Individual and Combined Diagnostic Accuracy of Biochemical Markers for Detecting Early On-Set Preeclampsia

Abstract

Background: Preeclampsia (PE) is one of the leading causes of maternal and neonatal mortality across the globe. Existing diagnostic parameters of PE have not proven to be sufficient in detecting the condition in its early stage. It is imperative to evaluate the biomarkers that are involve in the pathogenesis of PE, to identify which of them is specific and sensitive enough to detect early onset PE to prevent its associated adverse outcomes. This study evaluated the individual and combine diagnostic accuracy of angiogenic factors oxidative stress biomarkers, spot urine protein, creatinine and uric acid for detecting early onset PE.

Longitudinal 8-Epi-Prostaglandin F2-Alpha and Angiogenic Profile Mediator Evaluation during Pregnancy in Women with Suspected or Confirmed Pre-eclampsia

“…Studies published by Turpin et al, Sakyi et al, and Anto et al [38][39][40]42] evaluated the association of oxidative stress biomarkers (8-epi-PGF2α, 8-OHdG, and total antioxidant capacity) and angiogenic growth mediators (sFlt-1, PlGF, sEng, vascular endothelial growth factor-A, VEGF-A) in early-onset pre-eclampsia (EO-PE) and late-onset preeclampsia (LO-PE) at the time of diagnosis and 48 h post-partum. Turpin et al [38] and Alahakoon et al [11] discovered that EO-PE women had significantly higher angiogenic imbalance and OS than LO-PE women, implying that EO-PE pregnancies are frequently more severe and have worse maternal outcomes than LO-PE pregnancies.…”

“…For the first time, Sakyi et al [39] determined that, in the Ghanaian population, the ratios of 8-epiPGF2α/PlGF and PIGF/8-epiPGF2α were significant diagnostic markers for EO-PE (<34 weeks), with a threshold of 7.2 and above for the former and 0.14 and lower for the latter. PE women were 1.74 times more likely to have EO-PE at this threshold value.…”

“…Our preliminary study showed that the expression levels of serum 8-iso-PGF2α in the PE group were higher than that in the PE after-delivery group. Previous studies have evaluated 8-epi-PGF2α and 8-hydroxy-2-deoxyguanosine (8-OHdG) at the time of diagnosis and post-partum [38][39][40][41][42].…”