Individual differences in sexual responsiveness to estrogen and progesterone in ovariectomized rats

Powers, J.Bradley; Valenstein, Elliot S.

doi:10.1016/0031-9384(72)90093-5

Cited by 55 publications

(20 citation statements)

References 23 publications

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“…This concurs with physiological evidence wherein male rats showed an augmented Fos response in the MPOA following copulation with an estrous female rat (Baum & Everitt, ). In contrast to males, MPOA lesions facilitated the display of sexual behavior in adult female rats (Hoshina, Takeo, Nakano, Sato, & Sakuma, ; Powers & Valenstein, ). Interestingly, MPOA lesions also disrupt the onset and the maintenance of maternal behavior (Numan, ; Numan, Rosenblatt, & Komisaruk, ), suggesting that activation of the MPOA inhibits pathways mediating female sexual behaviors, but activates pathways mediating maternal behaviors.…”

Section: Discussionmentioning

confidence: 99%

Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network

DiBenedictis

Nussbaum

Cheung

et al. 2017

J of Comparative Neurology

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The neuropeptides vasopressin (AVP) and oxytocin (OT) have been implicated in the regulation of numerous social behaviors in adult and juvenile animals. AVP and OT signaling predominantly occur within a circuit of interconnected brain regions known collectively as the “social behavior neural network” (SBNN). Importantly, AVP and OT signaling within the SBNN has been shown to differentially regulate diverse social behaviors, depending on the age and/or sex of the animal. We hypothesized that variation in the display of these behaviors is due in part to age and sex differences in AVP and OT synthesis within the SBNN. However, a thorough characterization of AVP and OT-immunoreactive (ir) fibers and cell bodies across age and sex within the SBNN has been lacking in rats. We therefore quantified AVP- and OT-ir fibers and cell bodies in 22 subregions of the fore-brain SBNN in juvenile and adult, male and female rats. We found numerous age (16 subregions) and sex (10 subregions) differences in AVP-ir fiber fractional areas, and AVP-ir cell body numbers, which were mainly observed in the medial amygdala/bed nucleus of the stria terminalis to lateral septum circuit. In contrast to AVP, we observed no age or sex differences in OT-ir fiber fractional areas or cell bodies in any of the 22 subregions of the forebrain SBNN. Thus, unlike the static pattern observed for OT, AVP innervation of the forebrain SBNN appears to undergo developmental changes, and is highly sexually dimorphic, which likely has significant functional consequences for the regulation of social behavior.

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Section: Discussionmentioning

confidence: 99%

Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network

DiBenedictis

Nussbaum

Cheung

et al. 2017

J of Comparative Neurology

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“…These data suggest that this dose of RU-486 is blocking P-induced behavior by interfering with the activation of PRs. The dosage of P was chosen because it yields physiological levels of P that are observed following stress in male rats [30], [31], and is sufficient to induce sexual behavior in female rats [32], [33]. Four hours after the final P injection animals were tested in the elevated plus maze and light/dark chamber during the dark phase of the light cycle under dim red light.…”

Section: Methodsmentioning

confidence: 99%

Progestin Receptor-Mediated Reduction of Anxiety-Like Behavior in Male Rats

Auger

Forbes-Lorman

2008

PLoS ONE

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BackgroundIt is well known progesterone can have anxiolytic-like effects in animals in a number of different behavioral testing paradigms. Although progesterone is known to influence physiology and behavior by binding to classical intracellular progestin receptors, progesterone's anxiety reducing effects have solely been attributed to its rapid non-genomic effects at the GABAA receptor. This modulation occurs following the bioconversion of progesterone to allopregnanolone. Seemingly paradoxical results from some studies suggested that the function of progesterone to reduce anxiety-like behavior may not be entirely clear; therefore, we hypothesized that progesterone might also act upon progestin receptors to regulate anxiety.Methodology/Principal FindingsTo test this, we examined the anxiolytic-like effects of progesterone in male rats using the elevated plus maze, a validated test of anxiety, and the light/dark chamber in the presence or absence of a progestin receptor antagonist, RU 486. Here we present evidence suggesting that the anxiolytic-like effects of progesterone in male rats can be mediated, in part, by progestin receptors, as these effects are blocked by prior treatment with a progestin receptor antagonist.Conclusion/SignificanceThis indicates that progesterone can act upon progestin receptors to regulate anxiety-like behavior in the male rat brain.

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“…For example, circulating concen trations of E during proestrus in rats, guinea pigs, and hamsters are 50, 70 and 190 pg/ml, respectively [29], The species also differ in sensitivity to E. The induction of lor dosis by E treatment requires only 1-2 pg/kg BW in rats [30], 2-5 pg/kg BW in guinea pigs, and 90 pg/kg BW in hamsters [31], These differences in sensitivity to E are paralleled by differences in E-binding capacity in the brain. In a comparative study of neural uptake of tritiated E in the hypothalamus, rat and guinea pig tissue bound 3-5 times the amount of Eas hamster tissue [31].…”

Section: Species Differences In Sensitivity To Steroid Hormonesmentioning

confidence: 99%

Species Differences in Behavioral and Neural Sensitivity to Estrogen in Whiptail Lizards: Correlation with Hormone Receptor Messenger Ribonucleic Acid Expression

1995

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Cnemidophorus uniparens is a unisexual species of whiptail lizard of hybrid origin whereas C. inornatus is a sexual species and the maternal ancestor of C. uniparens. Together they represent an excellent model system for investigating the evolution of hormone-brain-behavior relationships. Normal circulating estradiol (E) concentrations in C. uniparens are approximately 5-fold lower than those of female C. inornatus in a similar reproductive state. Experiments were performed to determine whether (i) C. uniparens is more sensitive to E, and (ii) whether the difference in sensitivity is correlated with differences in estrogen receptor (ER)-mRNA expression in the brain. Dose-response curves reveal that ovariectomized C. uniparens are more responsive than ovariectomized C. inornatus to exogenous estradiol 17β-benzoate (EB). EB is more effective in C. uniparens at inducing receptive behavior and progesterone receptor (PR) gene expression in the ventromedial nucleus of the hypo-thalamus (VMH). In situ hybridization analysis of ER-mRNA expression revealed no species differences in ER-mRNA content in the VMH of ovariectomized animals. Treatment of ovariectomized animals with EB resulted in a greater induction of ER-mRNA expression in the VMH of C. uniparens compared to C. inornatus. These results indicate that the differences in behavioral sensitivity to E lie in the estrogen target neurons in the brain region controlling receptive behavior, the VMH, and that the difference in sensitivity cannot be explained by species differences in the basal rate of ER gene expression.

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Individual differences in sexual responsiveness to estrogen and progesterone in ovariectomized rats

Cited by 55 publications

References 23 publications

Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network

Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network

Progestin Receptor-Mediated Reduction of Anxiety-Like Behavior in Male Rats

Species Differences in Behavioral and Neural Sensitivity to Estrogen in Whiptail Lizards: Correlation with Hormone Receptor Messenger Ribonucleic Acid Expression

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