Indirect atomic absorption spectrometric determination of pindolol, propranolol and levamisole hydrochlorides based on formation of ion associates with manganese thiocyanate and potassium ferricyanide

Khalil, Sabry; Elrabiehi, M.M.

doi:10.1016/s0731-7085(99)00240-x

Cited by 24 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…polishing or modification with RGO) or pre-treatment, and hence we question the need to use RGO in the first place. In comparison of our work against prior analytical (non-electrochemical technologies), the analytical performance of our electroanalytical protocol can be considered superior to that previously reported research [45][46][47][48][49] because of the inessential pre-treatment and modification of the surface whilst also being cheap and disposable sensors.…”

Section: Discussionmentioning

confidence: 72%

Electroanalytical detection of pindolol: comparison of unmodified and reduced graphene oxide modified screen-printed graphite electrodes

Cumba

Smith

Brownson

et al. 2015

Analyst

View full text Add to dashboard Cite

Recent work has reported the first electroanalytical detection of pindolol using reduced graphene oxide (RGO) modified glassy carbon electrodes [S. Smarzewska and W. Ciesielski, Anal. Methods, 2014, 6, 5038] where it was reported that the use of RGO provided significant improvements in the electroanalytical signal in comparison to a bare (unmodified) glassy carbon electrode. We demonstrate, for the first time, that the electroanalytical quantification of pindolol is actually possible using bare (unmodified) screen-printed graphite electrodes (SPEs). This paper addresses the electroanalytical determination of pindolol utilising RGO modified SPEs. Surprisingly, it is found that bare (unmodified) SPEs provide superior electrochemical signatures over that of RGO modified SPEs. Consequently the electroanalytical sensing of pindolol is explored at bare unmodified SPEs where a linear range between 0.1 μM-10.0 μM is found to be possible whilst offering a limit of detection (3σ) corresponding to 0.097 μM. This provides a convenient yet analytically sensitive method for sensing pindolol. The optimised electroanalytical protocol using the unmodified SPEs, which requires no pre-treatment (electrode polishing) or electrode modification step (such as with the use of RGO), was then further applied to the determination of pindolol in urine samples. This work demonstrates that the use of RGO modified SPEs have no significant benefits when compared to the bare (unmodified) alternative and that the RGO free electrode surface can provide electro-analytically useful performances.

show abstract

Section: Discussionmentioning

confidence: 72%

Electroanalytical detection of pindolol: comparison of unmodified and reduced graphene oxide modified screen-printed graphite electrodes

Cumba

Smith

Brownson

et al. 2015

Analyst

View full text Add to dashboard Cite

show abstract

“…(5 mg mL À1 ), 15 (15 ng mL À1 ), 19 longer linear ranges (1.0 Â 10 À7 -1.0 Â 10 À5 mol L À1 ), in comparison to i.e. (0.04-1.2 mg mL À1 ), 3 (5-120 mg mL À1 ) 13 (1.14-17.07 mg mL À1 ), 17,18 (5-150 ng mL À1 ), 23 (2.5-30 ng mL À1 ) 24 and guarantee simpler sample preparation than all previously known spectroscopic and chromatographic methods [12][13][14][15][16][17][18][19][20][21][22][23][24] for quantitative PND determination.…”

Section: Discussionmentioning

confidence: 97%

Electroanalysis of pindolol on a GCE modified with reduced graphene oxide

Smarzewska

Ciesielski

2014

Anal. Methods

View full text Add to dashboard Cite

In this work, the application of an innovative, environmentally friendly reduced graphene oxide-glassy carbon (RGO-GC) electrode is described. Using the RGO-GC electrode, basic electrochemical properties (such as the number of protons and electrons involved in an oxidation process, heterogeneous rate constant, diffusion coefficient and electron transfer coefficient) of pindolol (PND) were studied. It was observed that the indole moiety is a part of the pindolol molecule where oxidation takes place. Additionally, a square-wave stripping voltammetric method for the quantitative determination of PND was developed. The influence of various factors such as pH, buffer concentration and SWSV (square wave stripping voltammetry) parameters were studied. The best results in terms of signal shape and intensity were recorded in a BR buffer at pH 5.0. This electroanalytical procedure was used to determine pindolol on the RGO-GC electrode in a concentration range of 1 Â 10 À7 to 1 Â 10 À5 mol L À1. The precision, repeatability and accuracy of the method were checked. The detection and quantification limits were found to be 2.6 Â 10 À8 and 8.6 Â 10 À8 mol L À1 , respectively. The method has been satisfactorily applied to the determination of pindolol in urine samples and pharmaceutical formulations.

show abstract

“…Therefore the development of an analytical method for the determination of metoprolol tartrate is of great significance. The assay procedures of this drug listed in USP 23 NF18 (1995) [2] and BP (1998) [3] describe titrimetric and spectrophotometric methods [4,5]. In addition, several methods have been reported for quantification of MPT in plasma using high-performance liquid chromatography (HPLC) with UV or fluorescence detection [6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Metoprolol Tartrate in Pharmaceutical Dosage Forms on Complex Formation with Cu(II)

Çeşme¹,

Tarınç²,

Gölcü³

2012

CHEMISTRY

View full text Add to dashboard Cite

Abstract:A new, simple, sensitive and accurate spectrophotometric method has been developed for the assay of metoprolol tartrate (MPT), which is based on the complexation of drug with copper(II) [Cu(II)] at pH 6.0, using Britton-Robinson buffer solution, to produce a blue adduct. The latter has a maximum absorbance at 675 nm and obeys Beer's law within the concentration range 8.5-70 µg/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.998) with a limit of detection of 5.56 µg/mL. The proposed procedure has been successfully applied to the determination of this drug in its tablets. In addition, the spectral data and stability constant for the binuclear copper(II) complex of MPT (Cu 2 MPT 2 Cl 2 ) have been reported.

show abstract

Indirect atomic absorption spectrometric determination of pindolol, propranolol and levamisole hydrochlorides based on formation of ion associates with manganese thiocyanate and potassium ferricyanide

Cited by 24 publications

References 22 publications

Electroanalytical detection of pindolol: comparison of unmodified and reduced graphene oxide modified screen-printed graphite electrodes

Electroanalytical detection of pindolol: comparison of unmodified and reduced graphene oxide modified screen-printed graphite electrodes

Electroanalysis of pindolol on a GCE modified with reduced graphene oxide

Spectrophotometric Determination of Metoprolol Tartrate in Pharmaceutical Dosage Forms on Complex Formation with Cu(II)

Contact Info

Product

Resources

About