There are different characteristics distinguishing a region from the others, thereby, leading to the diversities in the regional potentials and problems as well as the strategic regional development policies to be implemented. The East-West Corridor is one of the eleven provincial strategic economic areas in West Sumatra. It covers nine regencies or cities and 65 sub-districts with different characteristics and typologies and this leads to diversity in the strategies to develop this area. This study aims to determine the diversity associated with the characteristics and typologies of the strategic area of the East-West Corridor. This involved using Principal Component Analysis (PCA) analysis technique, spatial clustering analysis, and overlay analysis. Moreover, the regional characteristics and typologies were grouped based on 17 observational variables used in producing four main components including trade and tourism services, agriculture, livestock/fishery, and tourism. The results of spatial clustering analysis produced 3 clusters which are the urban, desa-kota, and rural areas while the overlay analysis produced ten regional characteristics and typologies used as the basis to make strategies and policies for each region’s development and to increase investment opportunities in the strategic area of West-East Corridor and the Province of West Sumatra in general.