Increasing Incidence and Decreasing Mortality of Cutaneous Melanoma in Middle-Aged Adults: An Epidemiologic Study in Olmsted County, Minnesota

Campbell, Elliott H.; Reinhart, Jacob P.; Crum, Olivia M.; Proffer, Sydney L.; Weaver, Amy L.; Gibson, Lawrence E.; Brewer, Jerry D.; Demer, Addison M.

doi:10.1016/j.mayocp.2022.10.029

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…This finding is consistent with data from the middle-aged cohort (40-60 year old). 14 Based on this projection, females may overcome male melanoma diagnosis rates in Minnesota for this age group in the next 10 years. This is a unique and statistically significant finding that is higher than previously reported studies 15 and distinct from previous reported cohorts from 1970 to 2009.…”

Section: Discussionmentioning

confidence: 99%

Increasing Incidence and Decreasing Mortality of Melanoma in Elderly Adults: An Epidemiologic Study in Olmsted County, Minnesota

Proffer,

Reinhart,

Campbell

et al. 2023

Dermatol Surg

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BACKGROUND AND OBJECTIVE Primary cutaneous melanoma incidence is increasing in elderly individuals. This population-based cohort examines incidence and mortality rates among adults aged 61 years and older with cutaneous melanoma. MATERIALS AND METHODS Using the Rochester Epidemiology Project, patients aged 61 years of age or older with a first lifetime diagnosis of cutaneous melanoma between January 1, 1970 and December 31, 2020 were identified. RESULTS The age- and sex-adjusted incidence rate increased from 16.4 (95% CI, 8.2–24.6) per 100,000 person-years in 1970 to 1979 to 201.5 (95% CI, 185.1–217.8) per 100,000 person-years in 2011 to 2020 (12.3-fold increase). There was a 16.0x increase in males and an 8.5× increase in females. Melanoma incidence has stabilized in males (1.2-fold increase, p = .11) and continues to significantly increase in females (2.7-fold increase, p < .001). Older age at diagnosis was significantly associated with an increased risk of death (HR 1.23 per 5-year increase in age at diagnosis, 95% CI, 1.02–1.47). CONCLUSION Melanoma incidence continues to increase since 1970. The incidence has risen in elderly females, but has stabilized in males. Mortality has decreased throughout this period.

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Section: Discussionmentioning

confidence: 99%

Increasing Incidence and Decreasing Mortality of Melanoma in Elderly Adults: An Epidemiologic Study in Olmsted County, Minnesota

Proffer,

Reinhart,

Campbell

et al. 2023

Dermatol Surg

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“…Malignant melanoma is a neoplasm that has morbidity and mortality associated if not managed early, underscoring the need to identify early signs of disease [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

The Utility of Radiologic Imaging and Full Body Skin Examination in Patients With Melanoma of Unknown Primary

ShamaeiZadeh,

Campbell,

Comfere

2024

Cureus

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Although most melanomas have a cutaneous origin, melanomas are rarely discovered without an overt primary site and are found in the metastatic stage. This phenomenon is called melanoma of unknown primary (MUP), which was first recorded in 1963. Melanoma can also rarely present as tumoral melanosis, which has completely regressed. By definition, this does not have viable melanocytes and histologically presents as an infiltration of melanophages and melanin. A 71-year-old female presented for dermatologic evaluation after being found to have melanoma of unknown primary (MUP). The MUP, located in multiple lymph nodes of the left superior and inferior inguinal region, was found on preoperative imaging indicated for surgical management of endometrial carcinoma. After the biopsy, a positron emission tomographycomputed tomography (PET-CT) scan was performed to determine the extent of involvement, which noted focal uptake of the left heel of just medial to midline with an SUV max of 2.1. Based on the PET-CT findings, the patient was questioned about the lesion on her heel. She had suspected this was due to friction and stated it had been asymptomatic and present for years. This unique case demonstrates that combined total skin examination and whole-body radiologic imaging (preferably PET-CT) are both critical elements in the evaluation of MUP. Since melanoma of unknown primary is at least American Joint Committee on Cancer (AJCC) 8 Stage III (due to N1 status), imaging is reasonable in these patients.

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Integrated analysis reveals SMARCD1 is a potential biomarker and therapeutic target in skin cutaneous melanoma

Chen

et al. 2023

J Cancer Res Clin Oncol

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Increasing Incidence and Decreasing Mortality of Cutaneous Melanoma in Middle-Aged Adults: An Epidemiologic Study in Olmsted County, Minnesota

Cited by 4 publications

References 16 publications

Increasing Incidence and Decreasing Mortality of Melanoma in Elderly Adults: An Epidemiologic Study in Olmsted County, Minnesota

Increasing Incidence and Decreasing Mortality of Melanoma in Elderly Adults: An Epidemiologic Study in Olmsted County, Minnesota

The Utility of Radiologic Imaging and Full Body Skin Examination in Patients With Melanoma of Unknown Primary

Integrated analysis reveals SMARCD1 is a potential biomarker and therapeutic target in skin cutaneous melanoma

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