Increased soluble CD4 and decreased soluble CD8 molecules in patients with Sjögren's syndrome

Sawada, Shigemasa; Sugai, Susumu; Iijima, Sumio; Takei, Masami; Paredes, Ernesto; Hayama, Takashi; Nishinarita, Susumu; Hosokawa, Yoshifumi; Horie, Takashi; Obara, Takashi

doi:10.1016/0002-9343(92)90103-i

Cited by 30 publications

(18 citation statements)

References 31 publications

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“…No discernible changes in those levels were found before the relapses. This is in contrast to recent findings in Sjogren's syndrome, SLE, scleroderma and rheumatoid arthritis [27][28][29][30]. Both in primary Sjogren's syndrome and active rheumatoid arthritis, elevated levels of sCD4 with concurrent decreased levels of sCD8 have been reported [27.29,30].…”

Section: Discussioncontrasting

confidence: 54%

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Serum markers of T cell activation in relapses of Wegener's granulomatosis

Stegeman¹,

Tervaert²,

Huitema³

et al. 1993

Clinical and Experimental Immunology

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SUMMARYLevels of soluble IL-2 receptor (sIL-2R). soluble CD4 {sCD4) and CD8 (sCD8) were measured by sandwich ELISA as markers for T cell activation in serial serum samples from 16 patients showing 18 histologicaliy proven relapses of Wegener's granulomatosis (WG). Levels of sIL-2R increased from 1065 U/ml (median, range 373-2345 U/ml)6monthsbefore the relapse to 1684 U/ml (median, range 486-3404 U/ml) at the moment of relapse for the whole group (P^OIO). The eight major relapses showed a profound rise in s!L-2R levels, from 1008 U/ml (median, range 686-1553 U/ml) 6 months before the relapse, to 1994 U/ml (median, range 1469-3404 U/ml) at the moment of relapse (/»< 0 01), The levels of sIL-2R at the moment of relapse were significantly higher at the eight major relapses than at the time of the 10 minor relapses (/'<0 05). Minor relapses were not accompanied by a significant rise in slL-2R levels. Titresofantineutrophilcytoplasmic antibodies (ANCA) rose by two or more titresteps or from negative to positive in 15/18 patients during the 6 months period before the relapse. In all seven cases with both a rise of the ANCA titreand an at least 15"At Increase in sIL-2R levels, the rise in ANCA preceded the rise in sIL-2R by at least 1 month, The level of slL-2R at the moment of relapse correlated with the level of C-reactive protein (r = 0 488. /'<0 ()5) and with the disease activity score (r=^0 824, P<0002). There were no significant changes in levels of sCD4 or sCDB. although the levels of sCD4 tended to be higher at the time of major relapses. We conclude that major relapses of Wegener's granulomatosis are accompanied by systemic T cell activation, T cell activation, however, does not appear to precede the rise in ANCA titre.

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Section: Discussioncontrasting

confidence: 54%

“…Also, correlations between disease activity and levels of sIL-2R have been reported in some of these diseases [ 16,18.24-26]. Levels of soluble CD4 (sCD4) and CDS (sCD8) antigen in serum have also been reported to reflect T cell activation in several different clinical autoimmune conditions [27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Serum markers of T cell activation in relapses of Wegener's granulomatosis

Stegeman¹,

Tervaert²,

Huitema³

et al. 1993

Clinical and Experimental Immunology

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“…A lack of such correlation has also been reported previously between the number of CD8 positive T lymphocytes and the sCD8 concentration in human immune deficiency virus infected populations (26). Moreover, we found no significant correlation in patients with Sjogren's syndrome (18). There are many reports of increased sCD8 molecules in HIV infected populations (27)(28)(29).…”

Section: Esr (Rnm/hr)supporting

confidence: 61%

Immunologic significance of increased soluble CD8/CD4 molecules in patients with active systemic lupus erythematosus

Sawada

Hashimoto

Iijima

et al. 1993

Clinical Laboratory Analysis

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This study attempted to estimate soluble CD4(sCD4)/CD8(sCD8) molecules in active systemic lupus erythematosus (SLE) patients. Measurements were made by solid-phase enzyme-linked immunosorbent assay. sCD8 or sCD4 molecules were significantly increased in the patients as compared to control subjects. sCD8 correlated with the erythrocyte sedimentation rate. sCD4 correlated with the anti DNA antibody titer, the IgG concentration, and negatively with the complement titer. An association of these molecules with immunologic abnormalities and disease activity exists in SLE patients.

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“…Soluble CDX levels eorrelate with the percentage of CD8''"''" HLA-DR ' cells, which suggests a useful ri)lcforsCD8 in monitoring the CD8'"'^'" iymphoeyte activation [20]. Levels of sCDS have been reported higher in SLE than in Sjogren's syndrome or normal eontrols [19]. Both findings are consistent with T lymphoeyte aetivation during clinically quiescent SLE.…”

Section: Discussionmentioning

confidence: 84%

“…Sawada el al. found level.s of sCD4 to be higher in patients with inactive SLE than in normal eontrols, although levels were lower than in SJogren's syndrome [19]. Soluble CDX levels eorrelate with the percentage of CD8''"''" HLA-DR ' cells, which suggests a useful ri)lcforsCD8 in monitoring the CD8'"'^'" iymphoeyte activation [20].…”

Section: Discussionmentioning

confidence: 99%

B cell activation in clinically quiescent systemic lupus erythematosus (SLE) is related to immunoglobulin levels, but not to levels of anti-dsDNA, nor to concurrent T cell activation

Spronk¹,

Gun²,

Limburg³

et al. 1993

Clinical and Experimental Immunology

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SUMMARY In clinically quiescent SLE hypergammaglobulinaemia, presence of autoantibodies, and increased soluble IL‐2 receptors (sIL‐2R) have been reported, suggesting persistent B as well as T cell activation. In contrast, the primary immune response lo test antigens is markedly decreased. To analyse these phenomena at a cellular level, we undertook a cross‐sectional study on 13 non‐active SLE patients and 15 controls. We determined the composition of lymphocyte subsets with special attention to activation markers (CD25, HLA‐DR, CD38) and the presence of naive T cells (CD45RO‐), and related those findings to serological parameters. In non‐active SLE patients the expression of activation markers on B cells and T cells was higher than in normal controls (P≤ 0·02), but was not interrelated. Percentages of activated B cells in SLB were related lo levels of total IgG (P < 0·02)and IgM (P < 0·02) but not to anti‐dsDNA, suggesting a disordered immune system also in clinically quiescent SLE. Numbers of CD4+ cells (P < 0·001) and CD4+CD45RO‐ cells (P < 0·05) were decreased. The latter finding might explain the anergy to primary test antigens in clinically quiescent SLE.

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Increased soluble CD4 and decreased soluble CD8 molecules in patients with Sjögren's syndrome

Cited by 30 publications

References 31 publications

Serum markers of T cell activation in relapses of Wegener's granulomatosis

Serum markers of T cell activation in relapses of Wegener's granulomatosis

Immunologic significance of increased soluble CD8/CD4 molecules in patients with active systemic lupus erythematosus

B cell activation in clinically quiescent systemic lupus erythematosus (SLE) is related to immunoglobulin levels, but not to levels of anti-dsDNA, nor to concurrent T cell activation

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