Increased subcortical region volume induced by electroconvulsive therapy in patients with schizophrenia

Shan, Xiaoxiao; Zhang, Haisan; Dong, Zhao; Chen, Jindong; Liu, Feng; Zhao, Jingping; Zhang, Hongxing; Guo, Wenbin

doi:10.1007/s00406-021-01303-6

Cited by 7 publications

(5 citation statements)

References 59 publications

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“…Similarly, structural abnormalities in the left amygdala were found to be significantly associated with PANSS negative symptoms ( 68 ), which is consistent with studies that found a negative correlation between the volume of the hippocampus-amygdala complex and clinical ratings of negative symptoms and thought disturbances ( 69 , 70 ). Nevertheless, the increased GMV in the amygdala and its negative correlation with PANSS scores have also been reported ( 71 ). Considering the function of the amygdala in regulating emotional and motivational behavior ( 72 ), it is reasonable that there is an association between the amygdala and negative symptoms of reduced expression in schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation

et al. 2022

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BackgroundPersistent negative symptoms (PNS) include both primary and secondary negative symptoms that persist after adequate treatment, and represent an unmet therapeutic need. Published magnetic resonance imaging (MRI) evidence of structural and resting-state functional brain abnormalities in schizophrenia with PNS has been inconsistent. Thus, the purpose of this meta-analysis is to identify abnormalities in structural and functional brain regions in patients with PNS compared to healthy controls.MethodsWe systematically searched PubMed, Web of Science, and Embase for structural and functional imaging studies based on five research methods, including voxel-based morphometry (VBM), diffusion tensor imaging (DTI), functional connectivity (FC), the amplitude of low-frequency fluctuation or fractional amplitude of low-frequency fluctuation (ALFF/fALFF), and regional homogeneity (ReHo). Afterward, we conducted a coordinate-based meta-analysis by using the activation likelihood estimation algorithm.ResultsTwenty-five structural MRI studies and thirty-two functional MRI studies were included in the meta-analyses. Our analysis revealed the presence of structural alterations in patients with PNS in some brain regions including the bilateral insula, medial frontal gyrus, anterior cingulate gyrus, left amygdala, superior temporal gyrus, inferior frontal gyrus, cingulate gyrus and middle temporal gyrus, as well as functional differences in some brain regions including the bilateral precuneus, thalamus, left lentiform nucleus, posterior cingulate gyrus, medial frontal gyrus, and superior frontal gyrus.ConclusionOur study suggests that structural brain abnormalities are consistently located in the prefrontal, temporal, limbic and subcortical regions, and functional alterations are concentrated in the thalamo-cortical circuits and the default mode network (DMN). This study provides new insights for targeted treatment and intervention to delay further progression of negative symptoms.Systematic review registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42022338669].

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Section: Discussionmentioning

confidence: 99%

Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation

et al. 2022

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“…( Ousdal et al, 2020 ) These volume increases correlated with the strength of the stimulating electric field but not with the therapeutic effect. ( Argyelan et al, ) Similar longitudinal imaging studies have been conducted in SCZ, ( Wolf et al, 2016 , Thomann et al, 2017 , Jiang et al, 2019 , Jiang et al, 2019 , Wang et al, 2019 , Shan et al, 2021 ) although fewer in number than in depression. These studies demonstrated volume increase in the hippocampus, amygdala, insula, and other regions.…”

Section: Introductionmentioning

confidence: 75%

Commonalities and differences in ECT-induced gray matter volume change between depression and schizophrenia

Kawashima

Yamasaki

Kubota

et al. 2023

NeuroImage: Clinical

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“…As reported in previous studies, the placement of ECT electrodes can influence the efficacy of treatment, as well as effects on brain structure ( 44 – 46 ). Specifically, gray matter volume increases were observed in the bilateral hippocampus and left MTG after 6 weeks of ECT combined with antipsychotic treatment in patients with SCZ ( 47 ). Similar findings were found in a observer-independent coordinate-based meta-analysis of a large sample of MDD.…”

Section: Discussionmentioning

confidence: 99%

Temporoparietal Connectivity Within Default Mode Network Associates With Clinical Improvements in Schizophrenia Following Modified Electroconvulsive Therapy

Huang

Jiang

et al. 2022

Front. Psychiatry

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Although modified electroconvulsive therapy (ECT) has been reported to be effective for the treatment of schizophrenia (SCZ), its action mechanism is unclear. To elucidate the underlying ECT mechanisms of SCZ, this study used a longitudinal cohort including 21 SCZ patients receiving only antipsychotics (DSZ group) and 21 SCZ patients receiving a regular course of ECT combining with antipsychotics (MSZ group) for 4 weeks. All patients underwent magnetic resonance imaging (MRI) scans at baseline (t1) and follow-up (t2) time points. A matched healthy control (HC) group included 23 individuals who were only scanned at baseline. Functional connectivity (FC) within the default mode network (DMN) was evaluated before and after ECT. Significant interaction of the group over time was found in FC between angular gyrus (AG) and middle temporal gyrus (MTG). Post-hoc analysis showed a significantly enhanced FC of left AG(AG.L) and right MTG (MTG.R) in the MSZ group relative to the DSZ group. In addition, the right AG (AG.R) showed significantly enhanced FC between MTG.R and left MTG (MTG.L) after ECT in the MSZ group, but no in the DSZ group. In particular, the FCs change in AG.L-MTG.R and AG.R-MTG.R were positively correlated with the Positive and Negative Syndrome Scale (PANSS) negative score reduction. Furthermore, the FC change in AG.L-MTG.R was also positively correlated with the PANSS general psychopathology score reduction. These findings confirmed a potential relationship between ECT inducing hyperconnectivity within DMN and improvements in symptomatology of SCZ, suggesting that ECT controls mental symptoms by regulating the temporoparietal connectivity within DMN.

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Increased subcortical region volume induced by electroconvulsive therapy in patients with schizophrenia

Cited by 7 publications

References 59 publications

Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation

Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation

Commonalities and differences in ECT-induced gray matter volume change between depression and schizophrenia

Temporoparietal Connectivity Within Default Mode Network Associates With Clinical Improvements in Schizophrenia Following Modified Electroconvulsive Therapy

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