Objective To perform a quantitative analysis of the brain volume of elderly
individuals in a population-based sample. Materials and Methods This was a radiological assessment and voxel-based quantitative analysis,
with surface alignment, of 525 magnetic resonance imaging scans of
individuals between 60 and 103 years of age who participated in the
Saúde, Bem-estar e Envelhecimento (Health,
Well-being, and Aging) study in the city of São Paulo, Brazil.Results We noted a median rate of reduction in total brain volume of 2.4% per decade
after 60 years of age. Gray and white matter both showed volume reductions
with age. The total brain volume/intracranial brain volume ratio differed
between males and females. Conclusion We have corroborated the findings of studies conducted in the United States
and Europe. The total brain volume/intracranial brain volume ratio is higher
in men, representing a potential bias for the conventional radiological
assessment of atrophy, which is typically based on the evaluation of the
cerebrospinal fluid spaces.