Individual differences in trait anxiety are associated with white matter tract integrity in fornix and uncinate fasciculus: Preliminary evidence from a DTI based tractography study

Aberrant functional connectivity of resting state networks associated with trait anxiety

“…General Linear Model (GLM) was then defined to create multi-subject design matrix defining groups (two groups: high anxiety (HA) and low anxiety (LA)) and contrast files (two contrasts: LA vs HA and HA vs LA). Since the primary aim of the study was to study the effect of trait anxiety, a personality dimention, on the RSNs and not that of transient intensity of depressive feeling, a new regressor for current depression levels was also added (following some of the earlier studies such as Baur et al, 2012;Modi et al, 2013;Modi et al, 2014). For doing so, BDI score was mean centered (by subtracting the overall mean BDI score from each individual score) and added as a regressor.…”

“…ϯ associated with anxiety related personality traits (Westlye et al, 2011;Montag et al, 2012;Modi et al, 2013). The high anxiety trait is considered to be a vulnerability factor to develop both depression and anxiety disorders (Pezawas et al, 2005;Sandi and Richter-Levin, 2009;Cremers et al, 2010).…”

Neuroanatomical correlates of negative emotionality-related traits: A systematic review and meta-analysis

“…Four studies reported positive correlations between NE-traits and FA values -in the R cingulum with N scores (Madsen et al 2012), in the fornix and left uncinate fasciculus with trait anxiety scores in a relatively small sample (Modi et al, 2013), and in the major WM tracts -IFOF, SLF, SLF temporal, UF, cingulum-hippocampus with the "trait anxiety" factor (obtained through PCA from three personality dimensions -HA, BIS, and N) but only in males (Montag et al, 2012), and in the R amygdala-vPFC with trait anxiety level (Clewett et al, 2015). Another study using probabilistic tractography in healthy volunteers, revealed a direct pathway between basolateral amygdala and anterior insula, in which axial diffusivity (but not fractional anisotropy) correlated positively with the trait anxiety scores (Baur et al, 2013).…”

Development of White Matter Microstructure and Intrinsic Functional Connectivity Between the Amygdala and Ventromedial Prefrontal Cortex: Associations With Anxiety and Depression

“…However, even within a single disorder, results are conflicting, some reporting hypo-connectivity while others find hyper-connectivity(8;40;48;49). Discrepancy in amygdala-vmPFC connectivity findings may be due to differences in age ranges examined (50;51), not addressing developmental effects (52;53), and the specific amygdala and vmPFC subregions examined.…”