Increasing trend in atopy markers prevalence in a Croatian adult population between 1985 and 1999

Macan, Jelena; Varnai, Veda Marija; Maloča, Ivana; Kanceljak-Macan, Božica

doi:10.1111/j.1365-2222.2007.02836.x

Cited by 14 publications

(15 citation statements)

References 29 publications

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“…We included the following covariates that were either significant on univariate testing (Table 1), or important for allergic sensitization or atopic diseases based on the literature: age (18-24, 25-39, 30-34, and 35-39 years), education (primary school or lower, junior middle school, high school or higher), occupation (farmer/non-farmer), cockroach in house (none, occasional, some, or many), and tobacco exposure (passive exposure for women)3, 27. We also tested the linear trends across quartiles of adiposity measures and lipid levels, and across BMI categories.…”

Section: Methodsmentioning

confidence: 99%

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Adiposity, serum lipid levels, and allergic sensitization in Chinese men and women

Ouyang¹,

Kumar²,

Pongracic³

et al. 2009

Journal of Allergy and Clinical Immunology

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Section: Methodsmentioning

confidence: 99%

“…Over recent decades, the worldwide prevalence of obesity,1 allergic sensitization and atopic diseases2, 3 has risen dramatically. There is increasing evidence that excess adiposity and metabolic syndrome are associated with chronic systemic inflammation4 and asthma 5, 6.…”

Section: Introductionmentioning

confidence: 99%

Adiposity, serum lipid levels, and allergic sensitization in Chinese men and women

Ouyang¹,

Kumar²,

Pongracic³

et al. 2009

Journal of Allergy and Clinical Immunology

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“…Sensitisation to common allergens and development of typical symptoms of an allergic disease usually occurs in childhood and adolescence. However, a recent study has shown a signifi cant increase in the prevalence of atopy markers (IgE antibodies, positive skin prick test) in Croatian adult population in the period between 1985 and 1999, particularly in men (43). The reasons for the fi rst occurrence of atopic diseases in adulthood are still unknown.…”

Section: Discussionmentioning

confidence: 99%

Is Atopy Related to Neuroticism, Stress, and Subjective Quality of Life?

Radošević-Vidaček

Košćec

Bakotić

et al. 2009

Archives of Industrial Hygiene and Toxicology

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Different psychosocial characteristics have been associated with allergic disorders. The aim of this study was to examine whether atopic constitution and reports of allergic symptoms were related to personality trait of neuroticism, exposure to stressful life events and estimates of quality of life. Atopy was determined by skin prick test and reports of nasal and pulmonary allergy-related symptoms. Actively working individuals of both genders took part in the study (n=145, age range: 20 to 66 years). The participants were divided in three groups. The fi rst group was composed of those with negative skin prick test and without symptoms (n=57), the second of those with positive skin prick test but without symptoms (n=28), and the third of those with positive skin prick test and symptoms (n=60). The groups did not differ signifi cantly in neuroticism, exposure to stressful life events, or quality of life. Women reported more pronounced neuroticism and anxiety, higher exposure to stressful life events, and were less satisfi ed with their environment than men. In our sample of active workers we found no association of neuroticism, exposure to stressful life events, and quality of life with atopy and allergic symptoms.

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“…The incidence of atopic disorders such as asthma, allergic rhinoconjunctivitis, and atopic eczema has increased over the past two decades in many countries including Croatia (1). Atopy is a complex genetic disease that results from the interplay between gene variants and environmental influences (2).…”

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confidence: 99%

Soluble CD14 and total IgE in the serum of atopic and nonatopic adolescents in relation to environmental factors: a pilot study / Topivi receptor CD14 i ukupni IgE u serumu mladih atopičara odrasle dobi u ovisnosti o čimbenicima iz okoliša: pilot istraživanje

Prester

Varnai

Macan

2015

Archives of Industrial Hygiene and Toxicology

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The CD14 receptor is expressed on the surfaces of monocytes, macrophages, and, to a lesser extent, of activated granulocytes and B lymphocytes (mCD14). It also exists in soluble form in the serum (sCD14), in which it binds microbial compounds and indoor allergens. The objectives of this study were to see whether serum sCD14 concentrations could be used as a marker of atopic disorders and to estimate the effects of environmental factors (tobacco smoke exposure, childhood residence in urban or rural areas, and having a pet) on sCD14 and IgE values. Mass fraction of sCD14 and total IgE were determined in the sera of atopic (N=53) and non-atopic (N=35) participants using the standard enzyme-linked immunosorbent assay. Exposure to pets and environmental tobacco smoke was estimated based on the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC). Median sCD14 concentration was significantly lower in atopic than in non-atopic girls (3.49 vs. 3.83 μg mL -1 ; p<0.010). The number of smokers at home positively correlated with the sCD14 level in atopics, and urban atopics had significantly lower sCD14 levels than rural atopics (3.47 vs. 3.92 μg mL -1 , p=0.028). Median total IgE concentration was significantly lower in atopic pet owners than in atopics with no pets (161 vs. 252 kIU L -1 ; p=0.021). In conclusion, while sex and environmental factors might be involved in sCD14 expression, particularly in atopics, we found no correlation between sCD14 and total IgE concentrations. The usefulness of sCD14 as a marker of atopic disorders should be investigated further, particularly in relation to the severity of allergic disorders.KEY WORDS: allergy; atopy; environmental tobacco smoke; immunoglobulin E; sCD14; pets Prester Lj, et al. Soluble CD14 and total IgE in the serum of atopic and non-atopic adolescents in relation to environmental factors: a pilot study Arh Hig Rada Toksikol 2015;66:41-49

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Increasing trend in atopy markers prevalence in a Croatian adult population between 1985 and 1999

Cited by 14 publications

References 29 publications

Adiposity, serum lipid levels, and allergic sensitization in Chinese men and women

Adiposity, serum lipid levels, and allergic sensitization in Chinese men and women

Is Atopy Related to Neuroticism, Stress, and Subjective Quality of Life?

Soluble CD14 and total IgE in the serum of atopic and nonatopic adolescents in relation to environmental factors: a pilot study / Topivi receptor CD14 i ukupni IgE u serumu mladih atopičara odrasle dobi u ovisnosti o čimbenicima iz okoliša: pilot istraživanje

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