Increased T cell activation in BALF from children with <i>Mycoplasma pneumoniae</i> pneumonia

Guo, Li; Liu, Fang; Lu, Meiping; Zheng, Qi; Chen, Zhimin

doi:10.1002/ppul.23095

Cited by 63 publications

(50 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mycoplasma pneumoniae pneumonia has an increase of neutrophils and IL-6, especially in severe group. Compared to acute stage, a decreased percentage of neutrophils and IL-6 level was observed at the recovery stage in children with severe Mycoplasma pneumoniae pneumonia [155]. However, treatment with prednisolone or cyclosporin-A leads to marked neutrophils and exudates in the alveolar lumen.…”

Section: Neutrophils In Infectious Pneumoniamentioning

confidence: 99%

Advanced Role of Neutrophils in Common Respiratory Diseases

Liu

Pang

Wang

et al. 2017

Journal of Immunology Research

View full text Add to dashboard Cite

Respiratory diseases, always being a threat towards the health of people all over the world, are most tightly associated with immune system. Neutrophils serve as an important component of immune defense barrier linking innate and adaptive immunity. They participate in the clearance of exogenous pathogens and endogenous cell debris and play an essential role in the pathogenesis of many respiratory diseases. However, the pathological mechanism of neutrophils remains complex and obscure. The traditional roles of neutrophils in severe asthma, chronic obstructive pulmonary diseases (COPD), pneumonia, lung cancer, pulmonary fibrosis, bronchitis, and bronchiolitis had already been reviewed. With the development of scientific research, the involvement of neutrophils in respiratory diseases is being brought to light with emerging data on neutrophil subsets, trafficking, and cell death mechanism (e.g., NETosis, apoptosis) in diseases. We reviewed all these recent studies here to provide you with the latest advances about the role of neutrophils in respiratory diseases.

show abstract

Section: Neutrophils In Infectious Pneumoniamentioning

confidence: 99%

Advanced Role of Neutrophils in Common Respiratory Diseases

Liu

Pang

Wang

et al. 2017

Journal of Immunology Research

View full text Add to dashboard Cite

show abstract

“…It causes up to 40% of community-acquired pneumonia (CAP) cases in children and as much as 18% of cases requiring hospitalization; these percentages are even higher during epidemics 2–4. The incidence of Mycoplasma pneumoniae pneumonia (MPP) has been increasing in recent years.…”

Section: Introductionmentioning

confidence: 99%

Relationships between Th1/Th2 cytokine profiles and chest radiographic manifestations in childhood<em> Mycoplasma pneumoniae</em> pneumonia

Jiu-ling

Wang

2016

TCRM

View full text Add to dashboard Cite

BackgroundMycoplasma pneumoniae pneumonia (MPP) is one of the most common childhood community-acquired pneumonias, and the chest radiograph usually shows bronchial pneumonia, segmental/lobar pneumonia, or segmental/lobar pneumonia with pleural effusion. The imbalance of Th1/Th2 function after Mycoplasma pneumoniae infection is an important immunological mechanism of MPP. In this study, we aimed to evaluate the correlations between Th1/Th2 cytokine profiles and chest radiographic manifestations in MPP children.Patients and methodsA total of 87 children with MPP were retrospectively reviewed in this study. According to the chest radiographic manifestations, they were divided into the following three groups: bronchial MPP group, segmental/lobar MPP group, and segmental/lobar MPP with pleural effusion group. Clinical features and changes in Th1/Th2 cytokines were further analyzed.ResultsThe incidence of tachypnea and cyanosis was higher in children with segmental/lobar MPP with pleural effusion than in those with segmental/lobar or bronchial MPP. The peak body temperature of segmental/lobar MPP was higher than that of bronchial MPP, and the duration of fever and hospitalization was positively correlated with the severity of MPP. MPP children’s chest radiograph showed a relationship with the changes in Th1/Th2 cytokines. Serum interleukin-4, interleukin-10 (IL-10), interferon-γ, and tumor necrosis factor-α (TNF-α) of segmental/lobar MPP were significantly higher than those of bronchial MPP, and serum IL-10 (cutoff value: 27.25 pg/mL) can be used as a diagnostic predictor for segmental/lobar MPP. Serum TNF-α and interleukin-6 of segmental/lobar MPP with pleural effusion were significantly higher than those of segmental/lobar MPP without pleural effusion. Serum TNF-α (cutoff value: 60.25 pg/mL) can be used as a diagnostic predictor for segmental/lobar MPP with pleural effusion.ConclusionThere were significant correlations between Th1/Th2 cytokine profiles and chest radiographic manifestations in MPP children. Serum IL-10 and TNF-α can be used as an optimal predictor for segmental/lobar MPP and segmental/lobar MPP with pleural effusion, respectively.

show abstract

“…IL-6 was also associated with pleural effusion [20] and radiological appearance [8] in MPP patients. Guo L et al reported that IL-6s in serum of patients infected by the macrolide-resistant strains were higher than those infected by non macrolide-resistant strains [21] . Therefore IL-6 was closely related to MPP.…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of IL-6s and IL-27s in Bronchoalveolar lavage fluids from children with mycoplasma pneumoniae pneumonia

Zhao

Zhang³

2020

Preprint

View full text Add to dashboard Cite

Backgrounds: IL-6 is associated with the severity of mycoplasma pneumoniae pneumonia (MPP). But the relationship between IL-27 and MPP was unknown.Methods: 98 patients with MPP who were under 14 years old, were enrolled in this study and divided into mild cases and severe cases, Mycoplasma pneumoniae (MP) single infection group and MP mixed infection group, and low MP DNA loads group and high MP DNA loads group, by severity, infection types and DNA loads respectively. 15 children with foreign bodies for bronchus were also enrolled as control. IL-6s and IL-27s in bronchoalveolar lavage fluids (BALFs) from these children were measured by ELISA.Results: There were significant differences in IL-6s of BALFs from patients between mild cases and severe cases, MP single infection group and MP mixed infection group, and low MP DNA loads group and high MP DNA loads group, respectively (P 0.05). Compared with IL-6s of BALFs from control, IL-6 in BALFs from the 5 patient groups were significantly higher (P 0.05) except that from low MP DNA loads group. IL-27s in BALFs from MP mixed infection group were significantly lower than those from MP single infection group and control (P 0.05) respectively.Conclusion: IL-6 was firmly associated with MPP and had potential application in clinical practice while IL-27 was not related to MP infection. BackgroundMycoplasma pneumoniae (MP) is one of the main pathogens in respiratory infections in children. It causes more than 40% of community-acquired pneumonia (CAP) cases in children and 18% of these cases need hospitalization [1] . At present there have been many problems with patients suffering from Mycoplasma pneumoniae pneumonia (MPP) such as the increasing macrolide resistance rate [2] , the complex multiple systemic complications [3] , the increasing occurrence of refractory MPP [4] .Therefore, MPP has attracted great attentions from many researchers and patients. It is widely recognized that immune function disorders have been involved in the pathogenesis of MPP [5] . And IL-6 is an important cytokine which can regulate immune function [6] . It is involved in the infection process of MP and plays an important role in the pathogenesis of MPP [7] . One study suggested that

show abstract

Increased T cell activation in BALF from children with Mycoplasma pneumoniae pneumonia

Abstract: Increased activation of T cell in BALF may play an important role in the inflammatory response of acute and severe MPP. IL-6 may predict the severity and prognosis and provide a better assessment for patient care. However, the underlying mechanism awaits further detailed investigations.

Cited by 63 publications

References 32 publications

Advanced Role of Neutrophils in Common Respiratory Diseases

Advanced Role of Neutrophils in Common Respiratory Diseases

Relationships between Th1/Th2 cytokine profiles and chest radiographic manifestations in childhood<em> Mycoplasma pneumoniae</em> pneumonia

The clinical significance of IL-6s and IL-27s in Bronchoalveolar lavage fluids from children with mycoplasma pneumoniae pneumonia

Contact Info

Product

Resources

About