Individualization of dosage for oral theophylline therapy

Cabañas, Rodrigo Tovar; Peña, June Bryan dela; Castro-Gago, Manuel; Tojo, Rafael

doi:10.1016/s0022-3476(82)80269-2

The Journal of Pediatrics

1982

DOI: 10.1016/s0022-3476(82)80269-2

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Individualization of dosage for oral theophylline therapy

Rodrigo Tovar Cabañas¹,

June Bryan dela Peña²,

Manuel Castro-Gago³

et al.

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1983

1988

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Cited by 3 publications

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Individualization of Theophylline Dosage in Adults with Bronchial Asthma

Otero¹,

Barrueco²,

Mariño³

et al. 1986

Drug Intelligence & Clinical Pharmacy

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The influence of age on the disposition of theophylline was studied in 95 adult patients (nonsmokers) with bronchial asthma requiring oral theophylline therapy: 17 patients age less than or equal to 39 years, 50 patients age 40-59 years, and 28 patients greater than or equal to 60 years. A decrease was observed in total body clearance together with an increase in the elimination half-life of theophylline parallel to the advance in age of the patients. The apparent volume of distribution of theophylline was similar in the three groups of patients. According to the results obtained, recommendations are made regarding the dosage regimens of theophylline in elderly patients.

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Individualization of Theophylline Dosage in Adults with Bronchial Asthma

Otero¹,

Barrueco²,

Mariño³

et al. 1986

Drug Intelligence & Clinical Pharmacy

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show abstract

Algorithms for Dosage and Therapeutic Monitoring of Theophylline

Mangues

Bonal²,

Farre³

et al. 1988

Drug Intelligence & Clinical Pharmacy

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Theophylline is widely prescribed in Spain. Because this drug has a narrow therapeutic range and high interindividual pharmacokinetic variability, it is essential to adapt the dosage to each patient. In order to simplify the drug individualization we are proposing three algorithms to apply to intravenous loading and maintenance doses and to oral doses. The initial recommended dosages have been established using the pharmacokinetic parameters obtained from patients treated with theophylline in our hospital. Because the pharmacokinetic behavior of theophylline may be different in other populations, dosage requirements may not be the same. A minimum number of blood sample collections is proposed in an attempt to improve the cost-benefit relationship in theophylline therapy.

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Pharmacokinetics of a sustained-release theophylline preparation in healthy subjects.

Goto¹,

Nakamoto²,

Sugiyama³

et al. 1983

Journal of Pharmacobio-Dynamics

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A comparative pharmacokinetic study between a sustained-release theophylline tablet (Theona) and aminophylline powder following multiple oral administrations every 12 h at a 200 mg theophylline dose was performed in ten healthy adult volunteers. As the results, theophylline in Theona revealed almost completely absorbed as is aminophylline. A peak-trough difference with Theona was less than half of that with aminophylline powder. These results suggest that Theona has excellent characteristics as a sustained-release preparation. In addition, in order to investigate dose-dependent kinetics for theophylline, the relationship between average plasma level and dosage was examined with Theona. The plasma level showed proportional change at the low concentrations. When the plasma level was close to 10 micrograms/ml, however, dosage increment results in an increasingly greater change of plasma level, which may indicate a high risk of toxicity.

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Individualization of dosage for oral theophylline therapy

Cited by 3 publications

References 2 publications

Individualization of Theophylline Dosage in Adults with Bronchial Asthma

Individualization of Theophylline Dosage in Adults with Bronchial Asthma

Algorithms for Dosage and Therapeutic Monitoring of Theophylline

Pharmacokinetics of a sustained-release theophylline preparation in healthy subjects.

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