Indications for Repeat Surgery of Glioblastoma: Influence of Progress of Disease

Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection

“…However, most available studies are of retrospective design and assess only relatively small cohorts of patients. 10,13,16,17,20,26 When comparing repeat surgery with nonsurgical therapy from retrospective and prospective data, studies so far have failed to reveal a benefit from repeat resection. 11,18,27 Recently, a scale was suggested to select patients with recurrent/progressive glioblastomas for repeat resection.…”

The impact of repeated surgery and adjuvant therapy on survival for patients with recurrent glioblastoma

“…In a randomized study comparing the efficacy of implantable Carmustine wafers during reoperation for tumor relapse, Brem et al reported an increase of 6-month survival from 36% (placebo group) to 56% (Carmustine wafers group) [15]. Mortality rate for reintervention is 0-11% [9], surgical morbidity is 13-69% [1,11,16,17]. Age and KPS have been described to be associated with survival, as for newly diagnosed GBM [1].…”