Increased Systemic Immune-Inflammation Index Was Associated with Type 2 Diabetic Peripheral Neuropathy: A Cross-Sectional Study in the Chinese Population

Abstract

Background: Systemic immune-inflammation index (SII), a novel inflammatory marker, has been demonstrated to be associated with type 2 diabetes mellitus (T2DM) and its vascular complications, however, the relation between SII and diabetic peripheral neuropathy (DPN) has been never reported. We aimed to explore whether SII is associated with DPN in Chinese population. Methods: A cross-sectional study was conducted among 1460 hospitalized patients with T2DM. SII was calculated as the platelet count × neutrophil count/lymphocyte count, and its possible association with DPN was investigated by correlation and multivariate logistic regression analysis, and subgroup analyses. Results: Patients with higher SII quartiles had higher vibration perception threshold and prevalence of DPN (all P<0.01), and SII was independently positively associated with the prevalence of DPN (P<0.01). Multivariate logistic regression analysis showed that the risk of prevalence of DPN increased progressively across SII quartiles (P for trend <0.01), and participants in the highest quartile of SII was at a significantly increased risk of prevalent DPN compared to those in the lowest quartile after adjustment for potential confounding factors (odds rate: 1.211, 95% confidence intervals 1.045-1.404, P<0.05). Stratified analysis revealed positive associations of SII quartiles with risk of prevalent DPN only in men, people less than 65 years old, with body mass index <24 kg/m 2 , duration of diabetes >5 years, hypertension, dyslipidaemia, poor glycaemic control, and estimated glomerular filtration rate <90 mL/min/ 1.73 m 2 (P for trend <0.01 or P for trend <0.05). The receiver operating characteristic curve analysis revealed that the optimal cut-off point of SII for predicting DPN was 617.67 in patients with T2DM, with a sensitivity of 45.3% and a specificity of 73%. Conclusion:The present study showed that higher SII is independently associated with increased risk of DPN, and SII might serve as a new risk biomarker for DPN in Chinese population.

Investigation of Systemic Immune Inflammation (SII) Index as an Indicator of Morbidity and Mortality in Type 2 Diabetic Retinopathy Patients in a 4-Year Follow-up Period

“…In a study of 300 Type 2 DM patients on whether SII has a predictive value for diabetic nephropathy and cardiovascular diseases in patients with Type 2 DM, predictive SII values were found for cardiovascular diseases and diabetic nephropathy [28]. In a study investigating the relationship between SII and diabetic neuropathy in 1460 hospitalized type 2 DM patients in China, it was found that SII levels were significantly higher in patients with diabetic neuropathy [29]. In another study in which 584 patients with diabetic nephropathy (DN) due to Type 2 DM, Type 2 DM patients without DN, and a control group were investigated for the relationship between SII and DN, it was found that high SII levels were associated with DN [30].…”

Investigation of the Systemic Immune Inflammation (SII) Index as an Indicator of Morbidity and Mortality in Type 2 Diabetic Retinopathy Patients in a 4-Year Follow-Up Period

“…In a study of 300 type 2 DM patients on whether SII has a predictive value for diabetic nephropathy and cardiovascular diseases in patients with type 2 DM, predictive SII values were found for cardiovascular diseases and diabetic nephropathy [ 31 ]. In a study investigating the relationship between SII and diabetic neuropathy in 1460 hospitalized type 2 DM patients in China, it was found that SII levels were significantly higher in patients with diabetic neuropathy [ 32 ]. In another study in which 584 patients with diabetic nephropathy (DN) due to type 2 DM, type 2 DM patients without DN, and a control group were investigated for the relationship between SII and DN, it was found that high SII levels were associated with DN [ 33 ].…”