“…Moreover, segmentation is one of the central stages for computer aided diagnosis of melanoma with dermoscopic images [13]. The automatic segmentation of skin lesion is particularly challenging because of the possible presence of undesirable factors in the form of skin hairs, specular 2 Mathematical Problems in Engineering reflections, variegated coloring, weak edges, low contrast, irregular and fuzzy borders, marker ink, color chart, ruler marks, dark corners, skin lines, blood vessels, and air or oil bubbles [10,[14][15][16].…”