Increasing incidence of colorectal cancer in Asia: implications for screening

Sung, Joseph J.Y.; Lau, James; Goh, Kazutomo; Leung, Wai K.

doi:10.1016/s1470-2045(05)70422-8

Cited by 681 publications

(498 citation statements)

References 25 publications

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“…Colorectal cancer (CRC) is the third most common cancer worldwide and its incidence has risen rapidly in Asian countries during the past few decades (1,2). It has been established that environmental and hereditary factors contribute to the initiation and development of CRC, as indicated by the accumulation of mutations in oncogenes (3).…”

Section: Introductionmentioning

confidence: 99%

Interleukin-6 stimulates aerobic glycolysis by regulating PFKFB3 at early stage of colorectal cancer

Han

Meng

et al. 2015

International Journal of Oncology

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Abstract. Chronic inflammation is a well-known etiological factor for colorectal cancer (CRC) and cancer cells are known to preferentially metabolize glucose through aerobic glycolysis. However, the connection between chronic inflammation and aerobic glycolysis in the development of CRC is largely unexplored. The present study investigated whether interleukin-6 (IL-6), a pro-inflammatory cytokine, promotes the development of CRC by regulating the aerobic glycolysis and the underlying molecular mechanisms. In colitis-associated CRC mouse, anti-IL-6 receptor antibody treatment reduced the incidence of CRC and decreased the expression of key genes in aerobic glycolysis, whereas the plasma concentrations of glucose and lactate were not affected. Consistently, IL-6 treatment stimulated aerobic glycolysis, upregulated key genes in aerobic glycolysis and promoted cell proliferation and migration in SW480 and SW1116 CRC cells. 6-phoshofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) was the most downregulated gene by anti-IL-6 receptor antibody in colorectal adenoma tissues. Further analysis in human samples revealed overexpression of PFKFB3 in colorectal adenoma and adenocarcinoma tissues, which was also associated with lymph node metastasis, intravascular cancer embolus and TNM stage. In addition, the effect of IL-6 on CRC cells can be abolished by knocking down PRKFB3 through siRNA transfection. Our data suggest that chronic inflammation promotes the development of CRC by stimulating aerobic glycolysis and IL-6 is functioning, at least partly, through regulating PFKFB3 at early stage of CRC.

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Section: Introductionmentioning

confidence: 99%

Interleukin-6 stimulates aerobic glycolysis by regulating PFKFB3 at early stage of colorectal cancer

Han

Meng

et al. 2015

International Journal of Oncology

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“…The incidence of colorectal cancer is rising in many countries (Béjar et al, 2012) as well as in the Asian region (Sung et al, 2005). In Malaysia, colorectal cancer is the most common cancer in males and the third most common in females (National Cancer Registry, 2006) with majority of patients are above 50 years old (National Cancer Patient Registry, 2010).…”

Section: Introductionmentioning

confidence: 99%

Participation and Barriers to Colorectal Cancer Screening in Malaysia

Yusoff¹,

Daud²,

Norhayati³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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In Malaysia, colorectal cancer is the most common cancer in males and the third most common in females. Mortality due to colorectal cancer can be effectively reduced with early diagnosis. This study was designed to look into colorectal cancer screening participation and its barriers among average risk individuals in Malaysia. .0%), respectively. There were 11.2% of respondents who never received any advice to do screening. The main reason for them to undergo screening was being advised by health care providers (84.6%). The study showed that participation in colorectal cancer screening in Malaysia is extremely low and multiple factors contribute to this situation. Given the importance of the disease, efforts should be made to increase colorectal cancer screening activities in Malaysia.

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“…China, Japan, and South Korea have experienced an increase of two to four times in the incidence of CRC during the past few decades (Sung et al, 2005), and more than 700,000 new CRC cases occur in ASEAN (the Association of Southeast Asian Nations) countries (Kimman et al, 2012). The definite mechanism of CRC development is still unclear, both environmental factors and genetic susceptibility are considered as risk factors.…”

Section: Introductionmentioning

confidence: 99%

Association Between Green Tea and Colorectal Cancer Risk: A Meta-analysis of 13 Case-control Studies

Wang

Zeng²,

Duan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: Experimental studies have suggested green tea to be a chemopreventive agent for colorectal cancer, and many studies have examined possible associations. However, the conclusions were inconsistent or even contradictory, so we performed a meta-analysis based on published case-control studies to explore if green tea is indeed a protective factor. Methods: PubMed was searched up to May 10 th , 2012 for relevant studies, and references of included studies were manually searched. Finally 13 eligible studies, involving 12,636 cases and 38,419 controls were identified. After data extraction, a meta-analysis was performed using CMA v2 software. Results: The results indicated there may be a weak but not statistically significant reduced risk of colorectal cancer with high dose of green tea intake (OR=0.95, 95% CI:0.81-1.11, p=0.490.69-0.98). This protective effect was also found in all subgroups, except in American and European populations. Sensitivity analysis indicated the result to be robust. Publication bias was not detected by either funnel plot or Egger tests. Conclusion: The results of this meta-analysis indicate a weak lower tendency for colorectal cancer development with green tea consumption, but available epidemiologic data are insufficient to conclude that green tea may protect against colorectal cancer in humans.

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Increasing incidence of colorectal cancer in Asia: implications for screening

Cited by 681 publications

References 25 publications

Interleukin-6 stimulates aerobic glycolysis by regulating PFKFB3 at early stage of colorectal cancer

Interleukin-6 stimulates aerobic glycolysis by regulating PFKFB3 at early stage of colorectal cancer

Participation and Barriers to Colorectal Cancer Screening in Malaysia

Association Between Green Tea and Colorectal Cancer Risk: A Meta-analysis of 13 Case-control Studies

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