Increased Th22 cell numbers in a general pediatric population with filaggrin haploinsufficiency: The Generation R Study

Looman, Kirsten I M; Mierlo, Minke M.F. van; Zelm, Menno C. van; Hu, Chen; Duijts, Liesbeth; Jongste, Johan C. de; Nijsten, Tamar; Pardo, Luba M.; Jong, Jessica C. Kiefte-de; Moll, Henriëtte A.; Pasmans, Suzanne G M A

doi:10.1111/pai.13502

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…Moreover, gene predisposition influences the immune pathways in AD. AD children with FLG mutation demonstrated higher Th22 cell numbers without affecting the adaptive immunity composition ( 181 ).…”

Section: The Roles Of Th22 Cells In Skin Diseasesmentioning

confidence: 99%

The Role of T Helper 22 Cells in Dermatological Disorders

Pan

Wang

et al. 2022

Front. Immunol.

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T helper 22 (Th22) cells are a newly identified subset of CD4+ T cells that secrete the effector cytokine interleukin 22 (IL-22) upon specific antigen stimulation, barely with IFN-γ or IL-17. Increasing studies have demonstrated that Th22 cells and IL-22 play essential roles in skin barrier defense and skin disease pathogenesis since the IL-22 receptor is widely expressed in the skin, especially in keratinocytes. Herein, we reviewed the characterization, differentiation, and biological activities of Th22 cells and elucidated their roles in skin health and disease. We mainly focused on the intricate crosstalk between Th22 cells and keratinocytes and provided potential therapeutic strategies targeting the Th22/IL-22 signaling pathway.

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Section: The Roles Of Th22 Cells In Skin Diseasesmentioning

confidence: 99%

The Role of T Helper 22 Cells in Dermatological Disorders

Pan

Wang

et al. 2022

Front. Immunol.

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Modern approach to the treatment of atopic dermatitis with preserved fetal liver cells (experimental study)

Leonova¹,

Bondarovych²,

Ostankov³

et al. 2021

PUMTS

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One of the urgent problems of modern dermatology is atopic dermatitis (AD), which has multifactorial pathogenesis, the significant prevalence of the disease, the increased frequency of the complicated course, the lack of radical methods of therapy. The expediency to use cryopreserved fetal liver cells (cFLCs) for the treatment of AD is proved by a wide range of produced by them biologically active substances with immunomodulatory and anti-inflammatory activity. Disclosure of the mechanisms of the therapeutic action of biotherapeutic drugs in AD provides for the determination of the state of the cellular and humoral links of the immune system (IS). In this regard, the aim of the work was to assess the effectiveness of cFLCs injection by characteristic clinical and immunological parameters in rats with AD. The results of the study in rats with AD revealed disorders in the IS, manifested in a decrease in the total number of T-lymphocytes and their subpopulations in the spleen, in an increase in the level of circulating immune complexes and a number of immunoglobulins in the blood serum, and in a decrease in the phagocytic activity of the peritoneal cavity cells. Therapy with cFLCs, in contrast to the standard treatment with prednisolone, significantly improves the therapeutic effect, which is demonstrated by the restoration of the parameters of the cellular and humoral links of the immune system in animals with AD. The amplifying effect of the combined use of cFLCs and prednisolone on a number of parameters of the immune system in AD was shown.

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Increased Th22 cell numbers in a general pediatric population with filaggrin haploinsufficiency: The Generation R Study

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 2 publications

References 35 publications

The Role of T Helper 22 Cells in Dermatological Disorders

The Role of T Helper 22 Cells in Dermatological Disorders

Modern approach to the treatment of atopic dermatitis with preserved fetal liver cells (experimental study)

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