Increased volume density of peripheral mitochondria in skeletal muscle of children with exercise intolerance

Ekeren, G.J. van; Sengers, R. C. A.; Stadhouders, A. M.

doi:10.1016/0304-3991(89)90363-x

Cited by 2 publications

(2 citation statements)

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“…However, the comparison of children and adults in the present study shows different PCr decreases at the first exercise interval, which hints that children may better maintain muscle perfusion during the initial interval bout than adults, under comparable loads normalised to 1RM. In addition to differences in muscle perfusion, differences in mitochondrial capacity and fibre type recruitment may contribute to the different metabolic reactions observed for children and adults in this study (Bell et al 1980;van Ekeren et al 1991;Lexell et al 1992;Evans and Lexell 1995;Malina et al 2004;Dotan et al 2012).…”

Section: Discussionmentioning

confidence: 95%

Changes in phosphocreatine concentration of skeletal muscle during high-intensity intermittent exercise in children and adults

et al. 2013

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Section: Discussionmentioning

confidence: 95%

Changes in phosphocreatine concentration of skeletal muscle during high-intensity intermittent exercise in children and adults

et al. 2013

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“…A biochemical abnormality could not be found. Morphologically abnormal mitochondria and normal mitochondrial biochemistry have been encountered in several patients with nonprogressive muscular weakness and exercise intolerance (7).…”

Section: Discussionmentioning

confidence: 99%

Sudden Loss of Hearing and Vestibular Function, Muscular Weakness, and Multiple White Matter Lesions in Preschool Children

Lenard¹,

Voit²,

Lamprecht³

et al. 1992

Neuropediatrics

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Sudden cochlear hearing loss, occurring successively or simultaneously in both ears, was observed in four unrelated preschool children. Vestibular testing could be carried out in three patients and showed complete bilateral loss of function. All patients had a mildly retarded motor development due to nonprogressive muscular weakness. On MR imaging all patients showed multiple periventricular and subcortical white matter lesions. These lesions were not clearly progressive in one patient examined repeatedly over 6 years. Virological, bacteriological, immunological, and metabolic examinations were normal in all patients. Muscle biopsy showed morphologically abnormal mitochondria in two and lipid storage in one patient. No indications have been found for a disturbed functioning of the muscle mitochondria. The identical pattern and course of the disease in these patients suggests a new nosological entity, the aetiology of which can only speculatively be attributed to a vascular process associated with a mitochondriopathy.

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Increased volume density of peripheral mitochondria in skeletal muscle of children with exercise intolerance

Cited by 2 publications

References 0 publications

Changes in phosphocreatine concentration of skeletal muscle during high-intensity intermittent exercise in children and adults

Changes in phosphocreatine concentration of skeletal muscle during high-intensity intermittent exercise in children and adults

Sudden Loss of Hearing and Vestibular Function, Muscular Weakness, and Multiple White Matter Lesions in Preschool Children

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