Increased water transport in PDMS silicone films by addition of excipients

Borde, Annika; Larsson, Mikael; Odelberg, Ylva; Hagman, Joel H; Löwenhielm, Peter; Larsson, Anette

doi:10.1016/j.actbio.2011.09.022

Cited by 23 publications

(27 citation statements)

References 19 publications

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“…Resilience and elongation values are measure for elasticity of a material, and in the present case the polymer film has shown high values for elongation and was resilient upto an extent, displaying elastic nature of the material. [66] Hence, the mechanical parameters obtained for the CP-cl-poly(NVP) polymer film indicate that it meets the requirements for a potential wound dressing material. Compromised mechanical properties of hydrogels often limit the scope of their applications.…”

Section: Mechanical Propertiesmentioning

confidence: 77%

“…Hydrophilicity of the material results in water plasticization effect that will lead to polymer chain relaxation, increase in pore size and hence improved gaseous permeability. [65,66] Gaseous permeability especially for oxygen is a crucial factor for proper wound healing. On one side oxygen is necessary for regeneration of damaged tissue, while on the other side wound hypoxia leads to impaired wound healing.…”

Section: Mucoadhesion Studiesmentioning

confidence: 99%

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Functionalization of carbopol with NVP for designing antibiotic drug loaded hydrogel dressings for better wound management

Singh

Dhiman

2019

J Pharm Biopharm Res

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In the present work an attempt has been made to design the antibiotic drug loaded carbopolpoly(NVP) based hydrogel wound dressings for better wound care. The polymer films were characterized by SEM-EDX, AFM, FTIR, 13 CNMR, TGA/DTA/DTG, DSC, and swelling studies. Besides drug release, various biomedical properties (viz. blood compatibility, mucoadhesion, oxygen permeability, water vapour transmission rate, microbial penetration, tensile strength, bursting strength, resilience, stress relaxation, and folding endurance) have also been studied. The polymer films have been observed to be biocompatible, permeable to oxygen and water vapour and have absorbed simulated wound fluid 11.37±0.31g/g of polymer film. The drug release profile followed the Case-II diffusion mechanism and release profile best fitted in Hixson-Crowell's kinetic models. Mechanical properties results showed that the polymer film had 0.65±0.12 Nmm −2 tensile strength, 119.38±14.26% elongationand 25.49±0.72% resilience.

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Section: Mechanical Propertiesmentioning

confidence: 77%

Section: Mucoadhesion Studiesmentioning

confidence: 99%

Functionalization of carbopol with NVP for designing antibiotic drug loaded hydrogel dressings for better wound management

Singh

Dhiman

2019

J Pharm Biopharm Res

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“…Individuals with compromised skin barrier function, for example, still rely on the use of cumbersome occlusive dressings, often in combination with topical ointments that often fail due to poor patient compliance 3 . Although, existing flexible and skin-adherent preformed films interface with the skin 15,19,20,21 , these materials are not designed to serve as a 'second skin' that can be worn invisibly to restore normal skin recoil and aesthetics.…”

Section: Introductionmentioning

confidence: 99%

An elastic second skin

Yu¹,

Kang²,

Akthakul³

et al. 2016

Nature Mater

212

143

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We report the synthesis and application of an elastic, wearable crosslinked polymer layer (XPL) that mimics the properties of normal, youthful skin. XPL is made of a tunable polysiloxane-based material that can be engineered with specific elasticity, contractility, adhesion, tensile strength and occlusivity. XPL can be topically applied, rapidly curing at the skin interface without the need for heat-or light-mediated activation. In a pilot human study, we examined the performance of a prototype XPL that has a tensile modulus matching normal skin responses at low strain (< 40%), and that withstands elongations exceeding 250%, elastically recoiling with minimal strain-energy loss on repeated deformation. The application of XPL to the herniated lower-eyelid fat pads of 12 subjects resulted in an average 2-grade decrease in herniation appearance in a 5-point severity scale. The XPL platform may offer advanced solutions to compromised skin barrier function, pharmaceutical delivery, and wound dressings.

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“…Simultaneously, CLSM was performed. It enables to visualize the water uptake in the film during the first days of immersion . Fluorescein was added to water in order to observe water whereas Nile Red was used to visualize polymer films.…”

Section: Resultsmentioning

confidence: 99%