Indion 860 catalyzed cascade reaction: a greener approach to functionalized cyclohexanones and their novel analogues

An Approach to the Diastereoselective Synthesis of Cyclohexane-1,3-dicarboxamide Derivatives via a Pseudo Five-Component ­Reaction Based on Diketene

“…These cyclohexanones can serve as synthons in further synthetic endeavors, as they possess β-keto amide and βhydroxy ketone moieties. 20 The chemical properties of 4hydroxy-6-oxo-cyclohexane-1,3-dicarboxamides have been previously investigated. Their reactions with p-toluidine, hydrazine hydrate, and cyanoacetic acid hydrazide resulted in the formation of the dehydration product and tetrahydroindazole.…”

Synthesis of Pyridine-Dicarboxamide-Cyclohexanone Derivatives: Anticancer and α-Glucosidase Inhibitory Activities and In Silico Study

“…These molecules possess antibacterial [13], anticonvulsant [14], antifungal and anticancer [15] properties. In general, cyclohexanone is a common scaffold in various bioactive heterocycles of medicinal interests, particularly those used for the treatment of asthma and central nervous system (CNS)- and chronic obstructive pulmonary diseases (COPD)-related diseases, due to its inhibitory activity against phosphodiesterase 4 (PDE4) [16,17].…”

Facile One-Pot Method for the Synthesis of Polysubstituted Phthalide Derivatives

“…Recently, methods that construct the aromatic backbone from acyclic precursors have received growing interest because of their short synthetic steps. [13][14][15][16][17] Herein, we describe an efficient method to synthesize polysubstituted phthalides from ethyl 4-chloroacetoacetate and aldehydes in the presence of piperidine, acid, and iodine (Scheme 2). Our method is simple and economical because no special apparatus or chemical is required.…”