Aim. To assess the state of the scientific potential of the Magadan Oblast from the point of view of its influence on the formation of economic security of the region.Objectives. To define the concept of “scientific potential of the region” and reveal its structure; to consider the existing approaches to assessing the scientific potential of the region; to conduct a comparative analysis of the scientific potential of the Magadan Oblast and the Far Eastern Federal District (FEFD).Methods. The scientific potential of the region is considered in the plane and component aspects from the position of three components: technological, innovative, educational. The assessment of each component is based on three interrelated planes: formation, development and utilization.Results. The tendency to decrease the scientific potential of the Magadan Oblast in all three components both in absolute terms and in comparison with the indicators of the Far Eastern Federal District has been revealed. The greatest reduction of indicators is revealed in the sphere of scientific and technological potential.Conclusions. There is a growing threat to the economic security of the region due to the lag of the Magadan Oblast from other regions of the Far Eastern Federal District both on the level of innovation and technological development and on the formation of scientific personnel for the needs of the regional economy. It is recommended to concentrate efforts in the sphere of development of scientific and educational potential, since it is the sphere that determines the strategic development of the region and long-term economic security.