The Indian Ganga Basin (IGB) is one of the most valuable socioeconomic regions in the Indian subcontinent. The IGB supports more than half a billion people due to an abundant supply of freshwater for agro-industrial purposes, primarily through Indian Summer Monsoon (ISM) rainfall contributions (~85%). Any alterations in ISM characteristics would significantly affect freshwater availability, and as a result, socioeconomic activities would be affected. Therefore, in this study, we have attempted to assess how the monsoon rain spell characteristics, i.e., peak, volume, and duration, altered historically between 1901 to 2019. We further analyzed the specific IGB regions where monsoon rain spell changes are more prominent and their hydrological implications. Our estimates reveal that short-duration high-magnitude rain spells have significantly increased across the major regions of the IGB after 1960, which implies the increased probabilities of flash flood hazards. At the same time, the rain spell volumes have been depleted across the IGB after 1960, especially in the eastern Indo-Gangetic plains and southern IGB regions, indicating increased drought frequencies. Further, Himalayan regions, i.e., upper Ganga, upper Yamuna, and upper Ghaghra, have demonstrated increasing magnitudes of rain spell peaks, volume, and duration post-1960. In addition, the continuous warming and anthropogenic alterations might further exaggerate the current situation. Thus, these inferences are helpful for river basin management strategies to deal with the extreme hydrological disasters in the IGB.