Increased Tissue Transglutaminase Levels Are Associated With Increased Epileptiform Activity in Electroencephalography Among Patients With Celiac Disease

Işıkay, Sedat; Hızlı, Şamil; Çoşkun, Serkan; Yılmaz, Kutluhan

doi:10.1590/s0004-28032015000400005

Cited by 10 publications

(11 citation statements)

References 27 publications

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“…The concept that the occipital region is frequently involved in CD seems to be supported by the evidence of occipital calcium deposition, occipital lobe semiology, and EEG findings. The preferential involvement of this lobe may lie on several factors, such as its vulnerability to some metabolic circumstances (e.g., hypoglycemia and hypoxia) and its thinner morphological structure than other cortical regions (Işıkay et al, 2015b ). However, the opposite scenario (the occurrence of CD in patients with “posterior” epileptic semiology) is not always true because in a group of 90 pediatric epileptic patients with occipital EEG abnormalities, tTG antibody was positive in only two (Canales et al, 2006 ).…”

Section: Neurophysiological Techniques Used To Probe Cns Involvement mentioning

confidence: 99%

Neurophysiology of the “Celiac Brain”: Disentangling Gut-Brain Connections

et al. 2017

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Celiac disease (CD) can be considered a complex multi-organ disorder with highly variable extra-intestinal, including neurological, involvement. Cerebellar ataxia, peripheral neuropathy, seizures, headache, cognitive impairment, and neuropsychiatric diseases are complications frequently reported. These manifestations may be present at the onset of the typical disease or become clinically evident during its course. However, CD subjects with subclinical neurological involvement have also been described, as well as patients with clear central and/or peripheral nervous system and intestinal histopathological disease features in the absence of typical CD manifestations. Based on these considerations, a sensitive and specific diagnostic method that is able to detect early disease process, progression, and complications is desirable. In this context, neurophysiological techniques play a crucial role in the non-invasive assessment of central nervous system (CNS) excitability and conductivity. Moreover, some of these tools are known for their valuable role in early diagnosis and follow-up of several neurological diseases or systemic disorders, such as CD with nervous system involvement, even at the subclinical level. This review provides an up-to-date summary of the neurophysiological basis of CD using electroencephalography (EEG), multimodal evoked potentials, and transcranial magnetic stimulation (TMS). The evidence examined here seems to converge on an overall profile of “hyperexcitable celiac brain,” which partially recovers after institution of a gluten-free diet (GFD). The main translational correlate is that in case of subclinical neurological involvement or overt unexplained symptoms, neurophysiology could contribute to the diagnosis, assessment, and monitoring of a potentially underlying CD.

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Section: Neurophysiological Techniques Used To Probe Cns Involvement mentioning

confidence: 99%

Neurophysiology of the “Celiac Brain”: Disentangling Gut-Brain Connections

et al. 2017

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“…The involvement of this region may depend on different reasons, including its susceptibility to some metabolic factors (e.g., hypoxia, hypoglycemia, etc.) and its structure, which is morphologically thinner than other cortices ( Işikay et al, 2015 ). The predilection for the posterior circulation may also explain the fact that cerebellar dysfunction is by far the commonest neurological manifestation of CD.…”

Section: Discussionmentioning

confidence: 99%

Cerebral hemodynamic changes to transcranial Doppler sonography in celiac disease: A pilot study

Fisicaro¹,

Lanza²,

D’Agate³

et al. 2022

Front. Hum. Neurosci.

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BackgroundSonographic mesenteric pattern in celiac disease (CD) suggests a hyperdynamic circulation. Despite the well-known CD-related neurological involvement, no study has systematically explored the cerebral hemodynamics to transcranial Doppler sonography.Materials and methodsMontreal Cognitive Assessment (MoCA) and 17-item Hamilton Depression Rating Scale (HDRS) were assessed in 15 newly diagnosed subjects with CD and 15 age-, sex-, and education-matched healthy controls. Cerebral blood flow (CBF) velocities and indices of resistivity (RI) and pulsatility (PI) from the middle cerebral artery (MCA), bilaterally, and the basilar artery (BA) were recorded. We also assessed cerebral vasomotor reactivity (CVR) through the breath-holding test (BHT).ResultsWorse scores of MoCA and HDRS were found in patients compared to controls. Although patients showed higher values of CBF velocity from MCA bilaterally compared to controls, both at rest and after BHT, no comparison reached a statistical significance, whereas after BHT both RI and PI from BA were significantly higher in patients. A significant negative correlation between both indices from BA and MoCA score were also noted.ConclusionThese treatment-naïve CD patients may show some subtle CVR changes in posterior circulation, thus possibly expanding the spectrum of pathomechanisms underlying neuroceliac disease and in particular gluten ataxia. Subclinical identification of cerebrovascular pathology in CD may help adequate prevention and early management of neurological involvement.

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“…A Doença Celíaca (DC) é uma enteropatia de afecção crônica de patogenia genética caracterizada pela atrofia parcial ou total das microvilosidades da mucosa do intestino delgado, hiperplasia de criptas e aumento do número de linfócitos intraepiteliais. Tem uma apresentação de forma variada, desde a forma clássica, até as formas atípicas e silenciosas sem os sintomas gastrointestinais 1,2 .…”

Section: Introductionunclassified

Complicações Da Doença Celíaca Associada Ao Transgresso À Dieta Isenta De Glúten

et al. 2018

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A Doença Celíaca (DC) é uma enteropatia de afecção crônica de patogenia genética caracterizada pela atrofia parcial ou total das microvilosidades da mucosa do intestino delgado. A ingestão do complexo proteico chamado "glúten" e de fragmentos derivados é fundamental para o desencadeamento desta doença, sendo responsável por promover a reação inflamatória que agride as vilosidades do intestino delgado. Este estudo teve como objetivo levantar dados por meio de uma revisão integrativa da literatura, acerca das complicações que o celíaco pode desenvolver em decorrência da transgressão à Dieta Isenta de Glúten (DIG). A estratégia de busca foi delineada nas bases de dados da Scientific Electronic Library Online (SciELO) e Medical Literature Analysis and Retrieval System Online (MedLine). No processo de busca, utilizou-se o operador booleano AND, na associação dos seguintes descritores: Doença Celíaca; Complicações; Dieta Livre de Glúten. Os critérios de inclusão dos artigos foram: estar disponível na integra, artigos publicados em periódicos nos últimos 10 anos, este período foi estabelecido devido à escassez de conteúdo na literatura, referente ao tema da pesquisa. O critério de exclusão se deu aos artigos que não fossem originais, teses, dissertações e monografias. A amostra final foi composta por 11 artigos. Com base nos resultados, as principais complicações que estão ligadas à DC são: linfoma, tireoidite de Hashimoto, diabetes mellitus tipo 1, osteoporose, além de a doença ser representada em pacientes com constipação e déficits nutricionais. O transgresso persistente à dieta isenta de glúten na doença celíaca pode atuar como fator de agravo ou no surgimento de doenças provindas de déficits nutricionais, provocadas pela inflamação da mucosa do intestino delgado. A presença da doença em si já aumenta as chances do aparecimento das patologias supracitadas.

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Increased Tissue Transglutaminase Levels Are Associated With Increased Epileptiform Activity in Electroencephalography Among Patients With Celiac Disease

Cited by 10 publications

References 27 publications

Neurophysiology of the “Celiac Brain”: Disentangling Gut-Brain Connections

Neurophysiology of the “Celiac Brain”: Disentangling Gut-Brain Connections

Cerebral hemodynamic changes to transcranial Doppler sonography in celiac disease: A pilot study

Complicações Da Doença Celíaca Associada Ao Transgresso À Dieta Isenta De Glúten

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