Indices calculated by serum creatinine and cystatin C as predictors of liver damage, muscle strength and sarcopenia in liver disease

Abstract

Serum creatinine (Cr)-based glomerular filtration rate (CrGFR) is overestimated in liver disease. The present study evaluated whether the difference in CrGFR and cystatin C (CysC) GFR (dGFR) is significant in liver disease. The Cr-to-CysC ratio and sarcopenia index (SI) have been reported to correlate with muscle volume. An estimated total body muscle mass with Cr, CysC and calculated body muscle mass (CBMM) has also been reported to correlate with muscle mass. The applicability of dGFR, SI and CBMM for liver disease were evaluated. A total of 313 patients with liver damage were evaluated for Child-Pugh score, albumin-bilirubin (ALBI) score, model for end-stage liver disease, fibrosis-4, Cr, CysC, Cr-based estimated GFR (CreGFR), CysCGFR and grip strength. Of the 313 patients, 199 were evaluated using cross-sectional computed tomography (CT) of the third lumbar vertebra to determine the skeletal muscle (SM) mass. dGFR, CBMM and SI were compared to liver damage, muscle strength and muscle mass. In the 313 patients, dGFR was correlated with age, ALBI and grip strength; CBMM was correlated with body mass index (BMI) and grip strength; and SI was correlated with BMI and grip strength. In patients evaluated with CT, the correlation coefficients for CBMM and SI with SM were 0.804 and 0.293, respectively. Thus, CBMM and SI were associated with sarcopenia. The relationship between dGFR and ALBI does not differ with different grades of CrGFR-based chronic kidney disease (CKD). dGFR is a marker of liver damage and muscle strength regardless of CKD. CBMM and SI are markers for sarcopenia in liver disease.

Relationships between cystatin C- and creatinine-based eGFR in Japanese rural community- dwelling older adults with sarcopenia

“…This result indicates that even in the participants without end-stage renal failure, only “eGFRcre is more than eGFRcys” may be related to sarcopenia. Recently it has been reported that difference between eGFRcre and eGFRcys (dGFR) correlates with muscle strength positively in patients with liver damage [ 24 ]. The eGFRcre may become detached from eGFRcys in patients with sarcopenia.…”

Comparison of calculated body muscle mass and SARC‑F as methods of screening for sarcopenia in patients with chronic liver disease

“…Chronic kidney disease (CKD) was staged based on the levels of Cr-based eGFRs in ml/min/1.73 m 2 ( 18 ). The difference in GFR was calculated as follows ( 19 ): Cr-based eGFR - CysC-based eGFR. The sarcopenia index was calculated as follows ( 20 ): Cr/CysC x 100.…”

“…Chronic kidney disease (CKD) was staged based on the levels of Cr-based eGFRs in ml/min/1.73 m 2 (18). The difference in GFR was calculated as follows (19) (9). The cutoff SARC-F score for sarcopenia was ≥4 points (6).…”

Direct-acting Antivirals Improved the Quality of Life, Ameliorated Disease-related Symptoms, and Augmented Muscle Volume Three Years Later in Patients with Hepatitis C Virus

“…In addition, a new body muscle mass [calculated body muscle mass (CBMM)] equation to estimate the total body muscle mass using Cr and CysC levels was developed ( 17 ). The difference in the Cr-based estimated glomerular filtration rate (GFR) and the CysC GFR (dGFR) has been reported as a marker of liver damage and muscle strength ( 18 ). We therefore compared PROs and the SI/CBMM/dGFR to evaluate the association between the QOL and muscle mass.…”