Increased serum fibroblast growth factor 21 levels are associated with adverse clinical outcomes after intracerebral hemorrhage

Chen, Keyang; Huang, Wenting; Wang, Jing; Xu, Huiqin; Ruan, Lixin; Li, Yongang; Wang, Zhen; Wang, Xue; Lin, Li; Li, Xiaokun

doi:10.3389/fnins.2023.1117057

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…FGF21 functions as the mitokine that transmits stress signals for non-autonomous response. A clinical report determined serum FGF21 is the prognosis biomarker of ICH [ 131 ], suggesting its key role in hemorrhagic stroke. FGF21 has found to suppress the production of NF-κB-related cytokines during hemorrhagic disease.…”

Section: Cross-talk Between Mitochondrial Stress and Neuroinflammatio...mentioning

confidence: 99%

Mitochondrial stress: a key role of neuroinflammation in stroke

Gao,

Peng,

Wang

et al. 2024

J Neuroinflammation

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Stroke is a clinical syndrome characterized by an acute, focal neurological deficit, primarily caused by the occlusion or rupture of cerebral blood vessels. In stroke, neuroinflammation emerges as a pivotal event contributing to neuronal cell death. The occurrence and progression of neuroinflammation entail intricate processes, prominently featuring mitochondrial dysfunction and adaptive responses. Mitochondria, a double membrane-bound organelle are recognized as the “energy workshop” of the body. Brain is particularly vulnerable to mitochondrial disturbances due to its high energy demands from mitochondria-related energy production. The interplay between mitochondria and neuroinflammation plays a significant role in the pathogenesis of stroke. The biological and pathological consequences resulting from mitochondrial stress have substantial implications for cerebral function. Mitochondrial stress serves as an adaptive mechanism aimed at mitigating the stress induced by the import of misfolded proteins, which occurs in response to stroke. This adaptive response involves a reduction in misfolded protein accumulation and overall protein synthesis. The influence of mitochondrial stress on the pathological state of stroke is underscored by its capacity to interact with neuroinflammation. The impact of mitochondrial stress on neuroinflammation varies according to its severity. Moderate mitochondrial stress can bolster cellular adaptive defenses, enabling cells to better withstand detrimental stressors. In contrast, sustained and excessive mitochondrial stress detrimentally affects cellular and tissue integrity. The relationship between neuroinflammation and mitochondrial stress depends on the degree of mitochondrial stress present. Understanding its role in stroke pathogenesis is instrumental in excavating the novel treatment of stroke. This review aims to provide the evaluation of the cross-talk between mitochondrial stress and neuroinflammation within the context of stroke. We aim to reveal how mitochondrial stress affects neuroinflammation environment in stroke.

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Section: Cross-talk Between Mitochondrial Stress and Neuroinflammatio...mentioning

confidence: 99%

Mitochondrial stress: a key role of neuroinflammation in stroke

Gao,

Peng,

Wang

et al. 2024

J Neuroinflammation

View full text Add to dashboard Cite

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Mediation Analysis of Serum Fibroblast Growth Factor 20 and Poor Prognosis After Ischemic Stroke

Chen,

Huang,

et al. 2024

JAHA

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Background We aimed to examine the relationship between serum FGF20 (fibroblast growth factor 20) levels and stroke prognosis in a multicenter cohort study. Methods and Results Patients with ischemic stroke/transient ischemic attack were prospectively recruited from 5 participating centers and followed up at 3 months and 1 year. FGF20 levels were measured using the ELISA method. The primary outcome was poor stroke functional outcome (modified Rankin Scale score of 3–6), and secondary outcomes included death and composite vascular events. Multivariable logistic regression analysis or Cox proportional hazards regression analysis was employed to estimate the relationship between FGF20 and study outcomes. Mediation analysis was conducted to examine the mediating effects of traditional risk factors on the association between FGF20 and stroke outcomes. A total of 1011 patients with ischemic stroke were included in the study. After adjusting for potential confounding factors, an elevated serum FGF20 level was associated with a reduced risk of the poor outcome and death. Multivariable adjusted spline regression analysis demonstrated a linear correlation between serum FGF20 levels and the stroke outcomes. The incorporation of FGF20 alongside conventional risk factors marginally enhanced the reclassification of adverse outcomes. Renal function and white blood cell count partially mediated the relationship between FGF20 and the prognosis of ischemic stroke. Conclusions Elevated FGF20 level is associated with decreased risks of adverse outcomes after ischemic stroke, which was partially mediated by renal function and white blood cells with a modest amount, indicating that serum FGF20 might serve as a promising biomarker for predicting stroke prognosis. Registration URL: https://www.chictr.org.cn ; Unique identifier: ChiCTR2100051104.

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Increased serum fibroblast growth factor 21 levels are associated with adverse clinical outcomes after intracerebral hemorrhage

Cited by 2 publications

References 34 publications

Mitochondrial stress: a key role of neuroinflammation in stroke

Mitochondrial stress: a key role of neuroinflammation in stroke

Mediation Analysis of Serum Fibroblast Growth Factor 20 and Poor Prognosis After Ischemic Stroke

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