Increased serum diamine oxidase activity in nonallergic patients with migraine

García‐Martín, Elena; Navarro-Muñoz, Santiago; Amo, Gemma; Rodriguez, Christopher; Serrador, Mercedes; Alonso‐Navarro, Hortensia; Calleja, Marisol; Turpín-Fenoll, Laura; Recio-Bermejo, Marta; Garcia-Ruiz, Rafael; Millán-Pascual, Jorge; Navacerrada, Francisco; Plaza-Nieto, José Francisco; E, García-Albea; Agúndez, José A. G.; Jiménez‐Jiménez, Félix Javier

doi:10.1111/eci.13757

Cited by 11 publications

(12 citation statements)

References 24 publications

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“…In another study conducted in Spain with 197 patients with migraine and 245 healthy controls, AOC1 SNP rs10156191, which is linked to decreased DAO enzyme activity, was found to be associated with the risk of developing migraine, especially in women [ 23 ]. In a more recent study, serum DAO activity was found to be increased in patients with migraine, whereas the serum histamine levels were normal, and the polymorphisms were not associated with the risk for migraine as serum DAO activity was assessed [ 24 ]. Histamine has also been implicated in the pathogenesis of migraine.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Genetic Diamine Oxidase (DAO) Deficiency in Female Patients with Fibromyalgia in Spain

et al. 2023

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Diamine oxidase (DAO) is an enzyme that metabolizes intestinal histamine. Single nucleotide polymorphisms (SNPs) of the Amine Oxidase Copper Containing 1 (AOC1) gene can lead to low enzymatic activity or functionality in histamine metabolism. This study aimed to determine the prevalence of DAO deficiency for four variants of the AOC1 gene, p.Thr16Met (rs10156191), p.Ser332Phe (rs1049742), p.His664Asp (rs1049793), and c.691G > T (rs2052129), in 98 Spanish women with fibromyalgia between the ages of 33 and 60 years, and compare the distribution of allelic and genotypic frequencies with those of European population samples in Hardy–Weinberg equilibrium extracted from the Allele Frequency Aggregator (ALFA) database. The patients’ DNA was extracted, and analyzed using SNPE Multiplex (Single Nucleotide Primer Extension). The prevalence of genetic DAO deficiency was 74.5% based on the four variants of the AOC1 gene. SNP deficits were found at frequencies of 53.1% for p.Thr16Met, 49% for c.691G > T, 48% for p.His664Asp, and 19.4% for p.Ser332Phe. The allele and genotypic frequencies of the women with fibromyalgia did not differ from the European population. Variants of the AOC1 gene that are associated with genetic DAO deficiency could serve as a disruptive biomarker in patients with fibromyalgia. This study was registered in ClinicalTrials.gov Identifier: NCT05389761.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Genetic Diamine Oxidase (DAO) Deficiency in Female Patients with Fibromyalgia in Spain

et al. 2023

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“… Finding of microglial and parameningeal inflammatory activity in MWA, but not in MWoA, in neuroimaging studies [ 21 ]. Clinical–epidemiological, biochemical, experimental, and pharmacological data give support to the hypothesis of a possible contribution of histamine and mast cells in the etiopathogenesis or the clinical presentation of migraine [ 22 , 23 , 24 , 25 , 26 , 27 ]. Description of alterations in some microRNAs (miRNAs, important regulators to control inflammation), mainly miR-590-5p in migraine patients and animal models of migraine [ 28 ].…”

Section: Discussionmentioning

confidence: 88%

“…Clinical–epidemiological, biochemical, experimental, and pharmacological data give support to the hypothesis of a possible contribution of histamine and mast cells in the etiopathogenesis or the clinical presentation of migraine [ 22 , 23 , 24 , 25 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 88%

Lack of Association between Common LAG3/CD4 Variants and Risk of Migraine

García‐Martín

Navarro-Muñoz²,

Ayuso

et al. 2023

IJMS

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Several papers have been published suggesting a probable role of inflammatory factors in the etiopathogenesis of migraine. In this study, we investigated the possible association between common variants in the LAG3/CD4 genes (both genes, which are closely related, encode proteins involved in inflammatory and autoimmune responses) in the risk of migraine in a cohort of Caucasian Spanish participants. For this purpose, the frequencies of CD4 rs1922452, CD4 rs951818, and LAG3 rs870849 genotypes and allelic variants, using a specific TaqMan-based qPCR assay, were assessed in 290 patients diagnosed with migraine and in 300 healthy controls. The relationship of these variables with several clinical features of migraine was also analyzed. The frequencies of the analyzed LAG3/CD4 genotypes did not differ significantly between the two study groups and were not related to the sex, age at onset of migraine, family history of migraine, presence or absence of aura, or the triggering effect of ethanol on migraine episodes. These results suggest a lack of association between common variants in the LAG3/CD4 genes and the risk of developing migraine in the Caucasian Spanish population.

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“…(García-Martín et al 2015). Though, in a more recent study, serum DAO activity was increased in patients with migraine, but serum histamine levels were normal, and the polymorphisms was not associated with the risk for migraine considering that was analyzed in serum DAO activity (García-Martín et al 2022). Also, histamine has been implicated in the pathogenesis of migraine: a study investigating the possible association between functional single nucleotide polymorphisms in the diamine oxidase gene in the chromosome 7q36.1 with the risk for migraine reported lack of association between Thr105Ile SNP (rs1801105) polymorphism in the HNMT gene located at chromosome 2q22.1 (García-Martín et al 2007).…”

Section: Discussionmentioning

confidence: 93%

Prevalence of genetic diamine oxidase (DAO) deficiency in women with fibromyalgia in Spain

Okutan¹,

Casares

Perucho

et al. 2022

Preprint

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Diamine oxidase (DAO) is the enzyme responsible for the metabolism of intestinal histamine. Single nucleotide polymorphisms (SNPs) of the AOC1 gene are associated with low enzymatic activity or functionality in the metabolism of histamine. The objectives of the present study were to determine the prevalence of DAO deficiency for four variants of the AOC1 gene, p.Thr16Met (rs10156191), p.Ser332Phe (rs1049742), p.His664Asp (rs1049793) and c.691G > T (rs2052129) in Spanish women with fibromyalgia, as well as to compare the distribution of allelic and genotypic frequencies with European population samples in Hardy-Weinberg equilibrium (HWE) extracted from the ALFA (Allele Frequency Aggregator) database. The sample consisted of 98 Spanish women with fibromyalgia between 33 and 60 years old (48.5 years ± 7.5) DAO enzyme activity was determined by a sample of oral mucosa and a standard hygiene protocol was followed. The patients' DNA was extracted and the analysis of gene variants of interest was performed using SNPE Multiplex (Single Nucleotide Primer Extension). The prevalence of genetic DAO deficiency was 74.5% by the four variants of the AOC1 gene. The deficit for each SNP followed the following frequencies: p.Thr16Met (53.1%), c.691G > T (49%), p.His664Asp (48%) and p.Ser332Phe (19.4%). The allelic and genotypic prevalence of the variants had similar distributions of European population except for p.Ser332Phe. Variants of the AOC1 gene could be associated with genetic DAO deficiency and potential disruptive biomarker in fibromyalgia patients.

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Increased serum diamine oxidase activity in nonallergic patients with migraine

Cited by 11 publications

References 24 publications

Prevalence of Genetic Diamine Oxidase (DAO) Deficiency in Female Patients with Fibromyalgia in Spain

Prevalence of Genetic Diamine Oxidase (DAO) Deficiency in Female Patients with Fibromyalgia in Spain

Lack of Association between Common LAG3/CD4 Variants and Risk of Migraine

Prevalence of genetic diamine oxidase (DAO) deficiency in women with fibromyalgia in Spain

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