Indicators for secondary carcinoma in head and neck cancer patients following curative therapy: A retrospective clinical study

Abstract

Patients with head and neck squamous cell carcinoma (HNSCC) are at risk for local and regional relapse, as well as for occurrence of synchronous or metachronous secondary carcinoma. The aim of this retrospective study was to evaluate the frequency of secondary malignancies amongst HNSCC patients and their association with age, sex and TNM classification, as well as smoking and alcohol abuse. Data from 394 patients with HNSCC who were treated at the Department of Otorhinolaryngology-Head and Neck Surgery of the University Hospital Mannheim between 2011 and 2015 were retrieved and analyzed using t-tests and P≤0.05 was considered statistically significant. Of the 394 patients, 50 (12.7%) developed a secondary carcinoma. In this cohort, >70% of secondary malignancies were diagnosed using clinical inspection or microlaryngoscopy. The majority of secondary malignancies were identified in the oropharynx, with men being more often affected overall. Continued abuse of carcinogenic substances appeared to increase the incidence of secondary carcinoma, whereas the localization of the primary tumor, age, sex or TNM classification were not identified as significant indicators of the occurrence of a secondary carcinoma. The purpose of the present study was to emphasize the importance of intensive follow-up to ensure early detection of secondary malignancies. The aim was to help predict numbers and occurrence within smaller cohorts, and to evaluate the quality of data collected during the establishment of a certified tumor center. To fully evaluate the role of continued exposure to noxious substances and other possible contributing factors, and in order to improve the rate of early diagnosis and establish preventive strategies, multicentered studies with larger cohorts are required.

Multiple primary squamous cell carcinomas of the oral cavity: A cross-sectional study in vietnam

“…Leon (2009) demonstrated that continuing to smoke and drink alcohol after treatment increased the risk of developing a second malignancy by approximately three to five times, not only for oral cavity tumors but also for tumors affecting the entire upper gastrointestinal tract [ 9 ]. As a result, it is recommended that long-term follow-up of patients with oral cavity cancer who have undergone radical treatment and have abstained from alcohol and tobacco completely can improve survival [ 10 ].…”

Developing a Stacked Ensemble-Based Classification Scheme to Predict Second Primary Cancers in Head and Neck Cancer Survivors

“…Our study revealed that late clinical nodal stage, larger lymph node sizes, lymph node metastasis to level I–III, late combined stage, and late pathologic T stage all contributed to SPC occurrence in HNC survivors. Kuhlin B et al demonstrated that primary tumor localization, age, sex, or TNM classification were not identified as significant indicators of the secondary carcinoma occurrence in 394 cases [ 41 ].…”

Patterns of second primary malignancies in carcinoma larynx and hypopharynx following surgical management

“…[14][15][16] In another large trial by Ping et al with 1512 patients of head and neck carcinoma treated with curative radiotherapy and Kuhln et al following curative treatment the reported incidence of SPM was 9% and 10.3% respectively. 17,18 Our study has taken only surgical candidates of malignancy hypopharynx and larynx following curative treatment and the incidence of SPM was 3.1%. All the candidates were of advanced stage (stage III and IV) requiring multimodality treatment.…”