Increasing heterogeneity in the organization of synaptic inputs of mature olfactory bulb neurons generated in newborn rats

Kelsch, Wolfgang; Sim, Shuyin; Lois, Carlos

doi:10.1002/cne.22799

Cited by 11 publications

(9 citation statements)

References 84 publications

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“…This antiserum stains a single band at ∼50–55 kDa as observed by western blot analysis of fibroblast‐like BHK 21 C13 cells (Archer et al, ). Moreover, omission of rabbit anti‐c‐Fos antibody resulted in no labeled cells (data not shown; Ingham et al, ; Kelsch et al, ).…”

Section: Methodsmentioning

confidence: 94%

Immunocytochemical organization and sour taste activation in the rostral nucleus of the solitary tract of mice

Stratford

Thompson

Finger

2016

J of Comparative Neurology

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Sensory inputs from the oropharynx terminate in both the trigeminal brainstem complex and the rostral part of the nucleus of the solitary tract (nTS). Taste information is conveyed via the facial and glossopharyngeal nerves while general mucosal innervation is carried by the trigeminal and glossopharyngeal nerves. In contrast, the caudal nTS receives general visceral information largely from the vagus nerve. Although the caudal nTS shows clear morphological and molecularly delimited subdivisions, the rostral part does not. Thus, linking taste-induced patterns of activity to morphological subdivisions in the nTS is challenging. To test whether molecularly-defined features of the rostral nTS correlate with patterns of taste-induced activity, we combined immunohistochemistry for markers of various visceral afferent and efferent systems with c-Fos-based activity maps generated by stimulation with a sour tastant, 30mM citric acid. We further dissociated taste-related activity from activity arising from acid-sensitive general mucosal innervation by comparing acid-evoked c-Fos in wildtype and “taste blind”, P2X2/P2X3 double knockout (P2X-dblKO) mice. In wildtype mice, citric acid stimulation evoked significant c-Fos activation in the central part of the rostral nTS – activity that was largely absent in the P2X-dblKO mice. P2X-dblKO mice, like wildtype mice, did exhibit acid-induced c-Fos activity in the dorsomedial trigeminal brainstem nucleus situated laterally adjacent to the rostral nTS. This dorsomedial nucleus also showed substantial innervation by trigeminal nerve fibers immunoreactive for CGRP, a marker for polymodal nociceptors suggesting that trigeminal general mucosal innervation carries information about acids in the oral cavity.

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Section: Methodsmentioning

confidence: 94%

Immunocytochemical organization and sour taste activation in the rostral nucleus of the solitary tract of mice

Stratford

Thompson

Finger

2016

J of Comparative Neurology

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“…In the embryo, the key tissue elements, such as blood–brain barrier (Hagan and Ben-Zvi 2015), astrocyte (Jacobsen and Miller 2003; Rowitch and Kriegstein 2010) and oligodendrocyte cells (Kessaris et al 2006), or stable neuronal circuitry (Kelsch et al 2012; Luhmann et al 2014), are either not present or undergoing development. Absence of these elements is bound to influence the way humoral factors, such as growth factors or neurotransmitters, can affect cellular processes.…”

Section: Neurotransmitter Signaling In Embryonic and Adult Neurogenesismentioning

confidence: 99%

Neurogenesis in the Developing and Adult Brain—Similarities and Key Differences

Götz

Nakafuku

Petrik

2016

Cold Spring Harb Perspect Biol

127

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Adult neurogenesis in the mammalian brain is often viewed as a continuation of neurogenesis at earlier, developmental stages. Here, we will critically review the extent to which this is the case highlighting similarities as well as key differences. Although many transcriptional regulators are shared in neurogenesis at embryonic and adult stages, recent findings on the molecular mechanisms by which these neuronal fate determinants control fate acquisition and maintenance have revealed profound differences between development and adulthood. Importantly, adult neurogenesis occurs in a gliogenic environment, hence requiring adult-specific additional and unique mechanisms of neuronal fate specification and maintenance. Thus, a better understanding of the molecular logic for continuous adult neurogenesis provides important clues to develop strategies to manipulate endogenous stem cells for the purpose of repair.

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“…Number of ambulation, rearing, and grooming during the 3-minute observation period was counted [22] . The heart rate and serum sodium concentration were measured immediately after open field activity.…”

Section: Effect On Behavioral and Physiological Parameters During Opementioning

confidence: 99%

Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats

Aswar¹,

Kalshetti²,

Shelke

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Increasing heterogeneity in the organization of synaptic inputs of mature olfactory bulb neurons generated in newborn rats

Cited by 11 publications

References 84 publications

Immunocytochemical organization and sour taste activation in the rostral nucleus of the solitary tract of mice

Immunocytochemical organization and sour taste activation in the rostral nucleus of the solitary tract of mice

Neurogenesis in the Developing and Adult Brain—Similarities and Key Differences

Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats

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