The purpose of the research is the defining the role of spatial interaction marketing in agribusiness sustainable development in the framework of the general focus on the positively evolved regional economy. We relied on a meaningful analysis of literature sources, expert opinions representing the value guidelines of the concept of sustainable development, changes in marketing theory, social attitudes that characterize the success of business relationships and the essence of the concept of marketing of spatial interaction. We have examined the points of view on ongoing initiatives in terms of the agribusiness projects development in a number of Russian regions. The following methods were used: analysis of the content of literary sources, expert opinions, analogies, meaningful and comparative analysis, synthesis of the data obtained in obtaining conclusions. An important result is the substantiation of the approach to the fact that changes that take into account modern targets for the positive evolution of the territory and its agribusiness sustainable sector are in the pool of solutions for the spatial interaction marketing, practical implementation of which will take into account, along with economic, social and environmental effects, that will give impetus to the necessary transformations for the sake of common interests.