2006
DOI: 10.1258/000456306776021517
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Increased urinary dopamine excretion in association with bilateral carotid body tumours - clinical, biochemical and genetic findings

Abstract: This report describes a rare case of a patient with increased urinary dopamine excretion in association with bilateral carotid body tumours. Excretion of adrenaline, noradrenaline, metadrenaline, normetadrenaline and 4-hydroxy-3-methoxymandelic acid (HMMA) were within the reference ranges, and an 123 I-meta-iodobenzylguanidine (MIBG) scan showed uptake in the neck masses, with no other abnormal uptake anywhere else in the body. The patient is being managed conservatively as the tumours are not amenable to rese… Show more

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Cited by 12 publications
(4 citation statements)
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“…Biochemical testing for catecholamine-secreting tumors should be performed in symptomatic patients and those with a family history of CBT or other paragangliomas. 27 The imaging studies we most often use in these circumstances are 123 I-metaiodobenzylguanidine scin- tigraphy and CT or magnetic resonance of the chest and abdomen. CT angiography of the head and neck also provides excellent tumor characterization, defines the superior and medial extent of the tumor, identifies concomitant paragangliomas, and allows for tumor volume assessment.…”
Section: Discussionmentioning
confidence: 99%
“…Biochemical testing for catecholamine-secreting tumors should be performed in symptomatic patients and those with a family history of CBT or other paragangliomas. 27 The imaging studies we most often use in these circumstances are 123 I-metaiodobenzylguanidine scin- tigraphy and CT or magnetic resonance of the chest and abdomen. CT angiography of the head and neck also provides excellent tumor characterization, defines the superior and medial extent of the tumor, identifies concomitant paragangliomas, and allows for tumor volume assessment.…”
Section: Discussionmentioning
confidence: 99%
“…The urinary excretion of the O-methylated metabolite of dopamine, 3-methoxytyramine, was increased in 10 out of the 28 patients, but could be present in a variety of patients with or without pheochromocytomas, extra-adrenal paragangliomas, malignant disease, and producing glomus tumors. Interestingly, the elevated levels of 3-methoxytyramine in our study could be a reflection of the fact that we used the presence of HNP as an inclusion criterion, because carotid bodies are known to use dopamine as a neurotransmitter (Koch et al 2003, Jeffery et al 2006, Minguez-Castellanos et al 2007). We suspect HNP might continuously O-methylate dopamine and subsequently release methoxytyramine into the circulation, even in the absence of overt dopamine secretion.…”
Section: B Havekes Et Al: Screening In Sdhd Patientsmentioning
confidence: 97%
“…For the purpose of this study, 95 papers were reviewed. All papers were dealing with SDH germline mutations (57 in SDHD , 54 in SDHB and 13 in SDHC ) in patients affected by tumours related with the ‘PGL/PHEO syndromes’ [23–25, 31, 33, 35, 44–134]. These included all published reports cited in the Leiden Open Variation Database (LOVD) SDH gene databases at July 2008 (SDHB 080626: June 26, 2008; SDHC 080520: May 20, 2008; SDHD 080703: July 03, 2008) [135] and 13 recent publications.…”
Section: Sdh Germline Mutations Associated With Inherited Predispositmentioning
confidence: 99%