Incremental Prognostic Values of Serum Tenascin-C Levels With Blood B-type Natriuretic Peptide Testing at Discharge in Patients With Dilated Cardiomyopathy and Decompensated Heart Failure

Fujimoto, Naoki; Onishi, Katsuya; Sato, Akira; Terasaki, Fumio; Tsukada, Bin; Nozato, Toshihiro; Yamada, Tomomi; Imanaka‐Yoshida, Kyoko; Yoshida, Toshimichi; M, Ito; Hiroe, Michiaki

doi:10.1016/j.cardfail.2009.06.443

Cited by 49 publications

(38 citation statements)

References 32 publications

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“…Previously, serum TNC level was reported to be related to disease progression and to have prognostic significance in DCM. Serum measurement of TNC level, because of its less invasive nature, could serve as a potential clinical biomarker reflecting TNC expression 19, 20, 22. In the present study, by directly staining myocardial biopsy specimens, we demonstrated that high TNC expression was related to a worse outcome and lower occurrence of reverse remodelling in patients with DCM.…”

Section: Discussionsupporting

confidence: 54%

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Significance of myocardial tenascin‐C expression in left ventricular remodelling and long‐term outcome in patients with dilated cardiomyopathy

Yokokawa

Sugano

Nakayama

et al. 2016

European J of Heart Fail

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AimDilated cardiomyopathy (DCM) has a variety of causes, and no useful approach to predict left ventricular (LV) remodelling and long‐term outcome has yet been established. Myocardial tenascin‐C (TNC) is known to appear under pathological conditions, possibly to regulate cardiac remodelling. The aim of this study was to clarify the significance of myocardial TNC expression in LV remodelling and the long‐term outcome in DCM.Methods and resultsOne hundred and twenty‐three consecutive DCM patients who underwent endomyocardial biopsy for initial diagnosis were studied. Expression of TNC in biopsy sections was analysed immunohistochemically to quantify the ratio of the TNC‐positive area to the whole myocardial tissue area (TNC area). Clinical parameters associated with TNC area were investigated. The patients were divided into two groups based on receiver operating characteristic analysis of TNC area to predict death: high TNC group with TNC area ≥2.3% (22 patients) and low TNC group with TNC area <2.3% (101 patients). High TNC was associated with diabetes mellitus. Comparing echocardiographic findings between before and 9 months after endomyocardial biopsy, the low TNC group was associated with decreased LV end‐diastolic diameter and increased LV ejection fraction, whereas the high TNC group was not. Survival analysis revealed a worse outcome in the high TNC group than in the low TNC group (P < 0.001). Multivariable Cox regression analysis revealed that TNC area was independently associated with poor outcome (HR = 1.347, P = 0.032).ConclusionsIncreased myocardial TNC expression was associated with worse LV remodeling and long‐term outcome in DCM.

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Section: Discussionsupporting

confidence: 54%

“…Recently, several studies have shown that TNC, one of the extracellular matrix component proteins, is expressed in association with several cardiovascular diseases 19, 20. This large glycoprotein (>300 kDa) is expressed only during the development of the embryonic heart and not in the normal adult heart 21.…”

Section: Discussionmentioning

confidence: 99%

Significance of myocardial tenascin‐C expression in left ventricular remodelling and long‐term outcome in patients with dilated cardiomyopathy

Yokokawa

Sugano

Nakayama

et al. 2016

European J of Heart Fail

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show abstract

“…32 In particular, tenascin-C in combination with B-type natriuretic peptide estimation in patients serum, has an incremental prognostic value in patients with DCM and decompensated heart failure. 33 A great and hitherto unsolved clinical problem in DCM patients is the lack of sufficient prognosis predicting markers. Typically, patients with DCM initially present for the first time with dyspnoea and other heart failure symptoms.…”

Section: Tenascin-c In Dilated Cardiomyopathymentioning

confidence: 99%

Tenascin-C in cardiovascular remodeling: potential impact for diagnosis, prognosis estimation and targeted therapy

Franz¹,

Jung

Lauten³

et al. 2015

Cell Adhesion & Migration

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“…60 Likewise, elevated serum TN-C could be a marker for LV remodeling and a predictor of cardiac events in heart failure in patients with DCM, which is comparable to plasma B-type natriuretic peptide (BNP). 61, 62 Particularly interesting is that combining the serum TN-C level with the plasma BNP level is a stronger predictor than either single biomarker alone in 62 The combination of BNP secreted from cardiomyocytes and TN-C synthesized in interstitial fibroblasts could enable more precise assessment of the whole heart by reflecting both cardiomyocytes and interstitial cells.…”

Section: Clinical Applicationmentioning

confidence: 99%

Tenascin-C in Cardiovascular Tissue Remodeling

Imanaka‐Yoshida

2012

Circ J

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Incremental Prognostic Values of Serum Tenascin-C Levels With Blood B-type Natriuretic Peptide Testing at Discharge in Patients With Dilated Cardiomyopathy and Decompensated Heart Failure

Cited by 49 publications

References 32 publications

Significance of myocardial tenascin‐C expression in left ventricular remodelling and long‐term outcome in patients with dilated cardiomyopathy

Significance of myocardial tenascin‐C expression in left ventricular remodelling and long‐term outcome in patients with dilated cardiomyopathy

Tenascin-C in cardiovascular remodeling: potential impact for diagnosis, prognosis estimation and targeted therapy

Tenascin-C in Cardiovascular Tissue Remodeling

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