Increasing quinolone resistance and multidrug resistant isolates among Salmonella enterica in Hong Kong

Lo, Norman; Chu, Man-Yu; Ling, J. M.

doi:10.1016/j.jinf.2012.08.016

Cited by 10 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…is an increasing problem. 6 Based on susceptibility testing results of nalidixic acid and CIP, quinolone resistance can be ranked at three levels: resistant to CIP (resistant to both drugs), of reduced CIP susceptibility (resistant to nalidixic acid and intermediate to CIP), and susceptible to both drugs. 7 Recently, particular concern has been raised about highly CIP-resistant strains of several Salmonella serotypes circulating in both human beings and the environment.…”

Section: Introductionmentioning

confidence: 99%

Overview of the development of quinolone resistance in <em>Salmonella</em> species in China, 2005–2016

Song¹,

Xu²,

Gao³

et al. 2018

IDR

View full text Add to dashboard Cite

PurposeSeveral factors contribute to the complexity of quinolone resistance in Salmonella, including >2000 different Salmonella serotypes, a variety of hosts for Salmonella, and wide use of quinolones in human beings and animals. We thus aimed to obtain an overview of the development of quinolone resistance and relevant molecular mechanisms of such a resistance in Salmonella species.Materials and methodsA total of 1,776 Salmonella isolates were collected in Ningbo, China, between 2005 and 2016. Antimicrobial susceptibility to quinolone and relevant genetic mechanisms in these isolates were retrospectively analyzed.ResultsThe ratio for ciprofloxacin (CIP) resistant:reduced CIP susceptible:CIP susceptible was 26:522:1,228. CIP resistance was found in nine of 51 serotypes: Derby, London, Kentucky, Indiana, Corvallis, Rissen, Hadar, Typhimurium, and Agona. Of 26 CIP-resistant isolates, all were concurrently resistant to ampicillin and 21 were also concurrently resistant to cefotaxime and produced extended-spectrum β-lactamase (ESBL). The minimal inhibitory concentration values were at three levels: 2–4 μg/mL (serotypes except for Kentucky and Indiana), 16 μg/mL (one Kentucky isolate), and >32 μg/mL (Indiana isolates). As with the three most common serotypes, Salmonella Typhi showed quickly increased prevalence of reduced CIP susceptibility in recent years, Salmonella Enteritidis remained at a high prevalence of reduced CIP susceptibility throughout the study period, and several isolates of Salmonella Typhimurium were resistant to CIP. Transferable plasmid-mediated quinolone resistance gene qnrB was only found in all CIP-resistant isolates. In contrast, gyrA mutations were often found in reduced CIP-susceptible isolates and were not necessarily found in all CIP-resistant isolates.ConclusionWe conclude that in Salmonella, there exists a high prevalence of reduced CIP susceptibility and a low prevalence of CIP resistance, which focuses on several serotypes. Our study also demonstrates that, rather than gyrA mutations, qnrB is the most common indicator for CIP resistance.

show abstract

Section: Introductionmentioning

confidence: 99%

Overview of the development of quinolone resistance in <em>Salmonella</em> species in China, 2005–2016

Song¹,

Xu²,

Gao³

et al. 2018

IDR

View full text Add to dashboard Cite

show abstract

“…The antimicrobial susceptibilities of 275 Salmonella Enteritidis strains isolated from 1986 to 1996 show that over 99% of the isolates are susceptible to 17 of the 19 antimicrobial agents tested [12]. From 2005 to 2010, Salmonella Enteritidis was the predominant serovar in Hong Kong; in that time, the strains that were not susceptible to ciprofloxacin increased significantly, from 39.3% to 63%, and the percentage of multidrug resistant (MDR) strains increased from 17.8% to 36.2% [13]. In an inland province, Henan, the two most common serovars among the isolates collected during 2006 and 2007 were Salmonella Typhimurium (27%) and Salmonella Enteritidis (17%) [14].…”

Section: Introductionmentioning

confidence: 99%

Serovar distribution, antimicrobial resistance profiles, and PFGE typing of Salmonella enterica strains isolated from 2007–2012 in Guangdong, China

Sun

et al. 2014

BMC Infect Dis

View full text Add to dashboard Cite

BackgroundSalmonella enterica includes the major serovars associated with human salmonellosis. In this study, 1764 clinical Salmonella enterica isolates from diarrhea outpatients were collected from fifteen cities in Guangdong province, China, between 2007 and 2012. These isolates represent all of the Salmonella isolates collected from the province during that period.MethodsThe isolates were characterized by serovar determination, antimicrobial susceptibility tests and PFGE fingerprint typing.ResultsThe serovar distribution results demonstrated that Salmonella Typhimurium (n = 523, 29.65%) and Salmonella 4,5,12:i:- (n = 244, 13.83%) are the most common serovars causing infant salmonellosis, whereas Salmonella Enteritidis (n = 257, 14.57%) mainly causes human salmonellosis in adults. The serovar shift from Salmonella Enteritidis to Salmonella Typhimurium occurred in 2008. Antimicrobial susceptibility data showed a high burden of multidrug resistance (MDR) (n = 1128, 56.58%), and a 20%-30% increase in the number of isolates resistant to ciprofloxacin (n = 142, 8.05%) and third-generation cephalosporins (n = 88, 4.99%) from 2007–2012. Only 9.97% of isolates (n = 176) were fully susceptible to all agents tested. A high burden of MDR was observed in Salmonella Typhimurium and Salmonella 4,5,12:i:- for all age groups, and a reduced susceptibility to third-generation cephalosporins and quinolones occurred particularly in infants (≤6 years). The dominant PFGE patterns were JPXX01.GD0004, JEGX01.GD0006-7 and JNGX01.GD0006-7. ACSSuT was the predominant MDR profile in the Salmonella Typhimurium & 4,5,12:i:- complexes, while ASSuT-Nal and ASSu-Nal were the major MDR profiles in Salmonella Enteritidis. The predominant PFGE patterns of the Salmonella Typhimurium & 4,5,12:i:- complexes and Salmonella Stanley were most prevalent in infants (≤6 years). However, no obvious relationship was observed between these PFGE profiles and geographic location.ConclusionsThese data reveal the serovar distribution of isolates recovered from diarrhea patients, the characteristics of resistant strains and fingerprint typing in Guangdong from 2007 to 2012. These results highlight a serovar shift and a worrying percentage of MDR strains with increasing resistance to quinolones and third-generation cephalosporins. Thus, continued surveillance of Salmonella and their MDR profiles using combined molecular tools and efforts to control the rapid increase in antimicrobial resistance among Salmonella in Guangdong are needed.

show abstract

“…In the United States, S. Enteritidis has become the most clinically prevalent serotype since 2008, accounting for ϳ17% of all salmonellosis cases (2). In other countries, the prevalence of S. Enteritidis is even higher, reaching Ͼ50% in European countries and Hong Kong (1,(3)(4)(5). Most importantly, S. Enteritidis is commonly associated with outbreaks of foodborne illness and is sometimes associated with invasive Salmonella infections worldwide (6).…”

mentioning

confidence: 99%

IncI1 Plasmids Carrying Various bla _CTX-M Genes Contribute to Ceftriaxone Resistance in Salmonella enterica Serovar Enteritidis in China

Wong

Kan

Chan

et al. 2016

Antimicrob Agents Chemother

View full text Add to dashboard Cite

cResistance to extended-spectrum ␤-lactams in Salmonella, in particular, in serotypes such as Salmonella enterica serovar Enteritidis that are frequently associated with clinical infections, is a serious public health concern. In this study, phenotypic characterization of 433 clinical S. Enteritidis strains obtained from a nationwide collection of the Chinese Center for Disease Control and Prevention during the period from 2005 to 2010 depicted a trend of increasing resistance to ceftriaxone from 2008 onwards. Seventeen (4%) of the strains were found to be resistant to ceftriaxone, 7% were found to be resistant to ciprofloxacin, and 0.7% were found to be resistant to both ciprofloxacin and ceftriaxone. Most of the ceftriaxone-resistant S. Enteritidis strains (15/17) were genetically unrelated and originated from Henan Province. The complete sequence of an IncI1 plasmid, pSE115, which belonged to a novel sequence type, was obtained. This 87,255-bp IncI1 plasmid was found to harbor a bla CTX-M-14 gene in a novel multidrug resistance region (MRR) within the tra locus. Although the majority of strains were also found to contain conjugative IncI1 plasmids with a size similar to that of pSE115 (ϳ90 kb) and harbor a variety of bla CTX-M group 1 and group 9 elements, the novel MRR site at the tra locus in pSE115 was not detectable in the other IncI1 plasmids. The findings from this study show that cephalosporin resistance in S. Enteritidis strains collected in China was mainly due to the dissemination of IncI1 plasmids carrying bla CTX-M , resembling the situation in which IncI1 plasmids serve as major vectors of bla CTX-M variants in other members of the Enterobacteriaceae. Foodborne salmonellosis is a serious public health problem worldwide and the leading cause of foodborne illnesses in many countries, including the United States and China. Salmonella enterica subsp. enterica serovar Enteritidis is the most common serotype that causes human infections in China (1). In the United States, S. Enteritidis has become the most clinically prevalent serotype since 2008, accounting for ϳ17% of all salmonellosis cases (2). In other countries, the prevalence of S. Enteritidis is even higher, reaching Ͼ50% in European countries and Hong Kong (1, 3-5). Most importantly, S. Enteritidis is commonly associated with outbreaks of foodborne illness and is sometimes associated with invasive Salmonella infections worldwide (6). Although antimicrobials are usually not required for the treatment of salmonellosis due to the self-limiting nature of this disease, they can be lifesaving in patients with invasive infections, which normally occur in children, the elderly, and immunocompromised patients (7).Ceftriaxone and ciprofloxacin are the key drugs of choice for the treatment of invasive Salmonella infections in humans (8).Resistance to ceftriaxone or other extended-spectrum ␤-lactams is usually due to the production of extended-spectrum ␤-lactamases (ESBLs), among which the CTX-M-type ESBLs are largely responsible for cephalosporin resista...

show abstract

Increasing quinolone resistance and multidrug resistant isolates among Salmonella enterica in Hong Kong

Cited by 10 publications

References 27 publications

Overview of the development of quinolone resistance in <em>Salmonella</em> species in China, 2005–2016

Overview of the development of quinolone resistance in <em>Salmonella</em> species in China, 2005–2016

Serovar distribution, antimicrobial resistance profiles, and PFGE typing of Salmonella enterica strains isolated from 2007–2012 in Guangdong, China

IncI1 Plasmids Carrying Various bla _CTX-M Genes Contribute to Ceftriaxone Resistance in Salmonella enterica Serovar Enteritidis in China

Contact Info

Product

Resources

About

Increasing quinolone resistance and multidrug resistant isolates among Salmonella enterica in Hong Kong

Cited by 10 publications

References 27 publications

Overview of the development of quinolone resistance in <em>Salmonella</em> species in China, 2005&ndash;2016

Overview of the development of quinolone resistance in <em>Salmonella</em> species in China, 2005&ndash;2016

Serovar distribution, antimicrobial resistance profiles, and PFGE typing of Salmonella enterica strains isolated from 2007–2012 in Guangdong, China

IncI1 Plasmids Carrying Various bla CTX-M Genes Contribute to Ceftriaxone Resistance in Salmonella enterica Serovar Enteritidis in China

Contact Info

Product

Resources

About

Overview of the development of quinolone resistance in <em>Salmonella</em> species in China, 2005–2016

Overview of the development of quinolone resistance in <em>Salmonella</em> species in China, 2005–2016

IncI1 Plasmids Carrying Various bla _CTX-M Genes Contribute to Ceftriaxone Resistance in Salmonella enterica Serovar Enteritidis in China