Increased serum methylmalonic acid levels were associated with the presence of cardiovascular diseases

Wang, Xiaoya; Li, Wudi; Xiang, Meixiang

doi:10.3389/fcvm.2022.966543

Cited by 7 publications

(1 citation statement)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several metabolite markers have been associated with risk of CVD, including one-carbon metabolites such as total homocysteine (tHcy) (1) , methylmalonic acid (MMA) (2)(3)(4) , dimethylglycine (DMG) (5)(6)(7) , cystathionine (8)(9)(10) and choline (7,(11)(12)(13)(14) . One-carbon metabolism comprises all metabolic reactions involving the transfer of one-carbon units and includes the methionine-homocysteine cycle, the transsulfuration pathway, the folate cycle and the choline oxidation pathway (Fig.…”

mentioning

confidence: 99%

Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris

Bråtveit,

Van Parys,

Olsen

et al. 2024

Br J Nutr

View full text Add to dashboard Cite

Elevated plasma concentrations of several one-carbon metabolites are associated with increased CVD risk. Both diet-induced regulation and dietary content of one-carbon metabolites can influence circulating concentrations of these markers. We cross-sectionally analyzed 1928 patients with suspected stable angina pectoris (geometric mean age 61), representing elevated CVD risk, to assess associations between dietary macronutrient composition (food frequency questionnaire) and plasma one-carbon metabolites and related B-vitamin status markers (GC-MS/MS, LC-MS/MS, or microbiological assay). Diet-metabolite associations were modelled on the continuous scale, adjusted for age, sex, BMI, smoking, alcohol, and total energy intake. Average (geometric mean [95% prediction interval]) intake was 49 (38, 63) energy percent (E%) from carbohydrate, 31 (22, 45) E% from fat, and 17 (12, 22) E% from protein. The strongest associations were seen for higher protein intake, i.e., with higher plasma pyridoxal 5’-phosphate (PLP) (% change [95% confidence interval] 3.1 [2.1, 4.1]), cobalamin (2.9 [2.1, 3.7]), riboflavin (2.4 [1.1, 3.7]), and folate (2.1 [1.2, 3.1]), and lower total homocysteine (tHcy) (-1.4 [-1.9, -0.9]) and methylmalonic acid (MMA) (-1.4 [-2.0, -0.8]). Substitution analyses replacing mono- or polyunsaturated with saturated fatty acids demonstrated higher plasma concentrations of riboflavin (5.0 [0.9, 9.3] and 3.3 [1.1, 5.6]), tHcy (2.3 [0.7, 3.8] and 1.3 [0.5, 2.2]), and MMA (2.0 [0.2, 3.9] and 1.7 [0.7, 2.7]), and lower PLP (-2.5 [-5.3, 0.3] and -2.7 [-4.2, -1.2]). In conclusion, a higher protein intake, and replacing saturated with mono- and polyunsaturated fatty acids, was associated with a more favourable metabolic phenotype regarding metabolites associated with CVD risk.

show abstract

mentioning

confidence: 99%

Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris

Bråtveit,

Van Parys,

Olsen

et al. 2024

Br J Nutr

View full text Add to dashboard Cite

show abstract

Assessing and Monitoring Nutrition Security in the United States: A Narrative Review of Current Measures and Instruments

Kenney,

Adebiyi,

Seligman

et al. 2024

Curr Nutr Rep

View full text Add to dashboard Cite

Purpose of Review Because nutrition plays a crucial role in the development of chronic diseases, ensuring nutrition security is important for promoting population health. Nutrition security is defined as having consistent and equitable access to healthy, safe, affordable foods essential to optimal health and well-being. Distinguished from food security, nutrition security consists of two constructs: healthy diets and nutritional status. The study aimed to identify population measures that reflect the important constructs of nutrition security (i.e., healthy diets and nutritional status) to inform U.S. nutrition security assessment and monitoring. Recent Findings Through a narrative review conducted across multiple databases, associations between subconstructs of healthy diets and nutritional status were identified. Of the six subconstructs that constitute healthy diets, nutrient adequacy and moderation were most often used to assess and monitor healthfulness of U.S. population diets and were associated with health outcomes. There is little evidence of an association between health outcomes and macronutrient balance or diversity in the U.S. Thirteen instruments were identified as potentially suitable for measuring at least one subconstruct of healthy diet in the population. Summary This review highlights the importance of nutrition security in addressing population health challenges. It emphasizes the potential use of multiple instruments and measures to comprehensively monitor population nutrition security and inform intervention strategies. Identifying feasible and practical measures for assessing and monitoring nutrition security is imperative for advancing population health and mitigating the burden of chronic diseases.

show abstract

Increased serum methylmalonic acid levels were associated with the presence of cognitive dysfunction in older chronic kidney disease patients with albuminuria

Zhang,

Wu,

Wang

et al. 2024

BMC Geriatr

View full text Add to dashboard Cite

Background This study aimed to evaluate the correlation between serum methylmalonic acid (MMA) levels and cognition function in patients with chronic kidney disease (CKD). Methods In this cross-sectional study, we included 537 CKD individuals aged ≥ 60-year-old with albuminuria from the National Health and Nutrition Examination Survey (NHANES) 2011–2014. Four cognitive tests including the Digit Symbol Substitution Test (DSST), the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) Delayed Recall and Word Learning tests, and the Animal Fluency test (AF) were performed. Associations between MMA and cognition scores were assessed with linear regression models. Results MMA level was negatively associated with residual renal function and nutrition status. After multivariate adjustment, elevated serum MMA levels were independently correlated with decline of cognition in CKD patients with albuminuria. Conclusion Our study showed that higher serum MMA levels were independently associated with the presence of cognition dysfunction in CKD patients. The exact pathogenesis of MMA and cognition needs further research.

show abstract

Increased serum methylmalonic acid levels were associated with the presence of cardiovascular diseases

Cited by 7 publications

References 43 publications

Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris

Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris

Assessing and Monitoring Nutrition Security in the United States: A Narrative Review of Current Measures and Instruments

Increased serum methylmalonic acid levels were associated with the presence of cognitive dysfunction in older chronic kidney disease patients with albuminuria

Contact Info

Product

Resources

About