Indiosides G–K: Steroidal Glycosides with Cytotoxic and Anti-inflammatory Activities from <i>Solanum violaceum</i>

Yen, Chiao Ting; Lee, Chia-Lin; Chang, Fang Rong; Hwang, Tsong‐Long; Yen, Hsin Fu; Chen, Chao‐Jung; Chen, Shu Li; Wu, Yang Chang

doi:10.1021/np200877u

Cited by 18 publications

(14 citation statements)

References 25 publications

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“…Indiosides G ( 82 ) and H ( 83 ) with an iso-type F ring were isolated from the methanolic extract of the whole plant of S. violaceum , together with indioside I ( 86 ), and two unusual furostanol saponins with a deformed F ring, indiosides J ( 87 ) and K ( 88 ) [391, 392]. In addition, four steroidal sapogenins, indiosides L–O ( 78 – 81 ) were also obtained from this plant [391].…”

Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

“…Indioside H ( 83 ), borassoside E ( 85 ), indioside I ( 86 ) and yamoscin ( 89 ) demonstrated cytotoxic activity against six human cancer cell lines (HepG2, Hep3B, A549, Ca9-22, MDA-MB-231, and MCF-7) (IC 50 = 1.83–8.04 μg/mL) [392]. Seperately, 85 and 86 presented inflammation inhibitory effects on SAG (IC 50 = 0.62 ± 0.03 and 2.84 ± 0.18 μg/mL, resp.).…”

Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

“…Seperately, 85 and 86 presented inflammation inhibitory effects on SAG (IC 50 = 0.62 ± 0.03 and 2.84 ± 0.18 μg/mL, resp.). Compound 85 also inhibited elastase release with IC 50 values of 111.05 ± 7.37 μg/mL [392], while 89 showed anti-neutrophilic inflammatory activity against SAG with an IC 50 value of 3.59 μM [331]. …”

Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

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The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Kaunda

Zhang

2019

Nat. Prod. Bioprospect.

111

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Over the past 30 years, the genus Solanum has received considerable attention in chemical and biological studies. Solanum is the largest genus in the family Solanaceae, comprising of about 2000 species distributed in the subtropical and tropical regions of Africa, Australia, and parts of Asia, e.g., China, India and Japan. Many of them are economically significant species. Previous phytochemical investigations on Solanum species led to the identification of steroidal saponins, steroidal alkaloids, terpenes, flavonoids, lignans, sterols, phenolic comopunds, coumarins, amongst other compounds. Many species belonging to this genus present huge range of pharmacological activities such as cytotoxicity to different tumors as breast cancer (4T1 and EMT), colorectal cancer (HCT116, HT29, and SW480), and prostate cancer (DU145) cell lines. The biological activities have been attributed to a number of steroidal saponins, steroidal alkaloids and phenols. This review features 65 phytochemically studied species of Solanum between 1990 and 2018, fetched from SciFinder, Pubmed, ScienceDirect, Wikipedia and Baidu, using “Solanum” and the species’ names as search terms (“all fields”).

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Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

See 1 more Smart Citation

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Kaunda

Zhang

2019

Nat. Prod. Bioprospect.

111

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“…Anticarcinogenic activity was shown by a variety of steroidal saponins from different plants including Digitalis trojana (Kirmizibekmez et al 2014), Allium schoenoprasum (Timité et al 2013), Dioscorea zingiberensis (Tong et al 2012), Fagonia indica (Waheed et al 2012), Rhizoma Paridis (Xiao et al 2012), Solanum violaceum (Yen et al 2012), Agave sisalana (Chen et al 2011a, b), Anemarrhena asphodeloides (Kang et al 2011), Dioscorea bulbifera , Trigonella foenum-graecum (Kawabata et al 2011), Paris polyphylla (Zhu et al 2011), Raphia farinifera (Tapondjou et al 2015) etc.…”

Section: The Value Of Steroidal Saponinsmentioning

confidence: 99%

Recent advances in steroidal saponins biosynthesis and in vitro production

Upadhyay

Jeena

Shikha

et al. 2018

Planta

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Main conclusion Steroidal saponins exhibited numerous pharmacological activities due to the modification of their backbone by different cytochrome P450s (P450) and UDP glycosyltransferases (UGTs). Plant-derived steroidal saponins are not sufficient for utilizing them for commercial purpose so in vitro production of saponin by tissue culture, root culture, embryo culture, etc, is necessary for its large-scale production.Saponin glycosides are the important class of plant secondary metabolites, which consists of either steroidal or terpenoidal backbone. Due to the existence of a wide range of medicinal properties, saponin glycosides are pharmacologically very important. This review is focused on important medicinal properties of steroidal saponin, its occurrence, and biosynthesis. In addition to this, some recently identified plants containing steroidal saponins in different parts were summarized. The high throughput transcriptome sequencing approach elaborates our understanding related to the secondary metabolic pathway and its regulation even in the absence of adequate genomic information of non-model plants. The aim of this review is to encapsulate the information related to applications of steroidal saponin and its biosynthetic enzymes specially P450s and UGTs that are involved at later stage modifications of saponin backbone. Lastly, we discussed the in vitro production of steroidal saponin as the plant-based production of saponin is time-consuming and yield a limited amount of saponins. A large amount of plant material has been used to increase the production of steroidal saponin by employing in vitro culture technique, which has received a lot of attention in past two decades and provides a way to conserve medicinal plants as well as to escape them for being endangered.

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“…Furthermore, antihelmentic and antimicrobial activities were also demonstrated along with the presence of alkaloid, carbohydrate, flavonoids, phenols, glycoside, saponin, gums, diterpenes, proteins and tannins as phytoconstituents (Raju et al 2013). It is also evident to have antioxidant (Tzekuei and Tsuiching 2009), cytotoxic and anti-inflammatory activities (Yen et al 2012). Inflammation involves the biosynthesis of prostaglandin (PG), plays a key role to produce pain and pyrexia.…”

Section: Introductionmentioning

confidence: 99%

Anti-nociceptive and antipyretic activities of Solanum violaceum ortega

Karim

Islam

Tareq

et al. 2017

IJM

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Solanum violaceum Ortega has been used by the traditional medicine practitioners in pain and fever. This study aimed at investigating anti-nociceptive and antipyretic activities of methanol extract of leaf (MELSV), fruit (MEFSV) and root (MERSV) of S. violaceum in Swiss albino mice. Anti-nociceptive activity was evaluated using hot plate method while antipyretic by brewer's yeast induced hyperpyrexia. In both tests, test animals were divided into eight groups of six in each. The groups were treated as negative control (distilled water), standard and tests (250 and 500 mg/kg of MELSV/ MERSV/ MERSV). Diclofenac sodium (150 mg/kg) and paracetamol (150 mg/kg) were taken as standards for anti-nociceptive and antipyretic tests, respectively. All the treatments were administrated via oral gavages (p.o.). Results suggest that, the plant extracts dose-dependently increased retention time compared to the control groups. MELSV at 500 mg/kg significantly increased retention time on the hot-pate of the test animals than the MEFSV and MERSV treated groups. In the antipyretic test, both 250 and 500 mg/kg of MELSV and 500 mg/kg of MEFSV significantly (p <0.05) decreased temperature to the experimental animals 30, 60, 120 minutes. In conclusion, the crude extracts of S. violaceum exhibited anti-nociceptive and antipyretic activities. S. violaceum may be one of the good sources of anti-nociceptive and antipyretic compounds.

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Indiosides G–K: Steroidal Glycosides with Cytotoxic and Anti-inflammatory Activities from Solanum violaceum

Cited by 18 publications

References 25 publications

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Recent advances in steroidal saponins biosynthesis and in vitro production

Anti-nociceptive and antipyretic activities of Solanum violaceum ortega

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