Individual differences in GHB consumption in a new voluntary GHB self-administration model in outbred rats
Casper J. H. Wolf,
Marcia Spoelder,
Harmen Beurmanjer
et al.
Abstract:Background and purpose
The use of the recreational drug gamma-hydroxybutyric acid (GHB) has increased over the past decade, concomitantly leading to a higher incidence of GHB use disorder. Evidence-based treatment interventions are hardly available and cognitive effects of long-term GHB use remain elusive. In order to study the development of GUD and the causal effects of chronic GHB consumption, a GHB self-administration model is required.
Experimental approach
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