Increased serum resistin levels correlate with psoriasis: a meta-analysis

Abstract

BackgroundRecent studies implicate adipokines in the pathogenesis of inflammatory diseases, including psoriasis. In this study we evaluated the significance of serum resistin levels in psoriasis patients using a meta-analysis approach.223MethodsRelevant articles were retrieved by searching the following English and Chinese databases: Cochrane Library, PubMed, Springer Link, Chinese Biomedical Database (CBM) and Chinese National Knowledge Infrastructure (CNKI). The retrieved studies were subjected to a thorough screening procedure to identify case–control studies that contained the required data. Data was extracted from each study and Version 12.0 STATA statistical software was employed for statistical analyses.ResultsNine case–control studies, containing 421 psoriasis patients and 348 healthy controls, were included in this study. The major result of the meta-analysis revealed a statistically significant association between serum resistin levels and psoriasis (SMD = 2.22, 95%CI: 1.14-3.29, P < 0.001). Subgroup analysis based on ethnicity showed that, compared to the healthy controls, serum resistin levels were markedly higher in psoriasis patients in both Asian and Caucasian populations (Asians: SMD = 3.27, 95%CI = 1.62 ~ 4.91, P < 0.001; Caucasians: SMD = 0.91, 95%CI = 0.28 ~ 1.54, P < 0.001).ConclusionsBased on our results, we conclude that serum resistin level in psoriasis patients is higher than healthy controls, and raises the possibility that elevated serum resistin levels may be a novel diagnostic marker in psoriasis and may predict the occurrence of co-morbidities in psoriasis patients.

Serum Leptin, Resistin, and Adiponectin Concentrations in Psoriasis: A Meta-Analysis of Observational Studies

“…Our study confirms the results of other meta-analyses that have been previously performed on the same topic [9][10][11]. Nevertheless, the novelty of the present metaanalysis consists of (i) inclusion of all 3 types of adipokines together, providing the most complete and comprehensive aspect of this key issue and (ii) analysis of more than double the number of studies compared to previous meta-analyses, making it an updated review in the field.…”

“…Recent studies suggest that adipokines, such as leptin, resistin, and adiponectin, may be implicated in the pathogenesis of psoriasis [9][10][11]. Both leptin and resistin are known to promote the production of proinflammatory mediators involved in the pathogenesis of psoriasis, such as TNF-α and CXCL8 [12].…”

Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity

“…Conversely, in another study, both serum adiponectin and leptin levels were significantly decreased in psoriatic patients in comparison with the control group [58]. Other reports detected significantly lower levels of adiponectin and visfatin, and significantly higher levels of vaspin, omentin, chemerin, and resistin in psoriatic patients as compared to the control group [42, [59][60][61][62]. Of note, a meta-analysis including nine case-control studies, containing 421 psoriasis patients and 348 healthy controls, revealed a statistically significant association between serum resistin levels and psoriasis [59].…”

“…Other reports detected significantly lower levels of adiponectin and visfatin, and significantly higher levels of vaspin, omentin, chemerin, and resistin in psoriatic patients as compared to the control group [42, [59][60][61][62]. Of note, a meta-analysis including nine case-control studies, containing 421 psoriasis patients and 348 healthy controls, revealed a statistically significant association between serum resistin levels and psoriasis [59]. Interestingly, successful treatment of psoriasis with biologicals (i.e., infliximab and ustekinumab) or phototherapy (narrow band-UVB) was related to an increase of adiponectin serum levels and a decrease of leptin and resistin serum concentration [60].…”

Evaluation of Serum Resistin Levels and Metabolic Syndrome Related Parameters in Chronic Spontaneous Urticaria

“…Many studies reported that resistin was associated with insulin resistance, hyperglycemia and obesity (9)(10)(11). In addition, resistin was shown to be related with inflammation and immunity in many disorders including atherosclerosis, renal disorders, respiratory system disorders and psoriasis (11,12).…”