diseases with focus on brain-derived neurotrophic factor (BDNF): Kill two birds with one stone

2017

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The brain-derived neurotrophic factor (BDNF) is involved in metabolic syndrome (MetS) and neurodegenerative diseases (NDD) like Alzheimer's disease, Huntington's disease, Parkinson's disease and depression. If one factor plays an essential role in the pathogenesis of two diseases, it can be concluded that there might be a common root in these two diseases, as well. This review was aimed to highlight the crucial roles of BDNF in the pathogenesis of MetS and NDD and to introduce sole prophylactic or therapeutic applications, BDNF gene therapy and BDFN administration, in controlling MetS and NDD.

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Increased Risk for Obesity and Diabetes with Neurodegeneration in Developing Countries

Cited by 25 publications

References 148 publications

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

Amazonian Fruits: An Overview of Nutrients, Calories and Use in Metabolic Disorders

The interrelationship of metabolic syndrome and neurodegenerative diseases with focus on brain-derived neurotrophic factor (BDNF): Kill two birds with one stone

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