Incretin-based therapy for glycemic control of hospitalized patients with type 2 diabetes: a systematic review

Gracia-Ramos, Abraham Edgar; Cruz-Domínguez, María Pilar; Madrigal-Santillán, Eduardo

doi:10.1016/j.rceng.2021.09.003

Cited by 2 publications

(1 citation statement)

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“…In Alzheimer's disease patients, there was an inverse correlation between CSF ptau and t-tau and plasma KYN and PA. Furthermore, in the CSF of Alzheimer's disease patients, elevated 3-HK/KYN ratios correlated with t-tau [31]. Moreover, the CSF of Alzheimer's disease patients exhibited noticeably greater concentrations of the L-TRP catabolites QA and KYNA.…”

Section: Kynurenine Pathway Dysfunction In Alzheimer's Disease (Ad)mentioning

confidence: 91%

The Influence of Kynurenine Metabolites on Neurodegenerative Pathologies

Pathak,

Nadar,

Kim

et al. 2024

IJMS

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As the kynurenine pathway’s links to inflammation, the immune system, and neurological disorders became more apparent, it attracted more and more attention. It is the main pathway through which the liver breaks down Tryptophan and the initial step in the creation of nicotinamide adenine dinucleotide (NAD+) in mammals. Immune system activation and the buildup of potentially neurotoxic substances can result from the dysregulation or overactivation of this pathway. Therefore, it is not shocking that kynurenines have been linked to neurological conditions (Depression, Parkinson’s, Alzheimer’s, Huntington’s Disease, Schizophrenia, and cognitive deficits) in relation to inflammation. Nevertheless, preclinical research has demonstrated that kynurenines are essential components of the behavioral analogs of depression and schizophrenia-like cognitive deficits in addition to mediators associated with neurological pathologies due to their neuromodulatory qualities. Neurodegenerative diseases have been extensively associated with neuroactive metabolites of the kynurenine pathway (KP) of tryptophan breakdown. In addition to being a necessary amino acid for protein synthesis, Tryptophan is also transformed into the important neurotransmitters tryptamine and serotonin in higher eukaryotes. In this article, a summary of the KP, its function in neurodegeneration, and the approaches being used currently to target the route therapeutically are discussed.

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Section: Kynurenine Pathway Dysfunction In Alzheimer's Disease (Ad)mentioning

confidence: 91%